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Gene protects adults abused as children from depression
Some forms of a gene that controls the body's response to stress hormones appear to protect adults who were abused in childhood from depression, psychiatrists have found.   view more (2008-02-05)

Study connects obesity with nervous system
A discovery by Queen's biologists and their students sheds new light on the genetic roots of obesity - a condition that is increasing dramatically in North America and has been linked to heart disease, diabetes and some forms of cancer.   view more (2008-01-24)

Weill Cornell Team Discovers How Brain's Own tPA Helps Regulate Blood Flow to Neurons
The human brain contains its own store of a powerful enzyme (and stroke drug) called tissue plasminogen activator (tPA), which appears to be a key regulator of blood flow to brain cells, a team at the Weill Cornell Medical College in New York City reports.   view more (2008-01-18)

Popular osteoporosis drugs triple risk of bone necrosis
A University of British Columbia and Vancouver Coastal Health Research Institute study has found that a popular class of osteoporosis drugs nearly triples the risk of developing bone necrosis, a condition that can lead to disfigurement and incapacitating pain.   view more (2008-01-16)

Findings Point to Molecular 'Achilles Heel' for Half of Breast Cancer Tumors
Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have shown why a protein known as cyclin D1 may be the Achilles heel for breast tumors that are estrogen receptor positive (ER+) − which is the most common type of breast cancer.   view more (2008-01-16)

Low testosterone levels associated with risk of fracture in men over 60
Men over age 60 who have low blood testosterone levels may be at a higher risk for fractures.   view more (2008-01-15)

Combined HRT increases risk of lobular breast cancer fourfold after just 3 years of use
Postmenopausal women who take combined estrogen/progestin hormone-replacement therapy for three years or more face a fourfold increased risk of developing various forms of lobular breast cancer, according to new findings by researchers at Fred Hutchinson Cancer Research Center.   view more (2008-01-15)

Common molecule notifies immune system of prostate cancer
In experiments with mice, researchers have found that the body's immune system can use a surprisingly common molecule to recognize prostate tumors. The molecule comes from a protein found in all cells of the body; however, immune cells appear to respond to it only when it is present on the surface... view more (2008-01-11)

New treatment mechanisms for schizophrenia
The field of schizophrenia research has come alive with many exciting new potential approaches to treatment. From the introduction of chlorpromazine to the current day, all treatments approved by the U.S. Food and Drug Administration have had, at their core, a single treatment mechanism, the... view more (2008-01-09)

MIT finds key to avian flu in humans
MIT researchers have uncovered a critical difference between flu viruses that infect birds and humans, a discovery that could help scientists monitor the evolution of avian flu strains and aid in the development of vaccines against a deadly flu pandemic.   view more (2008-01-07)

Novel mechanism for long-term learning identified by Carnegie Mellon researchers
Practice makes perfect - or at least that's what we're told as we struggle through endless rounds of multiplication tables, goal kicks and piano scales - and it seems, based on the personal experience of many, to be true.   view more (2008-01-04)

Human hormone blocker found to help prevent obesity and diabetes: study
A new study finds that a chemical found in the body is capable of promoting weight loss, improving insulin resistance and reversing diabetes in an animal model. The hormone is gastric inhibitory polypeptide (GIP) receptor blockade.   view more (2008-01-04)

Some antipsychotic drugs may be missing their mark
Drugs that treat depression, schizophrenia and other psychotic conditions and that target a particular protein on brain cells might not be triggering the most appropriate response in those cells, new research suggests.   view more (2008-01-02)

Gene variation may elevate risk of liver tumor in patients with cirrhosis
A particular gene variation appears to significantly increase the risk that individuals with cirrhosis of the liver will go on to develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause of cancer death.   view more (2008-01-02)

Research suggests new treatment suitable for all patients
New research at Wake Forest University Baptist Medical Center suggests that a three-drug cocktail may one day improve outcomes in patients with glioblastoma multiforme (GBM), a type of brain tumor with a dismal prognosis.   view more (2008-01-02)

Overeating and obesity triggered by lack of BDNF
According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight.   view more (2007-12-28)

Taxol with avastin produces noteworthy results
The positive results of the first nationwide clinical study showing the benefits of an antiangiogenic agent in breast cancer therapy are reported in the Dec. 27 issue of the New England Journal of Medicine.   view more (2007-12-28)

Cell-death receptor links cancer susceptibility and inflammation
For over 10 years, Wafik S. El-Deiry, MD, PhD, Professor of Medicine, Genetics, and Pharmacology at the University of Pennsylvania School of Medicine, has been pursuing a cancer-targeting molecule called TRAIL and its molecular partners.   view more (2007-12-28)

Chemotherapy and tamoxifen reduce risk of second breast cancer
Among breast cancer patients, both chemotherapy and tamoxifen independently reduced the risk of developing a second cancer in the other breast, according to a study published online December 25 in the Journal of the National Cancer Institute. The risk reduction persisted for at least 10 and 5... view more (2007-12-26)

Certain diseases, birth defects may be linked to failure of protein recycling system
A group of signaling proteins known as Wnt - which help build the human body's skin, bone, muscle and other tissues - depend on a complex delivery and recycling system to ensure their transport to tissue-building cell sites, according to a study at Cincinnati Children's Hospital Medical Center.   view more (2007-12-21)

Fragile X retardation syndrome corrected in mice
Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation.   view more (2007-12-20)

Receptor protein appears to be key in breakdown of kidney filtration
Massachusetts General Hospital (MGH) researchers have identified a new molecular pathway that appears to be involved in urinary protein loss (proteinuria).   view more (2007-12-20)

New strategy to cut heart attack risk is effective in initial test
The first clinical trial of a new kind of drug to cut the risk of cardiovascular disease has been found safe and effective at dropping levels of "bad" low density lipoprotein (LDL) cholesterol by as much as 40 percent.   view more (2007-12-18)

Molecular pathway appears crucial in development of pulmonary fibrosis
A study led by Massachusetts General Hospital (MGH) researchers may have found a key mechanism underlying idiopathic pulmonary fibrosis (IPF), a usually fatal lung disease for which transplantation is the only successful treatment.   view more (2007-12-13)

Experts call for better research into link between women's hormones and mood disorders
Countless movies and TV shows make light of women's so-called "moodiness", often jokingly attributing it to their menstrual cycle or, conversely, to menopause.   view more (2007-12-13)

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