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New computational technique can predict drug side effects
Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process.   view more (2007-12-12)

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer
A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer.   view more (2007-12-12)

For the fruit fly, everything changes after sex
IMP Director Barry Dickson and his group are interested in the genetic basis of innate behaviour. They focus on the reproductive behaviour of the fruit fly Drosophila melanogaster. Two years ago, the team was able to identify the fruitless gene as a key regulator of mating behaviour.   view more (2007-12-11)

Study suggests nicotine addiction might be controlled by influencing brain mechanisms
There is a clear link between GABA - a chemical substance of the central nervous system that inhibits neurons in the brain - and nicotine dependence, according to a study presented today at the American College of Neuropsychopharmacology (ACNP) annual meeting.   view more (2007-12-10)

Knowing how ketamine impairs brain circuitry may lead to new therapies for schizophrenia
Scientists know that the drug ketamine - street name "Special K" - can induce schizophrenia-like symptoms in drug abusers. Ketamine is also used as an anesthetic and, more recently, as an antidepressant - raising concerns by researchers at the University of California, San Diego (UCSD)... view more (2007-12-07)

Pheromones Identified that Trigger Aggression between Male Mice
A family of proteins commonly found in mouse urine is able to trigger fighting between male mice, a study in the Dec. 6, 2007, issue of Nature has found.   view more (2007-12-06)

Refuted claims from observational studies often persist despite strong evidence against them
Prominent claims from observational studies of the cardiovascular benefits of vitamin E often continue to be supported in medical literature despite strong contradictory evidence from randomized trials.   view more (2007-12-05)

Children's Hospital researchers identify molecular 'switch' that could save very young lives
A team of researchers at Children's Hospital of Pittsburgh of UPMC have identified a molecular "switch" that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.   view more (2007-12-05)

Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
Blocking signals from a key molecular receptor that normally switches on the intestine's immune response but instead becomes too intense in the presence of stress and toxins may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature newborns.   view more (2007-12-03)

Breathe deep: Which patients could benefit from inhaled steroids in cystic fibrosis?
A specific variation in the glucocorticoid receptor gene is associated with lung disease progression in cystic fibrosis, research published this week in the online open access journal Respiratory Research reveals.   view more (2007-11-29)

Jefferson Scientists See Breast Cancer Gene Activity from Outside the Body
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body.   view more (2007-11-29)

Effects of progesterone on Alzheimer's disease
The first study on progesterone and Alzheimer's disease has found no clear preventive benefit for the widely prescribed hormone in an animal model.   view more (2007-11-28)

A new computational technique predicts side-effects of a major cancer drug
Researchers at the University of California San Diego have developed a novel computer technique to search for the side effects of major pharmaceuticals.   view more (2007-11-28)

Wake up and smell the sweat
Some people are oblivious to the odor in the locker room after a game, while others wrinkle their noses at the slightest whiff of sweat.   view more (2007-11-26)

The hormone of darkness: melatonin could hurt memory formation at night
What do you do when a naturally occurring hormone in your body turns against you? What do you do when that same hormone - melatonin - is a popular supplement you take to help you sleep? A University of Houston professor and his team of researchers may have some answers.   view more (2007-11-16)

Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
Pre-malignant mammary lesions in dogs and humans display many of the same characteristics, a discovery that could lead to better understanding of breast cancer progression and prevention for people and pets, said a Purdue University scientist from the School of Veterinary Medicine.   view more (2007-11-16)

Dartmouth researchers show effects of low dose arsenic on development
A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development.   view more (2007-11-15)

Global view shows link between endometrial cancer and vitamin D status
Using newly available data on worldwide cancer incidence, researchers at the Moores Cancer Center at University of California, San Diego (UCSD) have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B (UVB), and endometrial cancer.   view more (2007-11-15)

Two Proteins May Be Survival Markers in Some Breast Cancers
New research suggests that the presence or absence of two proteins may be important markers for long-term survival in some breast-cancer patients.   view more (2007-11-14)

LA BioMed research finds simpler way to assess breast cancer risk
A new, simpler model for predicting breast cancer risk in postmenopausal women appears to be as accurate as a more complicated method currently used to decide if women would benefit from medication to reduce their risk of getting cancer, according to research published today in the Journal of the... view more (2007-11-14)

Abnormal immune cells may cause unprovoked anaphylaxis
Two new clinical reports shed light on why some people suffer from recurrent episodes of idiopathic anaphylaxis--a potentially life-threatening condition of unknown cause characterized by a drop in blood pressure, fainting episodes, difficulty in breathing, and wheezing.   view more (2007-11-12)

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
The innovative new rheumatoid arthritis drug Actemra (tocilizumab) has been shown to significantly improve the signs and symptoms of rheumatoid arthritis (RA) in patients who failed to achieve an adequate response to traditional disease modifying agents (DMARDs).   view more (2007-11-09)

Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
Exposing estrogen-sensitive breast cancer cells to extracts of channel catfish caught in areas with heavy sewer and industrial waste causes the cells to multiply.   view more (2007-11-07)

Biomarker May Be an Early Predictor of Advanced Breast Cancer
Researchers have identified a molecule that may be more accurate than existing biological signposts used to predict which breast cancers will develop into advanced forms of the disease.   view more (2007-11-06)

Researchers discover new way to predict survival in older women with lung cancer
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a novel mechanism to predict survival in older women with early stage lung cancer. The finding may have significant implications for new treatment approaches.   view more (2007-11-02)
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