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SNPs affect folate metabolism in study of Puerto-Rican adults
Researchers at Tufts University have gained further understanding of the genomic basis for altered folate metabolism and the content of uracil in blood DNA.   view more (2008-11-11)

Genetic predictors of esophageal cancer identified
Researchers have identified 11 genotypes that may increase esophageal cancer risk, according to research published in the November issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.   view more (2008-11-05)

Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment
New clinical data show antiviral activity of TMC435, an investigational protease inhibitor (PI) being developed by Tibotec BVBA for the treatment of chronic hepatitis C virus (HCV) infection.   view more (2008-11-04)

DNA research taking guesswork out of finding the 'therapeutic window'
It's only spit, but what's inside your saliva may help solve a dosing dilemma facing doctors and patients.   view more (2008-10-24)

Study finds genomic changes in the brains of people who commit suicide
Are genes destiny? Alternatively, are we simply the products of our environment? There is a growing sense that neither of these two possibilities fully captures the essence of the risk for psychiatric disorders.   view more (2008-10-23)

Vitamin D deficiency may be more common in Parkinson's disease patients
Individuals with Parkinson's disease appear more likely to be vitamin D deficient than healthy adults of the same age or patients with Alzheimer's disease, according to a report in the October issue of Archives of Neurology, one of the JAMA/Archives journals.   view more (2008-10-14)

Traits produced by melanin may signal the bearer's capacity to combat free radicals
Some animal species have developed conspicuous traits produced by melanin pigments (for instance, dark manes in lions, black stripes in some birds and fishes).   view more (2008-10-06)

Genes influence effectiveness of weight-loss drug
Obese patients with a specific genetic make-up lose more weight when taking the weight loss drug sibutramine and undergoing behavioral therapy compared to those without this genetic make-up, reports a new study in Gastroenterology, the official journal of the American Gastroenterological... view more (2008-10-02)

Study reveals specific gene in adolescent men with delinquent peers
Birds of a feather flock together, according to the old adage, and adolescent males who possess a certain type of variation in a specific gene are more likely to flock to delinquent peers.   view more (2008-10-02)

Captive breeding introduced infectious disease to Mallorcan amphibians
A potentially deadly fungus that can kill frogs and toads was inadvertently introduced into Mallorca by a captive breeding programme that was reintroducing a rare species of toad into the wild, according to a new study published today in the journal Current Biology.    view more (2008-09-22)

Mate selection more biologically determined in some human populations
Some human populations may rely on biological factors in addition to social factors when selecting a mate. In a recent study, published September 12 in the open-access journal PLoS Genetics, scientists in China, France, and the United Kingdom report genomic data showing that immunity traits may be... view more (2008-09-12)

Pregnancy situations have impact on brain development in pre-term infants
Brain development in infants who are born very prematurely is still incomplete. Factors that cause premature birth may have an impact on the development of the premature infant's brain both during pregnancy and later on after birth.   view more (2008-08-28)

ETH Zurich study on salmonella self-destruction
ETH Zurich biologists, led by Professors Martin Ackermann and Wolf-Dietrich Hardt, in collaboration with Michael Doebeli of the University of British Colombia in Vancouver (CN), have been able to describe how random molecular processes during cell division allow some cells to engage in a... view more (2008-08-22)

New study replicates association between genetic variation and antidepressant treatment response
Pharmacogenetics, the study of genetic variation that influences an individual's response to drugs, is an important and growing focus in all of medical research, including psychiatry.   view more (2008-07-16)

Gaining ground on sickle cell disease
Although sickle cell disease is a single-gene disorder, its symptoms are highly variable. In a study published online July 14 by the Proceedings of the National Academy of Sciences, scientists at Children's Hospital Boston and the Dana Farber Cancer Institute (DFCI), in collaboration with the Broad... view more (2008-07-16)

Did the gene for ADHD help our nomadic ancestors?
An ADHD-associated version of the human gene DRD4 is linked to better health among nomadic tribesmen, but may cause malnourishment in their settled cousins, according to new research by a team directed by an anthropologist at the University of Wisconsin-Milwaukee (UWM).   view more (2008-06-17)

Low HDL cholesterol from gene variation not associated with increased risk of ischemic heart disease
Lower levels of high-density lipoprotein (HDL) cholesterol due to a gene mutation is not associated with an increased risk of ischemic heart disease, according to a study in the June 4 issue of JAMA.   view more (2008-06-04)

Courtship pattern shaped by emergence of a new gene in fruit flies
When a young gene known as sphinx is inactivated in the common fruit fly, it leads to increased male-male courtship, scientists report in the May 27, 2008, issue of the Proceedings of the National Academy of Sciences.   view more (2008-05-27)

Risk threshold of daily alcohol intake and drinking duration in liver injury?
Alcoholic threshold effect rather than a dose-response effect on mortality from alcohol-related liver injury. Alcohol intake, rather than the type of alcoholic beverage, was more significant to liver injury.   view more (2008-05-21)

How to increase the chances of remaining virus free Pakistani patients with HCV?
Hepatitis C is a health care problem all over the world, with 130 million patients infected the world over. The treatment is expensive and has variable results according to the genotype of the infecting virus.   view more (2008-05-21)

For children with sickle cell disease, lung disease is part of the package
Children with sickle cell disease (SCD) have a significantly sharper decline in lung function with age when compared to other children of the same race and age.   view more (2008-05-19)

How body size is regulated: International study discovers ten new genes related to human growth
Scientists are beginning to unravel the question why people distinctly vary in size.   view more (2008-05-12)

Anti-HBe may play a role in the progression of the disease of hepatitis B
Genotype D is found to be the only detected type in different clinical forms of HBV infections, including cirrhosis, among residents of southwestern Iran. A significant association between the presence of anti-HBe antibody and increasing ALT levels among either HBeAg-negative or HBeAg-positive... view more (2008-04-30)

Study verifies that cholesterol-associated gene variants can predict cardiovascular events
A study appearing in this week's New England Journal of Medicine confirms that a combination of gene variants previously associated with cholesterol levels does reflect patients' cholesterol levels and can signify increased risk of heart attack, stroke or sudden cardiac death.   view more (2008-03-20)

Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Heavier alcohol consumption increases the risk of ESCC. There are synergetic interactions among alcohol drinking and ALDH2, ADH1B, CYP2E1 genotypes.   view more (2008-03-13)
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