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Genetic predictors of esophageal cancer identified
Researchers have identified 11 genotypes that may increase esophageal cancer risk, according to research published in the November issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.   view more (2008-11-05)

MicroRNAs make for safer cancer treatments
Viruses -- long regarded solely as disease agents -- now are being used in therapies for cancer. Concerns over the safety of these so-called oncolytic viruses stem from their potential to damage healthy tissues.   view more (2008-10-27)

Short RNAs show a long history
MicroRNAs, the tiny molecules that fine-tune gene expression, were first discovered in 1993. But it turns out they've been around for a billion years.   view more (2008-10-02)

Tiny molecule helps control blood-vessel development, researchers find
The development and repair of heart tissue and blood vessels is intimately tied to a tiny piece of ribonucleic acid (RNA) that is found nowhere else in the body, researchers at UT Southwestern Medical Center have found.   view more (2008-08-13)

Gladstone scientists identify single microRNA that controls blood vessel development
Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.   view more (2008-08-12)

Hebrew University study opening new route for combating viruses
A unique technique for analyzing the function of microRNAs developed by a Hebrew University of Jerusalem doctoral student has led to the discovery of a new mechanism by which viruses evade the human immune system.   view more (2008-06-25)

How body size is regulated: International study discovers ten new genes related to human growth
Scientists are beginning to unravel the question why people distinctly vary in size.   view more (2008-05-12)

Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders.   view more (2008-05-12)

New genetic techniques to combat lung cancer
New results on genetic techniques that are helping doctors diagnose and treat lung cancer were released today at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association for the Study of Lung Cancer (IASLC) in... view more (2008-04-28)

Two suppressor molecules affect 70 genes in leukemia
By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.   view more (2008-04-25)

Yale scientists show that a microRNA can reduce lung cancer growth
A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle.   view more (2008-03-24)

Protein protects embryonic stem cells' versatility and self-renewal
A protein known as REST blocks the expression of a microRNA that prevents embryonic stem cells from reproducing themselves and causes them to differentiate into specific cell types, scientists at The University of Texas M. D. Anderson Cancer Center report in the journal Nature.   view more (2008-03-24)

Role for microRNAs in limb regeneration
In the March 15th issue of G&D, Dr. Kenneth Poss (Duke University Medical Center) and colleagues reveal that microRNA depletion is a necessary step in tissue regeneration - a discovery with interesting implications for their use in regenerative medicine.   view more (2008-03-17)

MicroRNAs help zebrafish regenerate fins
Biologists have discovered a molecular circuit breaker that controls a zebrafish's remarkable ability to regrow missing fins, according to a new study from Duke University Medical Center.   view more (2008-03-17)

Short RNA strand helps exposed skin cells protect body from bacteria, dehydration and even cancer
Every minute, 30,000 of our outermost skin cells die so that we can live. When they do, new cells migrate from the inner layer of the skin to the surface of it, where they form a tough protective barrier.   view more (2008-03-03)

Single microRNA fine-tunes innate immune response
A single microRNA, microRNA-223, in mice controls the production and activation of granulocytes, white blood cells essential for host defense against invading pathogens.   view more (2008-02-20)

Dartmouth researchers find the root of the evolutionary emergence of vertebrates
Dartmouth College researchers and colleagues from the University of Bristol in the U.K. have traced the beginnings of complex life, i.e. vertebrates, to microRNA. The researchers argue that the evolution of microRNAs, which regulate gene expression, are behind the origin of early vertebrates.   view more (2008-02-12)

Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries.   view more (2008-02-12)

Molecules might identify high-risk acute-leukemia patients
New research suggests that certain small molecules used by cells to control the proteins they make might also help doctors identify adult acute-leukemia patients who are likely to respond poorly to therapy.   view more (2008-01-16)

MIT reports new twist in microRNA biology
MIT scientists have found a new way that DNA can carry out its work that is about as surprising as discovering that a mold used to cast a metal tool can also serve as a tool itself, with two complementary shapes each showing distinct functional roles.   view more (2008-01-14)

Small RNAs can prevent spread of breast cancer
Howard Hughes Medical Institute researchers have identified small pieces of ribonucleic acid (RNA) that suppress the spread of breast cancer to the lungs and bone. The new research shows that the most invasive and aggressive human breast cancer tumors are missing three critical microRNA molecules.   view more (2008-01-10)

Molecules can block breast cancer's ability to spread
Researchers have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.   view more (2008-01-10)

Making sense of antisense microRNAs
Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila.   view more (2008-01-02)

CSHL scientists identify and repress breast cancer stem cells in mouse tissue
By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory (CSHL) report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue - cells that are widely thought to give rise to cancer.   view more (2007-12-18)

Scientists discover new role for miRNA in leukemia
Scientists here have found that mini-molecules called micro-RNA may play a critical role in the progression of chronic myeloid leukemia (CML) from its more treatable chronic phase to a life-threatening phase, called blast crisis.   view more (2007-12-10)
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