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Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
Defects on cell-surface sugars may promote the short-term inflammation and long-term neurodegeneration that occurs in the central nervous system of multiple sclerosis patients, according to University of California, Irvine researchers.   view more (2007-09-21)

Cell death in sparrow brains may provide clues in age-related human diseases
A remarkable change takes place in the brains of tiny songbirds every year, and some day the mechanism controlling that change may help researchers develop treatments for age-related degenerative diseases of the brain such as Parkinson's and dementia.   view more (2007-09-18)

3-D fruit fly images to benefit brain research
The fragile head and brain of a fly are not easy things to examine but MRC scientists have figured out how to make it a little simpler. And they hope their research will shed light on human disease.   view more (2007-09-05)

HIV is a 'double hit' to the brain
New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia.   view more (2007-08-16)

Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
Scientists have discovered a key protein in the toxic brain pathway that leads to fragile X tremor/ataxia syndrome (FXTAS), an inherited neurodegenerative disorder.   view more (2007-08-16)

The UAB heads a European research project on proteases and pathological processes
A research group of the UAB Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology, directed by Francesc Xavier Avilés, is the coordinator of a European project aimed at studying proteases with fluorescent molecules that allow their monitoring... view more (2007-07-18)

Natural compound and exercise boost memory in mice
A natural compound found in blueberries, tea, grapes, and cocoa enhances memory in mice, according to newly published research. This effect increased further when mice also exercised regularly.   view more (2007-05-30)

DNA repair proteins monitored at double-strand break
Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.   view more (2007-05-10)

Scientists encourage cells to make a meal of Huntington's disease
Scientists have developed a novel strategy for tackling neurodegenerative diseases such as Huntington's disease: encouraging an individual's own cells to "eat" the malformed proteins that lead to the disease.   view more (2007-05-08)

Enhanced environment restores memory in mice with neurodegeneration
Mice whose brains had lost a large number of neurons due to neurodegeneration regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli.   view more (2007-04-30)

Blocking immune cell action increases Alzheimer's-associated protein deposits
The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder.   view more (2007-03-28)

Protein sensor for fatty acid buildup in mitochondria
Just as homes have smoke detectors, cells have an enzyme that responds to a buildup of fatty acids by triggering the production of a key molecule in the biochemical pathway that breaks down these fatty acids, according to investigators at St. Jude Children's Research Hospital.   view more (2007-02-15)

Grape expectations for healthier wine
A new technique that uses ozone to preserve grapes could help prevent allergies and boost healthy compounds at the same time, reports Jennifer Rohn in Chemistry & Industry, the magazine of the SCI.   view more (2007-02-12)

Insulin receptor stops progression of Alzheimer's disease
Stimulation of a receptor in the brain that controls insulin responses has been shown to halt or diminish the neurodegeneration of Alzheimer's disease, providing evidence that the disease can be treated in its early stages.   view more (2006-09-22)

Untangling a pathology of Alzheimer's
Researchers have uncovered what appears to be a natural protective mechanism against a central cause of neuronal death in Alzheimer's and similar neurodegenerative diseases.   view more (2006-09-07)

3-D forms link antibiotic resistance and brain disease
The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital.   view more (2006-08-21)

A probable cause for Parkinson's?
Parkinson's, Alzheimer's, Lou Gehrig's disease and other brain disorders are among a growing list of maladies attributed to oxidative stress, the cell damage caused during metabolism when the oxygen in the body assumes ever more chemically reactive forms.   view more (2006-06-28)

Finding a cellular Neverland: How stem cells stay childlike
espite their celebrated "immortality," the capacity of embryonic stem (ES) cells for endless division has its limits. After a very extended childhood spent dividing in a culture dish, even stem cells tend to grow up and assume adult roles as workaday nerve, muscle, or blood cells, never... view more (2006-06-27)

Rare disease's gene may illuminate major disorders
Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.   view more (2006-06-19)

Salk and Stanford teams join forces to reveal two paths of neurodegeneration
Wiring the developing brain is like creating a topiary garden. Shrubs don't automatically assume the shape of ornamental elephants, and neither do immature nerve cells immediately recognize the "right" target cell. Abundant foliage, either vegetal or neuronal, must first sprout and then... view more (2006-06-15)

Mechanism for neurodenegerative diseases linked to transport proteins
Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.   view more (2006-06-09)

Transcription factor protein's role in cell death, neurodegeneration and schizophrenia
Researchers at the University of Pennsylvania School of Medicine discovered that a protein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein -— typically active in the nucleus — could play a role in cell death and... view more (2006-06-08)

Research suggests cause of neurodegeneration in Huntington's disease
The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.   view more (2006-05-31)

New compound reduces stroke damage
A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms.   view more (2006-05-16)

Scientists discover possible link between oxidative stress and non-hereditary degenerative disease
The irreversible neurological degeneration associated with Parkinson's and Alzheimer's diseases may be the consequence of oxidative stress-the imbalance of antioxidants and pro-oxidants in cells.   view more (2006-04-28)
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