Stress-induced changes in brain circuitry linked to cocaine relapse
Stress-evoked changes in circuits that regulate serotonin in certain parts of the brain can precipitate a low mood and a relapse in cocaine-seeking, based on mouse studies published online this week in the Proceedings of the National Academy of Sciences. view more (2009-10-30)
Infant pain, adult repercussions
Scientists at Georgia State University have uncovered the mechanisms of how pain in infancy alters how the brain processes pain in adulthood. view more (2009-09-28)
Instanyl sets new standard in management of breakthrough cancer pain
New data presented today further demonstrate the efficacy of Instanyl in management of breakthrough cancer pain. The data which were presented at the 6th congress of the European Federation of Chapters of the International Association for the Study of Pain (EFIC) are from a multinational, crossover trial comparing Instanyl with oral transmucosal... view more... (2009-09-11)
Rats Move Toward the Food but Do Not Eat
Scientists led a rat to the fatty food, but they couldn't make it eat. Using an animal model of binge eating, University of Missouri researchers discovered that deactivating the basolateral amygdala, a brain region involved in regulating emotion, specifically blocked consumption of a fatty diet. Surprisingly, it had no effect on the rat wanting... view more... (2009-09-09)
Researchers find genetic link between physical pain and social rejection
UCLA psychologists have determined for the first time that a gene linked with physical pain sensitivity is associated with social pain sensitivity as well. view more (2009-08-18)
Chinese acupuncture affects brain's ability to regulate pain, UM study shows
Acupuncture has been used in East-Asian medicine for thousands of years to treat pain, possibly by activating the body's natural painkillers. But how it works at the cellular level is largely unknown. view more (2009-08-10)
Nerve-block anesthesia can improve surgical recovery, even outcomes
When planning for surgery, patients too often don't consider the kind of anesthesia they will receive. In fact, the choice of anesthesia can improve recovery, even outcomes. view more (2009-08-05)
Researchers identify potential patient safety risks among methadone maintenance treatment patients
Boston Medical Center (BMC) researchers have identified potential safety risks among methadone maintenance treatment (MMT) patients due to the quantity and accuracy of medical record documentation. view more (2009-07-09)
A comprehensive review of addiction to prescription painkillers among patients and physicians
Chemical dependency and recovery in patients and physicians are closely examined in a series of articles and editorials in the July 2009 issue of Mayo Clinic Proceedings. view more (2009-07-08)
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor... view more... (2009-04-23)
New information points to safer methadone use for treatment of pain and addiction
New findings may significantly improve the safety of methadone, a drug widely used to treat cancer pain and addiction to heroin and other opioid drugs, according to researchers at Washington University School of Medicine in St. Louis and the University of Washington in Seattle. view more (2009-03-03)
New guidelines for prescribing opioid pain drugs published
A prestigious panel of pain-management experts representing the American Pain Society (APS) www.ampainsoc.org and the American Academy of Pain Medicine (AAPM) has published the first comprehensive clinical practice guideline to assist clinicians in prescribing potent opioid pain medications for patients with chronic non-cancer pain. view more (2009-02-10)
New guideline for prescribing opioid pain drugs published
A national panel of pain management experts representing the American Pain Society (APS) and the American Academy of Pain Medicine (AAPM) has published the first comprehensive, evidence-based clinical practice guideline to assist clinicians in prescribing potent opioid pain medications for patients with chronic non-cancer pain. view more (2009-02-09)
Study first to pinpoint why analgesic drugs may be less potent in females than in males
Investigators at Georgia State University's Neuroscience Institute and Center for Behavioral Neuroscience are the first to identify the most likely reason analgesic drug treatment is usually less potent in females than males. view more (2008-12-23)
Sugar can be addictive, Princeton scientist says
A Princeton University scientist will present new evidence today demonstrating that sugar can be an addictive substance, wielding its power over the brains of lab animals in a manner similar to many drugs of abuse. view more (2008-12-10)
Extended-treatment with combination medication for opioid-addicted youths shows benefit
Adolescents addicted to opioids who received continuing treatment with the combination medication buprenorphine-naloxone had lower rates of testing positive or reporting use of opioids compared to youths who went through a short-term detoxification program using the same medication, according to a study in the November 5 issue of JAMA. view more (2008-11-05)
Post-marketing studies finding adverse events in drugs used in children
The Food and Drug Administration Modernization Act (FDAMA, 1997), designed to stimulate more drug safety studies in children, has resulted in more than 130 label changes since its inception nearly six years ago, according to researchers at Duke Children's Hospital. view more (2008-09-02)
Study examines use of opioids
Researchers from Boston University's Slone Epidemiology Center have found that in a given week, over 10 million Americans are taking opioids, and more than 4 million are taking them regularly (at least five days per week, for at least four weeks). These findings appear in the August 31 issue of the journal Pain. view more (2008-08-28)
Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGFr) axis for its action. view more (2008-07-28)
Study shows high rates, rising costs of alcohol/drug disorders in hospitalized patients
Fourteen percent of patients admitted to the hospital have alcohol/drug abuse and addiction (ADAA) disorders, costs for which have risen sharply in recent years, according to a study in the June issue of the Journal of Substance Abuse Treatment (JSAT). view more (2008-06-25)
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