Recent Plasminogen Current Events | Plasminogen News
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Experimental treatment halts hypoxic-ischemic brain injury in newborns
Inhibiting an enzyme in the brains of newborns suffering from oxygen and blood flow deprivation stops a type of brain damage that is a leading cause of cerebral palsy, mental retardation and death, according to researchers at Cincinnati Children's Hospital Medical Center. view more (2009-07-29)
One Disease, Two Effects: Stroke
Congress is expected to take up legislation this summer aimed at improving the nation's healthcare system. Whatever the shape of the final bill, it will have at least some impact on one of the three leading causes of death in the U.S.: stroke. view more (2009-07-16)
UT Houston researchers use stroke patient's own stem cells in trial for first time Phase I trial will enroll 10 patients
For the first time in the United States, a stroke patient has been intravenously injected with his own bone marrow stem cells as part of a research trial at The University of Texas Medical School at Houston. view more (2009-04-16)
Patients who wake up with stroke may be candidates for clot-busters
Giving clot-busting drugs to patients who wake up with stroke symptoms appears to be as safe as giving it to those in the recommended three-hour window, according to researchers at The University of Texas Medical School at Houston. view more (2009-03-13)
Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes
Researchers at the University of Vermont Cardiovascular Research Institute, Colchester, Vermont have found that increased expression in the heart of plasminogen activator inhibitor type-1 (PAI-1) is profibrotic. view more (2009-02-24)
Stroke therapy window might be extended past nine hours for some
Some patients who suffer a stroke as a result of a blockage in an artery in the brain may benefit from a clot-busting drug nine or more hours after the onset of symptoms. The findings are published in the online edition of Radiology. view more (2009-02-09)
Blocking toxic effects could make clot-buster safer
Since the introduction of the life-saving clot-busting drug tPA more than a decade ago, evidence has been accumulating that tPA (tissue-type plasminogen activator) can be a double-edged sword for a brain affected by stroke. view more (2009-01-23)
Apolipoprotein(a): A natural regulator of inflammation
In a study to be published in the January 09 issue of Experimental Biology and Medicine, Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. view more (2008-12-29)
Ultrasound waves aid in rapid treatment of DVT
The use of ultrasound waves for deep vein thrombosis (DVT) may help dissolve blood clots in less time than using clot-busting drugs alone, according to researchers at Emory University. view more (2008-11-24)
Friend or foe? How the body's clot-busting system speeds up atherosclerosis
Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating... view more... (2008-10-31)
Protein complementarity may offer new insights into autoimmune diseases
The discovery of "complementary" antibodies against plasminogen in patients with blood vessel inflammation caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs) may lead to new approaches to research, testing, and treatment of ANCA vasculitis and other autoimmune diseases, suggests a paper in the December Journal of the American... view more... (2008-08-14)
Elevated biomarkers predict risk for prostate cancer recurrence
A simple blood test screening for a panel of biomarkers can accurately predict whether a patient who has had prostate cancer surgery will have a recurrence or spread of the disease. view more (2008-06-26)
Predicting the risk of a common fungal infection after stem cell transplantation
In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients. view more (2008-06-20)
Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a ¡¥decoy' receptor, binding growth factors that promote the progression of cancer. view more (2008-05-29)
Men at increased risk of death from pneumonia compared to women
Men who come to the hospital with pneumonia generally are sicker than women and have a higher risk of dying over the next year, despite aggressive medical care. view more (2008-05-19)
Researchers fine-tune clot-busting treatment for bleeding in brain
A multicenter study led by Johns Hopkins doctors has fine-tuned the dosage and timing for administering clot-busting tissue plasminogen activator (tPA) to patients with strokes caused by bleeding within the brain. The treatment, as reported this week at the European Stroke Conference in Nice, France, has been shown to dramatically decrease death... view more... (2008-05-14)
Lung damage in babies with congenital heart disease under study
Trying to understand and stop the collateral lung damage that can occur in babies with congenital heart disease is the focus of a new study. view more (2008-03-11)
Weill Cornell Team Discovers How Brain's Own tPA Helps Regulate Blood Flow to Neurons
The human brain contains its own store of a powerful enzyme (and stroke drug) called tissue plasminogen activator (tPA), which appears to be a key regulator of blood flow to brain cells, a team at the Weill Cornell Medical College in New York City reports. view more (2008-01-18)
Air pollution linked to cardiovascular risk indices in healthy young adults
Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction. view more (2007-08-15)
Preclinical Study Links Gene to Brain Aneurysm Formation
University of Cincinnati (UC) neurovascular researchers have identified a gene that-when suppressed or completely absent-may predispose a person to brain aneurysms. view more (2007-08-08)
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