Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
Researchers at UCLA's Jonsson Comprehensive Cancer Center showed for the first time that the loss or decreased expression of the tumor suppressor gene PTEN plays a central role in the malignant transformation of benign nerve tumors called neurofibromas into a malignant and extremely deadly form of sarcoma. view more (2009-10-13)
Certain cancers more common among HIV patients than non-HIV patients
Researchers at UT Southwestern Medical Center have found that non-AIDS-defining malignancies such as anal and lung cancer have become more prevalent among HIV-infected patients than non-HIV patients since the introduction of anti-retroviral therapies in the mid-1990s. view more (2009-09-25)
New hope for deadly childhood bone cancer
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have shed new light on Ewing's sarcoma, an often deadly bone cancer that typically afflicts children and young adults. view more (2009-08-31)
UCSF researchers identify new drug target for Kaposi's Sarcoma
UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deemed too difficult to attain. view more (2009-07-30)
New strategy in tumor treatment
A new strategy proposed by researchers at Dartmouth Medical School and Amtek, Hanover, NH may treat tumors that do not respond to conventional treatment. view more (2009-07-20)
U of M Researchers Find Childhood Cancer Risk Rises with Mother's Age
Research from the Masonic Cancer Center, University of Minnesota indicates that a baby born to an older mother may have a slightly increased risk for many of the cancers that occur during childhood. view more (2009-07-15)
GUMC discovery highlights new direction for drug discovery
In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults. view more (2009-07-06)
Caucasians are at higher risk of developing Ewing's sarcoma than other races
The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing's sarcoma. view more (2009-06-22)
Research uncovers clues to virus-cancer link
In a series of recently-published articles, a research team from the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center has uncovered clues to the development of cancers in AIDS patients. view more (2009-06-18)
Using PET/CT imaging, UCLA researchers can tell after a single treatment if chemotherapy is working
Oncologists often have to wait months before they can determine whether a treatment is working. Now, using a non-invasive method, researchers at UCLA's Jonsson Comprehensive Cancer Center have shown that they can determine after a single cycle of chemotherapy whether the toxic drugs are killing the cancer or not. view more (2009-04-15)
U-M researchers discover new genes that fuse in cancer
Using new technologies that make it easier to sequence the human genome, researchers at the University of Michigan Comprehensive Cancer Center have identified a series of genes that become fused when their chromosomes trade places with each other. view more (2009-01-12)
Promising new treatment option for women with recurrent ovarian cancer
Combining the new drug trabectedin with pegylated liposomal doxorubicin provides clinical benefit to women with relapsed ovarian cancer, according to new results presented at the 33rd Congress of the European Society for Medical Oncology (ESMO) in Stockholm. view more (2008-09-16)
International team reveals first prognosticator of survival in aggressive cancer
The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS). view more (2008-09-04)
Dual functions of gene revealed, for better and for worse
Researchers at WEHI have pinpointed the function of a potent cancer gene. The gene, known as "ERG", has long been associated with a range of human malignancies, including leukemia and sarcoma. American scientists showed in 2005 that ERG is mutated in more than half of all prostate cancers. view more (2008-05-27)
Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling events in cells by phosphorylating and modulating... view more... (2008-05-05)
Potential viral therapy weapon for difficult cancers is safe and effective in study
Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice. view more (2008-04-23)
In lab study, researchers find molecule that disrupts Ewing's sarcoma oncogene
Researchers at Georgetown University Medical Center have found a small molecule they say can block the action of the oncogene that causes Ewing's sarcoma, a rare cancer found in children and young adults. If further studies continue to prove beneficial, they say the novel agent could be the first targeted therapy to treat the disease, which can... view more... (2008-04-14)
Study proposes new theory of how viruses may contribute to cancer
A new study suggests that viruses may contribute to cancer by causing excessive death to normal cells while promoting the growth of surviving cells with cancerous traits. view more (2007-10-24)
An AIDS-related virus reveals more ways to cause cancer, Penn researchers find
Researchers at the University of Pennsylvania School of Medicine have shed new light on how Kaposi's Sarcoma-associated Herpes Virus (KSHV) subverts normal cell machinery to cause cancer. view more (2007-10-09)
Cancer researchers seek safe reduction of radiotherapy
University of Manchester scientists will discuss their research aimed at reducing the side effects of radiotherapy without decreasing its effectiveness at the National Cancer Research Institute conference in Birmingham. view more (2007-10-03)
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