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Penn Study Provides First Clear Idea of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a... view more... (2009-11-13)

A master mechanism for regeneration?
Biologists long have marveled at the ability of some animals to re-grow lost body parts. Newts, for example, can lose a leg and grow a new one identical to the original. Zebrafish can re-grow fins.   view more (2009-10-20)

Fish fend off invading germs with an initial response similar to the one found in people
Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms.   view more (2009-09-24)

With a flash of light, a neuron's function is revealed
There's a new way to explore biology's secrets. With a flash of light, scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California, Berkeley zeroed in on the type of neural cell that controls swimming in larval zebrafish.   view more (2009-09-17)

Pitt team finds molecule that regulates heart size by using zebrafish screening model
Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart.   view more (2009-07-06)

Embryology Study Offers Clues to Birth Defects
Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development.   view more (2009-06-10)

Hydrogen peroxide marshals immune system
When you were a kid your mom poured it on your scraped finger to stave off infection.   view more (2009-06-04)

Zebrafish provide a model for cancerous melanoma in humans
In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.   view more (2009-05-26)

A surprise 'spark' for pre-cancerous colon polyps
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors to cancerous tumors.   view more (2009-05-15)

What do blood stem cells need to grow? Blood flow
Blood stem cells literally go with the flow, according to a new report published as an immediate early publication in the journal Cell, a Cell Press journal, on May 13th.   view more (2009-05-14)

Embryo's heartbeat drives blood stem cell formation
Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood.   view more (2009-05-14)

Researchers find lack of key molecule leads to deafness
Researchers have identified tiny molecules that may lead to big breakthroughs in the treatment of hearing loss and deafness.    view more (2009-04-17)

Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
Extensive death of nerve cells leads to severe dementia in patients with Alzheimer's disease. Until now, it has only been possible to investigate the neuronal devastation in post mortem animal models, and by using complicated methods.   view more (2009-04-15)

Mutated gene in zebrafish sheds light on blindness in humans
Among zebrafish, the eyes have it. Inside them is a mosaic of light-sensitive cells whose structure and functions are nearly identical to those of humans.   view more (2009-03-25)

MicroRNA undermines tumor suppression
Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53, While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of... view more... (2009-03-18)

Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
One of the small regulatory molecules, named microRNA-125b, is a novel regulator of p53, an important protein that safeguards cells against cancers, Singapore and U.S. scientists report in the March 17, 2009 issue of the journal Genes & Development.   view more (2009-03-18)

Big-Hearted Fish Reveals Genetic Underpinnings of Enigmatic Cardiovascular Condition, According to Penn Study
Researchers at the University of Pennsylvania School of Medicine have unlocked the mystery of a puzzling human disease and gained insight into cardiovascular development, all thanks to a big-hearted fish.   view more (2009-02-26)

Newly found enzymes may play early role in cancer
Researchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors.   view more (2008-12-29)

Mutations common to cancer and developmental disorder examined in a novel disease model
New research sheds light on a common link between tumor formation and Costello Syndrome, an inherited developmental disorder in which patients have cardiac defects, mild mental retardation, and face-shape abnormalities.   view more (2008-12-22)

International team discovers gene associated with epilepsy
A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy.   view more (2008-11-18)
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