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Cognitive impairment appears to be common in ALS patients In a study of 40 patients with amyotrophic lateral sclerosis (ALS), about one-third showed evidence of cognitive impairment, but these deficits did not appear to be related to survival. view more (2006-03-14)
Cerebrospinal fluid used to deliver therapeutics for Lou Gehrig's disease to brain Researchers from the University of California, San Diego have shown that instead of trying to deliver therapeutic agents for neurodegenerative diseases across the highly impermeable blood-brain barrier via the blood, therapeutic molecules known as antisense oligonucleotides can be delivered to the brain and spinal cord through the cerebrospinal... view more... (2006-07-28)
Growth factor stimulates rapid extension of key motor neurons in brain A growth factor known to be important for the survival of many types of cells stimulates rapid extension of corticospinal motor neurons - critical brain cells that connect the cerebral cortex with the spinal cord and that die in motor neuron diseases like amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). view more (2006-11-06)
Understanding the Noxious cause of Lou Gehrig's disease There is no known cure for amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig disease and motor neuron disease. view more (2007-09-14)
Spinal fluid proteins signal Lou Gehrig's disease High levels of certain proteins in the spinal fluid could signal the onset of Lou Gehrig's disease, according to researchers. The discovery of these biomarkers may lead to diagnostic kits for early diagnosis, accurately measuring the progression of the disease and monitoring the effects of treatment. view more (2009-01-29)
Mayo Clinic study unveils unprecedented method to predict ALS, Parkinson's disease A new Mayo Clinic study details an unprecedented method to predict brain aging disorders such as amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) and Parkinson's disease. view more (2008-01-16)
Discoveries should aid research into cause of ALS Two teams of researchers at Northwestern University have found a novel pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) at the molecular level. view more (2006-04-26)
Researchers develop marker that identifies energy-producing centers in nerve cells A protein that causes coral to glow is helping researchers at the University of Maryland School of Medicine to light up brain cells that are critical for the proper functioning of the central nervous system. view more (2007-02-02)
First Look at an Enzyme Target for Antibacterial and Cancer Drugs The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. view more (2007-12-21)
A glimmer of hope in the struggle against neurodegenerative diseases: the virtues of proteins that can save dying neurons Diseases characterized by neurodegeneration affect individuals over 50 years of age and they attack one particular class of neurons in the brain or spinal cord. The research interest of Professor Ann Kato and her team is principally focalized on ALS in which there is a progressive paralysis caused by the destruction of motor neurons which exist in... view more... (2002-01-25)
Stem cells provide new tool for studying disease and identifying ALS drugs Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease. view more (2007-04-17)
First international gene screen for typical ALS is on track The largest-scale search for genes that underlie sporadic amyotrophic lateral sclerosis (ALS), the most common form of the disease, has crossed its first hurdle with the successful compiling of genetic information on more than 1,000 patients and controls. view more (2006-11-29)
UCLA, Italian chemists move closer to solving Lou Gehrig's disease mystery Chemists from UCLA and the University of Florence in Italy may have solved an important mystery about a protein that plays a key role in a particular form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a progressive, fatal neurodegenerative disorder that strikes without warning. view more (2007-06-28)
Loss of gene leads to protein splicing and buildup of toxic proteins in neurons Researchers at Mayo Clinic in Jacksonville have discovered how loss of a gene can lead to accumulation of toxic proteins in the brain, resulting in a common dementia, and they say this mechanism may be important in a number of age-related neurological disorders. view more (2007-09-28)
Drinking and driving -- Immediate removal of a driver's license saves hundreds of lives per year Alcohol-impaired driving causes roughly 17,000 deaths per year, according to a 2006 study. While 46 states will suspend the driver's licenses of those caught driving while impaired (DWI), nine states do not have immediate license-revocation laws. view more (2007-07-25)
UC San Diego Physicists Reveal Secrets of Newest Form of Carbon Using one of the world's most powerful sources of man-made radiation, physicists from UC San Diego, Columbia University and Lawrence Berkeley National Laboratory have uncovered new secrets about the properties of graphene-a form of pure carbon that may one day replace the silicon in computers, televisions, mobile phones and other common electronic... view more... (2008-06-11)
Gene hunters close in on Lou Gehrig's disease In the first genome-wide search for the genetic roots of the most common form of amyotrophic lateral sclerosis (ALS), Johns Hopkins scientists have newly identified 34 unique variations in the human genetic code among 276 unrelated subjects with ALS. view more (2007-02-21)
Unexpected similarities between raindrops and proteins Raindrops and proteins seem to have a lot in common. This has been shown in a new study by scientists at Ume'å University in Sweden. The principle behind the formation of raindrops is very similar to how proteins fold. This knowledge is vital to our understanding of neurodegenerative diseases like ALS. These findings have been published in... view more... (2004-05-26)
Protein plays Jekyll and Hyde role in Lou Gehrig's disease Amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig's disease, is a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord that control muscle movements from walking and swallowing to breathing. In a groundbreaking study this week in PLoS Biology, Brandeis and Harvard Medical School... view more... (2008-07-29)
Genetics of ALS progression An upcoming paper from Drs. Hidenori Ichijo and Hideki Nishitoh (The University of Tokyo) and colleagues lends new and valuable insight into the genetics of ALS. view more (2008-06-02)
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