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Canadian cardiology team clears the way for lifesaving breast cancer treatment
A team of Canadian cardiologists, in collaboration with oncologists, are playing an important role in the war against breast cancer Dr. Michael McDonald told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society. view more (2009-10-26)
Disinfectants can make bacteria resistant to treatment
Chemicals used in the environment to kill bacteria could be making them stronger, according to a paper published in the October issue of the journal Microbiology. Low levels of these chemicals, called biocides, can make the potentially lethal bacterium Staphylococcus aureus remove toxic chemicals from the cell even more efficiently, potentially... view more... (2008-10-06)
Stopping unwanted cell death: Implications for drug discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. view more (2008-04-14)
Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems. view more (2006-07-19)
COX-2 inhibitor could be safest anti-inflammatory drug for older people (p 1751)
A Canadian study involving over 130,000 older people in this week's issue of THE LANCET shows how the anti-inflammatory cyclo-oxygenase-2 (COX-2) inhibitor celecoxib may have a lower risk of congestive heart failure compared with other non-steroidal anti-inflammatory drugs. Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are... view more... (2004-05-26)
New information points to safer methadone use for treatment of pain and addiction
New findings may significantly improve the safety of methadone, a drug widely used to treat cancer pain and addiction to heroin and other opioid drugs, according to researchers at Washington University School of Medicine in St. Louis and the University of Washington in Seattle. view more (2009-03-03)
Abertay initiative promises greener future for golf
Scotland's golf courses can look forward to a greener future thanks to a new initiative launched today by the University of Abertay Dundee. Golf Solutions brings together environmental scientists, plant biotechnologists, microbiologists, computer specialists and other experts at Abertay to offer golf course managers new technologies for reducing... view more... (2004-03-21)
Use of acid-suppressive medications associated with increased risk of hospital-acquired pneumonia
Hospitalized patients who receive acid-suppressive medications such as a proton-pump inhibitor have a 30 percent increased odds of developing pneumonia while in the hospital. view more (2009-05-27)
Potential Lung Disease Biomarkers Yield Clues to COX-2 Inhibitor Side Effects
In searching for a simple way to identify individuals with smoking-related lung injury, scientists at Weill Cornell Medical College have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 inhibitors increases the risk of heart problems among users. view more (2009-04-30)
Aminoguanidine: An attractive line as a multi-modal avenue to overcome tumor
Aminoguanidine is a compound that exerts multiple biological actions. Aminoguanidine has well described antioxidant properties and is also an inhibitor of nitric oxide synthases, the enzymes that produce nitric oxide. view more (2009-03-09)
Novel enzyme inhibitor paves way for new cancer drug
Combining natural organic atoms with metal complexes, scientists at The Wistar Institute have developed a new type of enzyme inhibitor capable of blocking a biochemical pathway that plays a key role in cancer development. view more (2008-05-16)
Green tea and COX-2 inhibitors combine to slow growth of prostate cancer
Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer. view more (2007-03-01)
Researchers Debate Recreational Use of PDE-5 Inhibitors
Leaders in the field of sexual medicine will actively debate the use of oral pills for erectile dysfunction (ED) at the 7th Congress of the European Society for Sexual Medicine in London, UK. view more (2004-12-01)
Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart. Not only that, but other similarly based drugs - called tyrosine kinase inhibitors - could lead to heart problems as well. view more (2006-07-24)
Van Andel Institute Study Rules Out Transcriptional Coactivators as Useful Herpes Antiviral Drug Targets
Researchers at Van Andel Research Institute (VARI) have determined that the herpes simplex virus type 1 (HSV-1) does not require transcriptional coactivators for viral gene expression early in the infection process. The finding is significant in determining that, in contradiction to earlier models, chemical inhibitors of these cellular proteins... view more... (2009-03-26)
Study finds cardiac toxicity rates high with herceptin use
The first study to look at "real world" use of Herceptin in advanced breast cancer patients found a higher incidence of cardiac toxicity - 28 percent of patients treated - than clinical trials of the drug have reported to date, but also concluded that the majority of this heart damage could be reversed with treatment. view more (2006-08-15)
Organic & Biomolecular Chemistry
First Advance Articles Now Available Free Online The first issue of Organic & Biomolecular Chemistry, formed from the merger and strategic development of Perkin Transactions 1 & 2, will be published on 10 January 2003. The electronic version will go up on 23 December 2002. Barbara Imperiali, Francois Diederich, Ben Feringa and Chi-Huey... view more... (2002-12-05)
Prescription painkillers effective in patients with dormant inflammatory bowel disease
According to two studies published today in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, prescription painkillers are effective in easing the pain of patients with dormant inflammatory bowel disease (IBD) and are not likely to cause symptom flare-ups in IBD patients in remissions. view more (2006-02-03)
Penn studies point to strategies for reducing painful breast cancer drug side effects
Aromatase inhibitors, the same drugs that have buoyed long-term survival rates among breast cancer patients, also carry side effects including joint pain so severe that many patients discontinue these lifesaving medicines. view more (2009-09-29)
Drug discovery process more accurate, less expensive using novel mass spectrometry application
Cancer and cell biology experts at the University of Cincinnati (UC) have developed a new mass spectrometry-based tool they say provides more precise, cost-effective data collection for drug discovery efforts. view more (2009-09-18)
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