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Key finding in rare muscle disease
The finding is in the current issue of Annals of Neurology, a leading international neurology journal, in work led by Professor Nigel Laing and Dr Kristen Nowak of the Laboratory for Molecular Genetics at the Western Australian Institute for Medical Research (WAIMR) and done in collaboration with a... view more (2007-01-18)

How actin networks are actin'
Dynamic networks of growing actin filaments are critical for many cellular processes, including cell migration, intracellular transport, and the recovery of proteins from the cell surface.   view more (2008-01-03)

Wound Healing - Discovery Of A New Therapeutic Strategy Against Hypertrophic Scarring
Wound healing appears generally a banal event, but in a certain proportion of cases it evolves inappropriately in hypertrophic scars resulting in skin and organ deformations. This is due to an excess of wound contraction, a phenomenon that generally helps to close the wound. Hypertrophic scarring... view more (2002-05-13)

Penn researchers discover 'modus operandi' of heart muscle protein
Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called leiomodin (Lmod) promotes the assembly of an important heart muscle protein called actin. What's more, Lmod directs the assembly of actin to form the pumping unit of the heart. The findings appear... view more (2008-04-11)

A new focus for the mechanism of nerve growth
Researchers at Yale shed new light on the mechanism of nerve cell growth by identifying novel functions for a molecular "motor" protein, myosin-II, according to an article in the March issue of Nature Cell Biology.   view more (2006-03-20)

Telling axons where to go - and grow
In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg (Germany) describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.   view more (2005-10-03)

U of MN researchers develop mouse model for muscle disease
Researchers from the University of Minnesota have identified the importance of a gene critical to normal muscle function, resulting in a new mouse model for a poorly understood muscle disease in humans.   view more (2006-09-06)

Understanding the migration of cancer cells
Lamellipodia are veil-shaped protrusions of the plasma membrane, that can turn into upward-curled ruffles if they fail to adhere to the substrate.   view more (2008-06-23)

Structures of marine toxins provide insight into their effectiveness as cancer drugs
Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.   view more (2005-09-27)

Image of myosin-actin interaction revealed in cover story of Molecular Cell
Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model... view more (2005-09-30)

What Are Muscle Proteins Doing in the Nucleus?
The proteins actin and myosin have a firm place in the muscles where they are responsible for contraction. While recent investigations have shown that they are also found in the nucleus, it has been unclear to date just what they are doing there. Now an international team of investigators headed by... view more (2005-02-01)

Movement of chromosome in nucleus visualized
The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around.   view more (2006-04-18)

Scientists identify molecular cause for one form of deafness
Scientists exploring the physics of hearing have found an underlying molecular cause for one form of deafness, and a conceptual connection between deafness and the organization of liquid crystals, which are used in flat-panel displays.   view more (2007-02-06)

New insight into machinery of immune cells' 'tentacles'
Researchers have identified new molecular components of the machinery that regulates formation of the tentacle-like filaments by which immune system T cells grasp other cells.   view more (2006-01-10)

Screening for complex genetic interactions
In a report published online ahead of the January 15th print edition, Dr. David Amberg (SUNY Upstate Medical University) and colleagues have developed a large-scale reverse genetic screen to identify complex haploinsufficient interactions in S. cerevisiae.   view more (2006-12-28)

Genetics behind developmental brain disorders may play a wider role with congenital diseases
Findings of a recent genetic study on developmental brain disorders may be the "tip of an iceberg" revealing factors involved with a number of congenital diseases, according to UC Irvine researchers.   view more (2006-07-07)

Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
By better understanding how antimicrobials bind and thereby get inactivated in the mucus of air passages, researchers at the University of Illinois may have found a way to help cystic fibrosis patients fight off deadly infections.   view more (2007-09-25)

A stepwise retreat: how immune cells catch pathogens
To protect us from disease our immune system employs macrophages, cells that roam our body in search of disease-causing bacteria.   view more (2007-07-12)

Going Ballistic: Soft Structures Could Spell The End For Slow Shrimps
Many animals are able to rapidly extend their tongues to catch prey. In fact, the chameleon extends its tongue at an acceleration rate of 500 metres per second square - generating 5 times the G force experienced by an F-16 fighter during its most demanding maneouvre! New research presented at the... view more (2002-04-09)

How red blood cells nuke their nuclei
Unlike the rest of the cells in your body, your red blood cells lack nuclei. That quirk dates back to the time when mammals began to evolve. Other vertebrates such as fish, reptiles, and birds, have red cells that contain nuclei that are inactive. Losing the nucleus enables the red blood cell to... view more (2008-02-11)

New research sheds light on bacterial firework display
Scientists at the Institute for Animal Health have revealed how a tropical bacterium is able invade cells, and ultimately trigger its escape using a homemade rocket. Their work is published in the November issue of Molecular Microbiology. A group of scientists led by Dr Ed Galyov and Dr Mark... view more (2002-11-01)

Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.   view more (2008-06-13)

Molecular motors may speed nutrient processing
Matthew Tyska, Ph.D., recalls being intrigued, from the first day of his postdoctoral fellowship in 1999, with a nearly 30-year-old photograph. It was an electron micrograph that showed the internal structures of an intestinal cell microvillus, a finger-like protrusion on the cell surface.... view more (2007-05-31)

Spiders Help Scientists Discover How Muscles Relax
Using muscle tissue from tarantulas, an HHMI international research scholar and his colleagues have figured out the detailed structure and arrangement of the miniature molecular motors that control movement.   view more (2005-08-25)

Weizmann Institute scientists discover a key player in embryonic muscle development
Muscle fibers are large cells that contain many nuclei. They begin, like all animal cells, as naive embryonic cells. These cells differentiate, producing intermediate cells called myoblasts that are now destined to become muscle.   view more (2007-04-12)
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