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Rate of secondary cancers increases over years after treatment for childhood leukemia
Survivors of acute lymphoblastic leukemia have a significantly increased risk of secondary cancers developing over 30 years after leukemia treatment when compared to the general population. view more (2007-03-21)
Genetic Testing For Cell-Proliferation Enzyme Could Improve Treatment Of Acute Lymphoblastic Leukaemia (p 1033)
Authors of a Canadian research letter in this week's issue of THE LANCET describe how genetic testing for an enzyme involved in cancer-cell proliferation could identify patients at an increased risk of poor outcome from acute lymphoblastic leukaemia. The enzyme thymidylate synthase is associated with cell proliferation, and is therefore an... view more... (2002-03-20)
MGH study identifies first molecular steps to childhood leukemia
A Massachusetts General Hospital (MGH)-based research team has identified how a chromosomal abnormality known to be associated with acute lymphoblastic leukemia (ALL) - the most common cancer in children - initiates the disease process. view more (2009-07-16)
New genes involved in Acute Lymphoblastic Leukemia play fundamental role in prognosis of the disease
The inactivity or "silence" of certain genes plays a fundamental role in the prognosis of acute lymphoblastic leukemia (ALL) as well as in response to treatment, according to the results of research involving a team made up of specialists from the University Hospital of Navarra and the Centre for Applied Medical Research (CIMA) at the... view more... (2009-02-09)
Study identifies molecular process underlying leukemia
New research from the University of North Carolina at Chapel Hill has identified a molecular process in cells that is crucial to the development of two common leukemias. view more (2006-08-22)
The genetics of MLL leukemogenesis
In the November 1st issue of G&D, Dr. Michael Cleary (Stanford University School of Medicine) and colleagues identify the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL leukemia. view more (2007-10-17)
A new line of treatment discovered for acute lymphoblastic leucemia
A study undertaken by a group of Spanish scientists, amongst which were members of the University Clinic of the University of Navarra and the Centre for Applied Medical Research (CIMA) of the same university, have recently discovered a new line of treatment for patients with acute lymphoblastic leucemia. view more (2007-02-12)
St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
Researchers at St. Jude Childrenˇ¦s Research Hospital have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL). view more (2008-04-15)
Progress toward a targeted therapy for a specific form of leukemia
Leukemia, or cancer of the bone marrow, strikes some 700 Belgians each year. Scientists are still searching for the cause of many forms of leukemia, including T-cell acute lymphoblastic leukemia, or T-ALL. view more (2007-04-16)
Researchers find drug that inhibits acute leukemia cell growth
Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have discovered how to turn off a certain receptor that promotes the growth of leukemia cells. view more (2009-04-27)
St. Jude identifies genomic causes of a certain type of leukemia relapse
Scientists at St. Jude Children's Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. view more (2008-12-01)
Scientists link genetic glitches to common childhood cancer
A multicenter team of childhood cancer researchers has discovered two genetic variations linked to an increased risk for acute lymphoblastic leukemia, or ALL, the most common childhood cancer in the United States. view more (2009-08-18)
FOLATE SUPPLEMENTS DURING PREGNANCY COULD PROTECT AGAINST LEUKAEMIA (p 1935)
A population-based study from Western Australia in this week's issue of THE LANCET suggests that folate and iron supplementation during pregnancy might be associated with a decreased risk of childhood acute lymphoblastic leukaemia (ALL). ALL is the most common childhood cancer in more-developed countries but it has few recognised risk factors or... view more... (2001-12-05)
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning. view more (2009-11-16)
Novel drug preventing protein recycling shows potential for treating leukemia
Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found that a novel targeted therapy effectively treats acute leukemia in animal models by preventing cancer cells from being purged of damaged proteins. view more (2007-04-20)
Daisies lead scientists down path to new leukemia drug
A new, easily ingested form of a compound that has already shown it can attack the roots of leukemia in laboratory studies is moving into human clinical trials, according to a new article by University of Rochester investigators in the journal, Blood. view more (2007-10-03)
UCLA researchers identify leukemia stem cells
Stem cell researchers at UCLA have identified a type of leukemia stem cell and uncovered the molecular and genetic mechanisms that cause a normal blood stem cells to become cancerous. view more (2008-05-27)
Molecular science could further improve leukemia survival, say St. Jude researchers
The dramatic increase that has occurred in the cure rate for children with acute lymphoblastic leukemia (ALL) will be difficult to replicate in older patients without considerable additional research. view more (2008-03-24)
Developing cancer treatments directed at critical developmental pathway
Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is not universally essential for the maintenance of stem cells. view more (2008-04-11)
New treatment more than doubles survival for high risk childhood leukemia
Results of a phase two clinical trial published October 5th in the Journal of Clinical Oncology show that adding continuous daily doses of a targeted drug called imatinib mesylate to regular chemotherapy more than doubled three-year survival rates for children with a high risk type of blood cancer called Philadelphia chromosome-positive acute... view more... (2009-10-07)
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