Alpha-synuclein Current Events | Alpha-synuclein News
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A balancing act in Parkinson's disease: Phosphorylation of alpha-synuclein
Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. view more (2009-10-13)
Einstein researchers discover important clue to the cause of Parkinson's disease
A glitch in the mechanism by which cells recycle damaged components may trigger Parkinson's disease, according to a study by scientists at the Albert Einstein College of Medicine of Yeshiva University. view more (2008-01-03)
Gene therapy 'turns off' mutation linked to Parkinson's disease
A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease. view more (2006-01-19)
How the pathology of Parkinson's disease spreads
Accumulation of the synaptic protein alpha-synuclein, resulting in the formation of aggregates called Lewy bodies in the brain, is a hallmark of Parkinson's and other related neurodegenerative diseases. view more (2009-07-28)
Toxicity mechanism identified for Parkinson's disease
Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. view more (2009-01-05)
Blood-related genetic mechanisms found important in Parkinson's disease
What does the genetics of blood cells have to do with brain cells related to Parkinson's disease? From an unusual collaboration of neurologists and a pharmacologist comes the surprising answer: Genetic mechanisms at play in blood cells also control a gene and protein that cause Parkinson's disease. view more (2008-07-22)
Mice models developed at UCSD to benefit patients with multiple system atrophy
Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a series of transgenic mouse models of multiple system atrophy, a progressive, fatal neurological disorder. view more (2005-11-17)
Penn study finds way to prevent protein clumping characteristic of Parkinson's disease
Researchers at the University of Pennsylvania School of Medicine have identified a protein from a most unlikely source -- baker's yeast -- that might protect against Parkinson's disease. view more (2008-08-15)
Fine-tuning treatments for depression
New research clarifies how neurotransmitters like norepinephrine, serotonin, and dopamine, are regulated - a finding that may help fine-tune therapies for depression. view more (2009-10-19)
Out-of-whack protein may boost Parkinson's
A single change in a protein may play a role in whether someone develops Parkinson's disease, say University of Florida Genetics Institute researchers writing in a recent issue of the Proceedings of the National Academy of Sciences. view more (2008-02-27)
Disease-causing protein protects against nerve damage in Parkinson's disease
Researchers at UT Southwestern Medical Center have discovered that a protein associated with causing neurodegenerative conditions may, when appearing in normal amounts, actually protect against neurodegeneration. view more (2005-11-04)
Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape
In an Early Edition publication of The Proceedings of the National Academy of Sciences (PNAS) this week, the researchers demonstrate the "alpha-synuclein dance" - the switching back and forth of the protein between a bent helix and an extended helix as the surface that it is binding to changes. view more (2009-03-17)
Mimicking a human disease in mice: a new model for the Parkinson related illness multiple system atrophy
In this month`s issue of EMBO Reports Kahle et al. describe how they genetically engineered a mouse to show pathological symptoms similar to those of human patients suffering from the neural disease Multiple System Atrophy (MSA), also known as Shy-Drager-Syndrome. The model could help researchers to develop and test new efficient drugs against... view more... (2002-06-06)
New blood test can diagnose and monitor treatment of Parkinson's disease
While Florey researchers have also created a genetic test for PD (10% of PD cases are caused by genetic factors), this new test has a broader application by screening for many different types of PD and monitoring treatment, as well as measuring the effectiveness of drugs being developed to treat the disease. view more (2007-04-27)
How yeast is helping us to understand Parkinson's Disease
Teams of scientists from Australia and the United States have used yeast and mammalian cells to discover a connection between genetic and environmental causes of Parkinson's disease. view more (2009-02-27)
Parkinson's Disease Mechanism Discovered
Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine-producing nerve cells and ultimately symptoms of Parkinson's disease. view more (2006-06-23)
Dementia induced and blocked in Parkinson's fly model
Parkinson's disease is well-known for impairing movement and causing tremors, but many patients also develop other serious problems, including sleep disturbances and significant losses in cognitive function known as dementia. view more (2009-08-03)
Gene therapy shows promise in model of Parkinson's disease
Scientists at the Ecole Polytechnique Federale de Lausanne (EPFL) in Lausanne, Switzerland, have conducted novel experiments that might one day lead to gene therapy treatment options for patients with Parkinson's disease. In research published this week in the Proceedings of the National Academy of Sciences, the research team, led by EPFL... view more... (2004-11-24)
Calculating gene and protein connections in a Parkinson's disease model
Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect cell survival. Misfolded... view more... (2009-02-23)
Penn study finds link between Parkinson's disease genes and manganese poisoning
A connection between genetic and environmental causes of Parkinson's disease has been discovered by a research team led by Aaron D. Gitler, PhD, Assistant Professor in the Department of Cell and Developmental Biology at the University of Pennsylvania School of Medicine. view more (2009-02-02)
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