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Alzheimer's disease patients show improvement in trial of new drug
A new drug has been shown to improve the brain function of people with early stage Alzheimer's disease and reduce a key protein associated with the disease in the spinal fluid, in a small study published today in the journal Lancet Neurology and presented at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease. view more (2008-07-30)
UIC chemists characterize Alzheimer's neurotoxin structure
Amyloid plaques, the hallmark of Alzheimer's disease, are clumps of fiber-like misfolded proteins which many experts think cause this devastating neurodegenerative disease. view more (2007-12-04)
New research points toward mechanism of age-onset toxicity of Alzheimer's protein
Like most neurodegenerative diseases, Alzheimer's disease usually appears late in life, raising the question of whether it is a disastrous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to form. view more (2006-08-11)
Structure of enzyme offers treatment clues for diabetes, Alzheimer's
Researchers from the University of Chicago and Argonne National Laboratory have deciphered the three-dimensional structure of insulin-degrading enzyme, a promising target for new drugs because it breaks down not only insulin but also the amyloid-beta protein, which has been linked to the cognitive decline of Alzheimer's disease. view more (2006-10-12)
Scientists identify new strategy for preventing acute and chronic brain disease
Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that reducing levels of the protein tau can prevent seizures and neurological deficits related to Alzheimer's disease. view more (2007-05-04)
Clues to the progression of Alzheimer's disease revealed in brain imaging studies
A novel imaging agent heralded for its potential to diagnose Alzheimer's disease during life is now giving researchers information never before available about how and where the disease progresses in the brain. view more (2005-11-15)
Scientists find new genetic clue to cause of Alzheimer's disease
Variations in a gene known as SORL1 may be a factor in the development of late onset Alzheimer's disease, an international team of researchers has discovered. The genetic clue, which could lead to a better understanding of one cause of Alzheimer's, is reported in Nature Genetics online, Jan. 14, 2007, and was supported in part by the National... view more... (2007-01-15)
Researchers discover a new genetic cause of Alzheimer's disease
Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp are the first to show that the quantity of amyloid protein in brain cells is a major risk factor for Alzheimer's disease. view more (2006-04-20)
Compound in wine reduces levels of Alzheimer's disease-causing peptides
A study published in the November 11 issue of the Journal of Biological Chemistry shows that resveratrol, a compound found in grapes and red wine, lowers the levels of the amyloid-beta peptides which cause the telltale senile plaques of Alzheimer's disease. view more (2005-11-04)
Molecular imaging sheds new light on progression of Alzheimer's disease
In the past, physicians were able only to follow the progression of Alzheimer's disease (AD) through careful clinical histories, noting the often subtle changes associated with cognitive decline over a number of years. view more (2008-06-17)
High-dose Interferon Beta-1B On Alternate Days Could Offer Increased Clinical Benefit For People With Multiple Sclerosis (p 1453)
A study published in this week's issue of THE LANCET suggests that high-dose interferon beta-1b administered every other day is more effective than interferon beta-1a once a week for people with multiple sclerosis (MS). There are three interferon beta therapies known to be effective in reducing MS symptoms: interferon beta-1a 30 mcg administered... view more... (2002-04-24)
Yeast model shows promise as Alzheimer's test
A century ago this month, German psychiatrist Alois Alzheimer formally described characteristics of the neurodegenerative disease which ultimately came to bear his name. view more (2006-11-20)
Common epilepsy drug could prevent and treat Alzheimer's disease
The team led by UBC Psychiatry Prof. Weihong Song, who is also the Jack Brown and Family Professor and Chair in Alzheimer's Disease at UBC, found that if Valproic Acid (VPA) is used as a treatment in early stages of AD memory deficit is reversed. view more (2008-10-27)
The Lancet Neurology November Issue Press Release
NO SEX PLEASE, WE`RE BRITISH (NEUROLOGISTS) It is well known in media circles that including the word "sex" in a headline is a sure-fire way of attracting the attention of potential readers. It is understandable, therefore, why a paper published in the Journal of Neurology, Neurosurgery, and Psychiatry (JNNP) entitled "Is multiple... view more... (2002-10-16)
Altering brain's lipid metabolism reduces Alzheimer's plaques in mice
Increasing levels of a protein that helps the brain use cholesterol may slow the development of Alzheimer's disease changes in the brain. view more (2008-01-18)
Tumors stopped from spreading to new sites
For several types of cancer, persistently high levels of the soluble factor TGF-beta in the blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis and a poor prognosis. view more (2007-04-06)
A high-fat diet could promote the development of Alzheimer's
A team of Université Laval researchers has shown that the main neurological markers for Alzheimer's disease are exacerbated in the brains of mice fed a diet rich in animal fat and poor in omega-3s. view more (2008-10-29)
Testosterone therapy may prevent Alzheimer's disease
Researchers at the University of Southern California have discovered a direct link between loss of testosterone and the development of an Alzheimer's-like disease in mice. They also discovered that testosterone treatment slows progression of the disease. view more (2006-12-20)
A Novel Strategy for Combating Aids-Related Fungal Infections
Research at the Sir William Dunn School of Pathology has identified Dectin-1 as the beta-glucan receptor on immune cells. This finding may be of use in the prophylactic prevention of a variety of infections, especially in surgical patients, and in the treatment of cancer. The identification of Dectin-1 as the beta-glucan receptor may also provide... view more... (2004-10-08)
Manipulating Brain Inflammation May Help Clear Brain of Amyloid Plaques, Mayo Clinic Researchers Say
In a surprising reversal of long-standing scientific belief, researchers at the Mayo Clinic campus in Florida have discovered that inflammation in the brain is not the trigger that leads to buildup of amyloid deposits and development of Alzheimer's disease. view more (2009-10-23)
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