Amyotrophic Lateral Sclerosis Current Events | Amyotrophic Lateral Sclerosis News | 3
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Genes influence both susceptibility to, and progression of, multiple sclerosis
Susceptibility to multiple sclerosis (MS), and the way in which the disease progresses, are genetically determined, suggests research in the Journal of Neurology Neurosurgery and Psychiatry. view more (2001-11-23)
Further evidence showing treatment benefits of beta interferon for multiple sclerosis (pp 1463, 1489)
Results of a European study in this week's issue of THE LANCET provide further evidence that patients with early symptoms of multiple sclerosis given a weekly injection with interferon beta are less likely to progress to full clinical disease after two years follow-up. The study showed that the drug reduced patients' loss of brain tissue compared... view more... (2004-10-20)
Thinking about moving? Let brain waves do the walking
Using brain waves to control screen cursor movements, rather than moving a mouse by hand, seems like science fiction! Yet such direct control over our environment is an integral part of the development work being undertaken by participants in the Presencia project. view more (2004-12-02)
Detection Of Antibodies Could Identify MS Patients Who Do Not Respond Well To Interferon Beta (P1184)
Danish research published in this week's issue of THE LANCET highlights how the detection of antibodies to interferon beta-the first choice treatment for multiple sclerosis patients-could be important in identifying patients who do not respond well to interferon beta, with implications for the provision of alternative drug therapy. Interferon beta... view more... (2003-10-08)
Cognitive impairment appears to be common in ALS patients
In a study of 40 patients with amyotrophic lateral sclerosis (ALS), about one-third showed evidence of cognitive impairment, but these deficits did not appear to be related to survival. view more (2006-03-14)
UCLA stem cells scientists make electrically active motor neurons from iPS cells
Stem cells scientists at UCLA showed for the first time that human induced pluripotent stem (iPS) cells can be differentiated into electrically active motor neurons, a discovery that may aid in studying and treating neurological disorders. view more (2009-02-25)
Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
A Mayo Clinic-led international consortium has found a mechanism that may help explain Parkinson's and other neurological disorders. view more (2009-01-12)
Study uses MRI to determine features of osteoarthrosis
Abnormalities in the ligaments found on the outside of the knee (lateral collateral ligament complex or LCLC) are commonly seen on MRI in patients with knee osteoarthrosis (OA). view more (2007-05-07)
Researchers genetically link Lou Gehrig's disease in humans to dog disease
An incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs. Researchers from the University of Missouri and the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic lateral sclerosis (ALS), the human disease also... view more... (2009-01-22)
Majority of children vaccinated against hepatitis B not at increased risk of MS
The majority of children vaccinated against hepatitis B are not at an increased risk of developing multiple sclerosis (MS). view more (2008-09-26)
Treating MS is expensive, but cost falls over time
The cost of drug treatment multiple sclerosis is high, but decreases with prolonged treatment up to 20 years, concludes a study in this week's BMJ. Researchers evaluated the cost effectiveness of four drugs currently licensed for the treatment of multiple sclerosis in the United Kingdom (three interferon betas and glatiramer acetate). They... view more... (2003-03-05)
Inauguration of the 1st International Conference on Rare Diseases and Orphan Drugs
"The development of orphan drugs for treating rare diseases is completely dependent on an active interaction between academic research and industry," says Jan Carlstedt-Duke, dean of research at Karolinska Institutet. view more (2005-02-15)
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease. view more (2008-06-17)
Genetic breakthrough offers promise in tackling kidney tumors
A new study has shown promising results in fighting a severe genetic disorder which can create tumours throughout the body. view more (2008-01-11)
Researchers develop marker that identifies energy-producing centers in nerve cells
A protein that causes coral to glow is helping researchers at the University of Maryland School of Medicine to light up brain cells that are critical for the proper functioning of the central nervous system. view more (2007-02-02)
Test reveals effectiveness of potential Huntington's disease drugs
A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds - memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report. view more (2006-10-30)
Test reveals effectiveness of potential Huntington's disease drugs
A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds-memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report. view more (2006-10-31)
Neurotransmitter orexin associated with pleasure and reward pathways in the brain
Researchers at the University of Pennsylvania School of Medicine have discovered that the recently identified neurotransmitter orexin (also known as hypocretin) influences reward processing by activating neurons in the lateral hypothalamus region of the brain. view more (2005-08-26)
More genes for Lou Gehrig's disease identified, according to Penn researchers
In recent months a spate of mutations have been found in a disease protein called TDP-43 that is implicated in two neurodegenerative disorders: amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, and certain types of frontotemporal dementia (FTD). These mutations could potentially become candidates for drug targets. view more (2008-04-08)
Variations in detoxifying genes linked to Lou Gehrig's disease
Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold increased risk of ALS in Gulf War veterans. view more (2006-07-06)
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