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Amyotrophic Lateral Sclerosis Current Events | Amyotrophic Lateral Sclerosis News | 5

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From a lowly yeast, researchers divine a clue to human disease
Working with a common form of brewer's yeast, University of Wisconsin-Madison researchers have uncovered novel functions of a key protein that allow it to act as a master regulatory switch - a control that determines gene activity and that, when malfunctioning in humans, may contribute to serious neurological disorders.   view more (2006-12-08)

Understanding a target of quinoline drugs
The full details about the molecules and mechanisms that underlie the development of autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, remain to be discovered.   view more (2009-04-28)

Mayo Clinic study unveils unprecedented method to predict ALS, Parkinson's disease
A new Mayo Clinic study details an unprecedented method to predict brain aging disorders such as amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) and Parkinson's disease.   view more (2008-01-16)

Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
A group of Israeli scientists from the Technion - Israel Institute of Technology, the Weizmann Institute of Science and Teva Pharmaceutical Industries have recently identified genes responsible for the positive response of many multiple sclerosis patients to the drug Copaxone.   view more (2007-10-11)

Targeting astrocytes slows disease progression in ALS
In what the researchers say could be promising news in the quest to find a therapy to slow the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, scientists at the University of California, San Diego (UCSD) School of Medicine have shown that targeting neuronal support cells called astrocytes sharply slows disease... view more... (2008-02-04)

A clue to core problem of neurodegenerative disease and cell death
Misfolded and damaged proteins are common to all human neurodegenerative diseases. Clumps of these aggregated proteins destroy neurons within the brain and cause disease.   view more (2006-02-10)

Human stem cells delay start of Lou Gehrig's disease in rats
Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life.   view more (2006-10-16)

Fitness in a Changing World
The stickleback fish, Gasterosteus aculeatus, is one of the most thoroughly studied organisms in the wild, and has been a particularly useful model for understanding variation in physiology, behavior, life history and morphology caused by different ecological situations in the wild.   view more (2008-10-13)

Factors from common human bacteria may trigger multiple sclerosis
Current research suggests that a common oral bacterium may exacerbate autoimmune disease. The related report by Nichols et al, "Unique Lipids from a Common Human Bacterium Represent a New Class of TLR2 Ligands Capable of Enhancing Autoimmunity," appears in the December 2009 issue of The American Journal of Pathology.   view more (2009-11-24)

The Lancet Neurology - January 2003
STROKE IN THE 21st CENTURY In the first issue of 2003, TLN examines stroke epidemiology and stroke trials. In their review, Valery Feigin and co-authors provide an overview of population-based studies of incidence, prevalence, mortality, and case-fatality of stroke based on studies reported between 1996 and 2002. From their analysis the authors... view more... (2002-12-18)

Brain-computer link allows paralyzed patient to manipulate devices by thought
A patient with a spinal cord injury was able to produce brain signals associated with intending to move his paralyzed limbs, signals picked up by an implanted sensor and translated into electronic impulses that allowed him to control a computer cursor and manipulate mechanical devices.   view more (2006-07-13)

Data mining detects signs of Lou Gehrig's disease in gene carriers long before symptoms appear
Inspired by the use of microarray chips that look for gene combinations, psychologists are using "pattern array" software to spot movements in rats that might help them predict diseases such as Lou Gehrig's syndrome.   view more (2008-08-04)

Study links Alzheimer's disease to abnormal cell division
A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.   view more (2006-01-18)

Evolution mystery: Spider venom and bacteria share same toxin
Biology researchers at Lewis & Clark College and the University of Arizona have found evidence for an ancient transfer of a toxin between ancestors of two very dissimilar organisms-spiders and a bacterium.   view more (2006-02-02)

Multiple sclerosis research charges ahead with new mouse model of disease
A new study highlights the role of a charge-switching enzyme in nervous system deficits characteristic of multiple sclerosis and other related neurological illness.   view more (2008-11-06)

Growth factor stimulates rapid extension of key motor neurons in brain
A growth factor known to be important for the survival of many types of cells stimulates rapid extension of corticospinal motor neurons - critical brain cells that connect the cerebral cortex with the spinal cord and that die in motor neuron diseases like amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).   view more (2006-11-06)

Mechanism related to the onset of various genetic diseases revealed
Researchers at the Department of Biochemistry and Molecular Biology of Universitat Autònoma de Barcelona (UAB) have revealed the process by which proteins with a tendency to cause conformational diseases such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc. finally end up... view more... (2009-09-18)

Patients taking Tysabri report improvement in physical and psychological well-being over time
Biogen Idec (NASDAQ: BIIB) and Elan Corporation, plc (NYSE: ELN) today announced six-month results of an ongoing, one-year longitudinal, observational, patient-reported outcomes study showing multiple sclerosis (MS) patients taking TYSABRI® (natalizumab) experienced an improvement in both their physical function and psychological well-being.   view more (2009-09-11)

Major breakthrough in the mechanism of myelin formation
The group of Dr. Michel Cayouette, researcher at Institut de recherches cliniques de Montréal (IRCM), and Dr. Jonah Chan, collaborator at the University of Southern California, will publish in the next issue of the prestigious scientific journal Science, the results of their study that could have a major impact on the treatment of diseases... view more... (2006-11-03)

First new multiple sclerosis gene found in 30 years
A newly identified gene may hold the promise of guiding future research into therapies for multiple sclerosis in what its discoverers say is the first major genetic advance in 30 years for understanding this nervous system disease.   view more (2007-07-30)
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