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Increased antidepressant prescribing linked with fewer suicides
In Australia, suicide rates have fallen most in those groups of people most exposed to antidepressant drugs, especially older people.   view more (2003-05-07)

When antidepressant drugs stop working: A novel approach
Tolerance to antidepressant drug treatment is an important clinical problem (one third of cases). It may manifest as loss of clinical effect (an antidepressant drug which was working stops doing so) or resistance (a patient, after a drug-free period, fails to respond to an antidepressant drug which was effective before). There is no current... view more... (2003-05-06)

Can Long-term Treatment With Antidepressant Drugs Worsen The Course Of Depression?
The Journal of Clinical Psychiatry releases a review by Giovanni A. Fava (University of Bologna) which is likely to stir a lot controversy and be disliked by the Big Pharma. The possibility that antidepressant drugs, while effectively treating depression, may worsen its course has received inadequate attention. A review of the literature,... view more... (2003-03-17)

Treating SSRI-Resistant Depression
When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action? This is the question asked by researchers in a new report scheduled for publication in Biological Psychiatry on April 1st.   view more (2008-03-26)

No link between antidepressants and birth defects
Expectant mothers can safely use prescribed antidepressants during their first trimester, according to a new study from the Université de Montréal and Ste. Justine Hospital published in the May edition of the British Journal of Psychiatry.   view more (2008-05-23)

Costs of antidepressants could have funded effective alternatives
Some of the costs of prescribing antidepressant drugs over the last decade could have been used to deliver psychological treatments of proven effectiveness, finds a study published online by the BMJ today.   view more (2005-03-16)

Women with major depression at risk of relapse during pregnancy
Contrary to a common belief that the hormonal changes associated with pregnancy provide a protective effect against depression, women with major depression who discontinue antidepressant medication during pregnancy are at risk of relapse.   view more (2006-02-01)

Researchers explore the antidepressant effects of ketamine
Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly.   view more (2008-02-22)

Potential candidate chemical for antidepressant effects of exercise found
The antidepressant effects of exercise may be down to a chemical called phenylethylamine, reports a pilot study in the British Journal of Sports Medicine. Although research suggests that exercise is an effective antidepressant, exactly how it works has not been clear. The study focused on 20 healthy young men, average age 22. The young men did... view more... (2001-09-26)

FDA warnings affected prescriptions of antidepressants to youth
U.S. Food and Drug Administration warnings regarding the risk of suicidal thoughts and behaviors in children and adolescents taking antidepressants appear to have had modest and targeted effects on the intended populations.   view more (2008-01-08)

Regular follow-up important during antidepressant treatment
Because individuals can react differently to antidepressant medications, regular follow-up is important during the first few weeks of treatment, according to an editorial by Group Health psychiatrist and researcher Greg Simon, MD, MPH.   view more (2006-11-01)

Suicide risk does not increase when adults start using antidepressants, study finds
The risk of serious suicide attempts or death by suicide generally decreases in the weeks after patients start taking antidepressant medication.   view more (2006-01-03)

Potential new targets for antidepressant medications
The news about antidepressant medications over the past several years has been mixed. The bad news from large multicenter studies such as STAR*D is that current antidepressant medications are effective, but not as effective as one might hope. Thus, there is a significant need for new treatment mechanisms for depression.   view more (2008-08-27)

Inflammation, depression and antidepressant response: Common mechanisms
Major depressive disorder is a common and complex condition that impacts about 15% of the population of the United States, yet very little is known about the mechanisms behind the psychiatric disorder.   view more (2008-05-30)

Ketamine reduces suicidality in depressed patients
Drug treatment options for depression can take weeks for the beneficial effects to emerge, which is clearly inadequate for those at immediate risk of suicide.   view more (2009-09-10)

Children and teens taking antidepressants might be more likely to attempt, complete suicide
Antidepressant medications may be associated with suicide attempts and death in severely depressed children and adolescents but not in adults.   view more (2006-08-08)

Popular antidepressant associated with a dramatic increase in suicidal thoughts amongst men
Nortriptyline has been found to cause a ten-fold increase in suicidal thoughts in men when compared to its competitor escitalopram. These findings are published in the open access journal BMC Medicine.    view more (2009-10-15)

Effectiveness of certain antidepressants may be influenced by gene variations of individuals
Whether specific types of antidepressants are effective for patients with late-life major depression may depend if they have certain genetic variations.   view more (2006-10-04)

Possible genetic predictor for response to lithium augmentation in depressed patients
As in most fields of medicine, psychiatry researchers are working to identify specific types of patients, through their individual genetic variations, that may better benefit from particular drugs or combinations of drugs than other patients.   view more (2007-12-07)

When physical and mental health problems co-occur and money gets tight, which prescriptions go unfilled?
A new study points to a troubling connection between out-of-pocket expenses for people contending with both physical illnesses and depression, affecting access to antidepressant treatment.   view more (2009-04-08)
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