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Action needed to avoid HIV drug resistance in Africa
We should stop and think about the risks of resistance, and ways of minimising them, before increasing access to antiretroviral therapy in Africa, argue researchers in this week's BMJ. view more (2004-01-29)
ADVERSE EFFECTS OF ANTIRETROVIRAL TREATMENT FOR HIV INFECTION (p1320)
It is well known that treatment of HIV-1 infection (that may lead to AIDS) has side effects, but there are few studies of how many people having treatment are affected by adverse reactions. In a study of 1160 people receiving antiretroviral treatment, published in The Lancet this week, Jacques Fallon and colleagues from the Swiss HIV Cohort Study... view more... (2001-10-17)
EARLY ASSESSMENT PREDICTS LONG-TERM EFFICACY OF HIV-1 ANTIRETROVIRAL THERAPY (p 1760)
A study in this week's issue of THE LANCET highlights how very early (one week) assessment can reliably predict the long-term effectiveness of antiretroviral therapy for HIV-1. Early assessment of antiretroviral drug efficacy is important for the prevention of the emergence of drug-resistant virus and unnecessary exposure to ineffective and toxic... view more... (2001-11-21)
LIPODYSTROPHY RISK FROM HIV-1 THERAPY (p 592)
The risk of lipodystrophy (abnormal fat distribution) in HIV-1 individuals undergoing antiretroviral therapy cannot be attributed to one antiretroviral agent, conclude authors of a study in this week's issue of THE LANCET. Lipodystrophy among HIV-1-infected patients receiving antiretroviral therapy was formally described as a clinical entity in... view more... (2001-02-21)
Ethnic differences in response to HIV medicines
Researchers from the University of Massachusetts and the University of Pennsylvania have shown that race/ethnicity is a predictor of plasma lipids in patients with HIV-1 on HAART (highly active antiretroviral therapy). view more (2006-01-24)
Successful Implementation Of Pilot Study For Hiv Antiretroviral Therapy In Uganda (p 34)
Authors of a study in this week's issue of THE LANCET report on the successful implementation of a UNAIDS/Uganda Health Ministry initiative to provide antiretroviral treatment to people with HIV/AIDS in Uganda. Little is known about how to implement complex HIV-1 treatment programmes in resource-limited countries. Paul Weidle from the Centers for... view more... (2002-07-03)
Certain HIV treatment less effective when used with anti-TB therapy
Patients receiving rifampicin-based anti-tuberculosis therapy are more likely to experience virological failure when starting nevirapine-based antiretroviral therapy, an HIV treatment that is widely used in developing countries because of lower cost, than when starting efavirenz-based antiretroviral therapy. view more (2008-08-04)
Has HIV Become More Virulent?
Damage to patients' immune systems is happening sooner now than it did at the beginning of the HIV epidemic, suggesting the virus has become more virulent. view more (2009-04-08)
Women with AIDS face cervical cancer threat
According to a report issued last week by UNAIDS, access to antiretroviral therapy is beginning to reduce AIDS mortality worldwide. view more (2007-12-03)
Sustained Reduction In AIDS Since Introduction Of Highly Active Antiretroviral Therapy (p 22)
European research in this week's issue of THE LANCET highlights how the introduction of highly active antiretroviral therapy has had a sustained effect in reducing illness and death from HIV/AIDS over the past few years. Highly active antiretroviral therapy was introduced around 1996 and immediately brought about a substantial reduction in illness... view more... (2003-07-02)
Human testis harbors HIV-1 in resident immune cells
Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. view more (2006-11-27)
New Study Shows Benefit of Early Therapy in HIV-infected Infants
Antiretroviral therapy (ART) for infants born with HIV infection may be most effective when given in their first five months of life, according to a study published in the April 1 issue of The Journal of Infectious Diseases, now available online. view more (2006-03-09)
Study finds major interruptions in antiretroviral therapy after release from prison
The vast majority of HIV-infected Texas prison inmates who receive antiretroviral therapy while incarcerated experience significant interruptions in HIV treatment after their release into the community. view more (2009-02-25)
HIV persists in the gut despite long-term HIV therapy
Even with effective anti-HIV therapies, doctors still have not been able to eradicate the virus from infected individuals who are receiving such treatments, largely because of the persistence of HIV in hideouts known as viral reservoirs. view more (2008-02-14)
Increasing access to antiretroviral drugs would drastically cut AIDS deaths in South Africa
More that 1.2 million deaths could be prevented in South Africa over the next five years by accelerating efforts to provide access to antiretroviral therapy (ART), according to a study released online today by the Journal of Infectious Diseases. view more (2008-03-27)
Long-term HIV treatment may reduce risk for atherosclerosis
Antiretroviral drugs for HIV do not increase the risk for coronary atherosclerosis, a central risk factor for heart disease, according to a study led by the University of Pittsburgh Graduate School of Public Health to be published in the Aug. 8 issue of the journal AIDS and available online today. view more (2008-08-05)
New treatment model for HIV
Treatment of HIV patients must balance the need to suppress viral replication against the harmful side effects and significant cost to the patient of antiretroviral therapy. view more (2007-07-13)
Study finds limited options for backup HIV treatment in some developing countries
Thai researchers have discovered that patients who fail treatment with a commonly used, inexpensive, first-line antiretroviral therapy (ART) are also usually resistant to other, similar drugs, leaving progressively fewer options for replacement therapies. view more (2007-01-09)
Study finds limited options for backup HIV treatment in some developing countries
Thai researchers have discovered that patients who fail treatment with a commonly used, inexpensive, first-line antiretroviral therapy (ART) are also usually resistant to other, similar drugs, leaving progressively fewer options for replacement therapies. view more (2007-01-09)
New Approaches To HIV Treatment In Less-developed Countries (pp 404, 410)
Two Viewpoint articles in this week's issue of THE LANCET highlight how the use of highly-active antiretroviral therapy (HAART) for HIV-1 treatment - currently only widely available in industrialised countries - could become accessible in less-developed settings. Both articles suggest new strategies for implementing HAART using infrastructure... view more... (2001-08-01)
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