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Tumor cells evade death through autophagy
Autophagy is a cellular process that enables cells to turnover their contents, something that they do frequently. Autophagy is initiated in tumor cells by chemotherapy and radiation, but it is not known if this contributes to tumor cell death or helps tumor cells survive the anti-cancer therapy.   view more (2007-01-19)

Proteins are key to cell death in heart disease, stroke and degenerative conditions
Researchers at Yale School of Medicine have gained deeper understanding of two members of a family of proteins called caspases that play a key role in promoting apoptosis, a process in which the cell responds to external signals by essentially committing suicide.   view more (2006-02-23)

UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer.   view more (2005-11-16)

Key event in cell death occurs as single, quick event
Scientists at St. Jude Children's Research Hospital have demonstrated that a key event during apoptosis (cell suicide) occurs as a single, quick event, rather than as a step-by-step process.   view more (2006-08-02)

Refusal of suicide order: Why tumor cells become resistant
Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread throughout the body.   view more (2008-06-24)

First report that apoptotic and anti-angiogenic therapies work better together than alone
American researchers have found that giving a combination of imantanib (Glivec) and a drug that induces cell death (apoptosis) was better at inhibiting the growth of Ewing's sarcoma in mice than either therapy on its own.   view more (2006-11-13)

New insight into the genetics of brain tumor formation
In a G&D paper published online ahead of its April 1 print publication date, Dr. William Kaelin (Dana Farber Cancer Institute) and colleagues identify a potential new neuronal tumor suppressor.   view more (2008-03-18)

NEW TECHNIQUE SHOWS DEATH OF HEART CELLS IN HEART-ATTACK PATIENTS (P 209)
In this week's issue of THE LANCET, researchers from the Netherlands describe a new imaging technique capable of pinpointing areas of cell death in the hearts of patients who have had an acute myocardial infarction (heart attack). In acute myocardial infarction, the blood supply to part of the... view more (2000-07-12)

Large dose dexamethasone plays important roles in severe acute pancreatitis
Severe acute pancreatitis (SAP) is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 - 30% mortality, mainly due to multiple organ failure at its early stage.   view more (2007-11-05)

Popular herbal supplement hinders the growth of pancreatic cancer cells
A new study from the University of Pittsburgh Cancer Institute suggests that a commonly used herbal supplement, triphala, has cancer-fighting properties that prevent or slow the growth of pancreatic cancer tumors implanted in mice.   view more (2007-04-18)

Synthetic molecules hold promise for new family of anti-cancer drugs
Synthetic molecules designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.   view more (2008-06-05)

Key study offers hope to patients with lung and joint disease
People who suffer from inflammatory conditions such as chronic diseases of the lung, joints and other organs could benefit from a new discovery by scientists at the University of Edinburgh.   view more (2006-09-05)

Scythe balances life and death during development
A protein called Scythe determines which cells live and which die during the growth and development of the mammalian embryo, according to investigators at St. Jude Children's Research Hospital.   view more (2005-12-13)

University of Minnesota researchers take new look at cellular suicide
Like a bodyguard turned traitor, a protein whose regular job is to help repair severed DNA molecules will, in some cases, join forces with another protein to do the opposite and chop the DNA to bits.   view more (2006-07-07)

St. Jude researchers find key step in programmed cell death
Investigators at St. Jude Children's Research Hospital have discovered a dance of proteins that protects certain cells from undergoing apoptosis, also known as programmed cell death. Understanding the fine points of apoptosis is important to researchers seeking ways to control this process.   view more (2008-03-03)

Researchers say estrogen can kill breast cancer cells once fueled by the hormone
Fox Chase Cancer Center researchers say some breast cancer cells once fueled by estrogen can be killed by the same hormone.   view more (2005-12-07)

European Jeanne Loubaresse - Institut Curie Prize 2003 : Patrick Mehlen wins prize for his discovery of an original concept in apoptosis: dependence receptors
The European Jeanne Loubaresse-Institut Curie Prize for 2003 will be presented on 30 November 2004 at the Institut Curie by Professor Nicole Le Douarin, Permanent Secretary of the Académie des Sciences. The winner is Patrick Mehlen, CNRS Director of Research at the Léon-Bérard... view more (2004-12-02)

Researchers break chain of biochemical events that brain cancer cells use to evade therapy
In their quest to find and exploit vulnerabilities in the natural armor that protects malignant brain tumors from destruction, researchers have found a way to decrease the cells resistance to therapies that are designed to trigger cell death.   view more (2006-02-06)

Elevated testosterone kills nerve cells
A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells.   view more (2006-09-27)

New genetic association with schizophrenia found by researchers
Schizophrenia emerges from an altered pattern of brain development, and researchers continue to search for the genes that cause the brain to develop along a path that ultimately leads to schizophrenia.   view more (2008-02-29)

Hopes of a New Treatment Approach for Paralysis
Scientists at the Deutsches Krebsforschungszentrum (German Cancer Research Center, Heidelberg) were recently able to show in experiments with mice that a paralysis can be reversed by blocking programmed cell death. Paralysis in the form of paraplegia and quadriplegia is usually the result of... view more (2004-03-15)

A new chemotherapeutic target for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation.   view more (2007-10-25)

New test can identify patients who may suffer serious late toxicity from radiotherapy
Radiotherapists in Switzerland have developed a fast test that can be used immediately on patients to discover whether they are likely to suffer serious late onset side effects from radiation.   view more (2003-09-20)

Novel structure proteins could play a role in apoptosis
Isoforms from Novel Structure Proteins (NSP), a new family of genes discovered by researchers in the Sbarro Institute for Cancer Research and Molecular Medicine in Temple University's College of Science and Technology, could be involved in apoptosis or programmed cell death.   view more (2008-07-25)

Researchers find molecular 'brake' to cell death
Researchers at The University of Texas M. D. Anderson Cancer Center have significantly refined the scientific understanding of how a cell begins the process of self-destruction—an advance they say may help in the design of more targeted cancer therapies.   view more (2006-06-30)

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