Apoptosis Current Events | Apoptosis News | 6
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Stopping unwanted cell death: Implications for drug discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. view more (2008-04-14)
International Ludwig Institute for Cancer Research announces new branch director in London
The Ludwig Institute for Cancer Research (LICR) has appointed Professor Xin Lu as the new Director of the University College London (UCL) Branch of the LICR. The LICR has ten Branches around the world, each comprised of groups conducting cancer research as part of international thematic programs in the disciplines of genetics, biochemistry, cell... view more... (2004-10-18)
New path from estrogen to survival in breast cancer cells described
After years of research, scientists at The University of Texas M. D. Anderson Cancer Center are now able to explain, in exquisite molecular detail, how the estrogen hormone can help keep breast cancer cells alive. view more (2006-09-26)
Hodgkin lymphoma -- new characteristics discovered
Researchers are still discovering new characteristics of Hodgkin lymphoma, a common form of cancer of the lymphatic system. The malignant cells are derived from white blood cells (B cells), but have lost a considerable part of the B cell-specific gene expression pattern. view more (2008-10-09)
New biomarker test could predict outcome for bladder cancer patients
A set of molecular biomarkers might better predict the recurrence of bladder cancer than conventional prognostic features such as the stage or grade of the malignancy at the time it is discovered, UT Southwestern Medical Center researchers have found. view more (2007-02-02)
Drug attacks prostate cancer in mouse model by destroying its blood supply
A medication used to treat other types of cancer strangles drug-resistant, metastatic prostate cancer by cutting off its blood supply. view more (2006-06-07)
New compound 'highly efficacious' at reducing human tumour growth
Innsbruck, Austria: Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr Gerhard Siemeister of Schering AG, Corporate Research, Berlin speaking at the 18th meeting of the European Association of Cancer... view more... (2004-07-06)
U-M study offers new perspective on nitric oxide signaling in rheumatoid arthritis
Scientists at the University of Michigan Medical School have found evidence that challenges current thinking about the cause of rheumatoid arthritis (RA), a chronic inflammatory disease that damages joints, causes pain, loss of movement, and bone deformities in 2.1 million Americans. view more (2006-10-31)
A potential approach to treatment of hepatitis B virus infection
Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. view more (2008-09-10)
MicroRNA undermines tumor suppression
Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53, While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of... view more... (2009-03-18)
Cardiac cell transplant studies show promise in cardiac tissue repair
Two studies published in the current issue of CELL TRANSPLANTATION (17:6) examine the efficacy of transplanting bone marrow cells (BMCs) for the repair of heart tissue. view more (2008-09-04)
New aging studies improving vaccine efficacy for the elderly
A new study from the Trudeau Institute in Saranac Lake, New York, demonstrates that immune system cells important for both pathogen resistance and vaccine efficacy live longer in older animals but because of this longevity acquire functional defects. view more (2009-10-06)
Dual gene therapy suppresses lung cancer in preclinical test
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice. view more (2007-01-15)
Statin plus cancer drug deliver combo punch to brain cancer cells
Building on newly discovered genetic threads in the rich tapestry of biochemical signals that cause cancer, a Johns Hopkins Kimmel Cancer Center team has dramatically killed brain cancer cells by blocking those signals with a statin and an experimental antitumor drug. view more (2007-01-19)
US researchers show cottonseed drug is cancer treatment booster - patient trials now planned
New research has opened up the prospect that gossypol - a drug refined from cottonseed oil and previously tried and abandoned as a male contraceptive - could boost the effectiveness of treatment for prostate tumours and possibly other common cancers as well. view more (2004-09-29)
Novel light-sensitive compounds show promise for cancer therapy
Chemists at the University of California, Santa Cruz, have developed novel compounds that show promise for photodynamic cancer therapy, which uses light-activated drugs to kill tumor cells. view more (2009-06-17)
Roles of S100A2 and p63 in the carcinogenesis of esophageal squamous cell carcinoma
As a member of the S100 family, S100A2 is considered a candidate tumor-suppressor gene. Recently, p63 gene, a new member of the p53 gene family, has been studied in the fields of tumorigenesis, cell apoptosis and tissue growth. view more (2009-09-17)
Impaired gene helps nonsmall-cell lung cancer resist drug
Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease. view more (2006-10-02)
Mounting evidence shows red wine antioxidant kills cancer
Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function. The study is published in the March edition of the journal, Advances in Experimental Medicine and Biology. view more (2008-03-26)
Ewing's sarcoma : Discovery of a "link" in tumor growth
To develop new therapeutic approaches to cancer, it is essential to understand the long and extremely complex process that underlies it, in other words the various stages of cancer development from the initial mutation to the tumor. Having already identified the alteration that leads to Ewing's sarcoma, a bone cancer which afflicts young people,... view more... (2004-09-23)
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