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Sphingolipids with therapeutic ends
Sphingolipids have been known for more than 120 years but, up to recently, they were thought to be molecules that simply complied with a structural function, acting, as it were, as the building blocks of the biological membranes. view more (2007-03-05)
Lack of a key enzyme dramatically increases resistance to sepsis
According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. view more (2006-04-24)
Cancer: Another step towards medication
The gene Myc is an important factor for the growth of organisms by cell division. It causes the production of a protein which, as a transcription factor, controls the expression of up to 15 % of all human genes. view more (2009-03-18)
Why don't all moles progress to melanoma?
Everyone has moles. Most of the time, they are nothing but a cosmetic nuisance. But sometimes pigment-producing cells in moles called melanocytes start dividing abnormally to form a deadly form of skin cancer called melanoma. view more (2006-10-03)
What is the pathogenesis of liver damage induced by ethanol?
They investigated the effects of ethanol on the IGF-I system with the involvement of JNK1/2 activity and ADH by using each chemical inhibitor in primary cultured rat hepatocytes. The results indicate that ethanol inducedp-JNK1/2 activation is associated with the IGF-I system and cell viability in hepatocytes. view more (2008-10-08)
Jefferson Orthopaedic Surgeons Leading International Study of Timing of Spinal Surgery
When it comes to a devastating spinal injury, says spine surgeon Alexander Vaccaro, M.D., timing might be nearly everything. It's also a topic of great debate and discussion among orthopaedic surgeons. view more (2006-10-05)
A glimmer of hope in the struggle against neurodegenerative diseases: the virtues of proteins that can save dying neurons
Diseases characterized by neurodegeneration affect individuals over 50 years of age and they attack one particular class of neurons in the brain or spinal cord. The research interest of Professor Ann Kato and her team is principally focalized on ALS in which there is a progressive paralysis caused by the destruction of motor neurons which exist in... view more... (2002-01-25)
An effective target of biological therapy for hepatocellular carcinoma
It has been shown that constitutively activated STAT3 is detected in many HCC cell lines and tissues. This suggests that STAT3 is a promising molecular target for HCC gene therapy. view more (2009-06-15)
Chemopreventive agents in black raspberries identified
A study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, identifies components of black raspberries with chemopreventive potential. view more (2009-01-08)
Colon Cancer : An alternative pathway of tumor development
Cancer develops from a single damaged cell subsequent to an accumulation of genetic errors in a number of its genes. The nature of these alterations and the order in which they occur differ from one cancer to another : hence, the "pathways" that may lead to cancer are numerous. CNRS and INSERM researchers at the Institut Curie have just... view more... (2002-09-13)
St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development. view more (2007-10-19)
Study supports DNA repair-blocker research in cancer therapy
Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves. view more (2009-08-18)
A new therapeutic option for human hepatocyte cancer
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections. view more (2008-09-24)
SARS - the first comprehensive description of the damage caused by the virus
Research News in the Journal of Pathology Doctors working near to the first outbreak of severe acute respiratory syndrome (SARS) Guangdong, China, have just published the first histopathological description of the effects of this viral infection in the Journal of Pathology. Basing their findings on autopsies of three people who died of SARS, Dr... view more... (2003-06-30)
A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value. view more (2008-05-21)
A promising new approach to cadmium induced hepatoxicity: Cytoprotective effect of midkine
Cadmium comes from a wide variety of sources in the environment and from industry and is extremely toxic to humans. Environmental exposure can occur via the diet and drinking water. view more (2008-01-17)
Mechanism identified for promising neurological drug
Researchers at the San Francisco VA Medical Center have identified the mechanism by which minocycline, a medication currently being studied for the treatment of neurodegenerative diseases including Parkinson's disease and Huntington's disease, protects brain and nerve cells from damage. view more (2006-06-22)
Chemosensitivity of cancer cells depends on their protein dependency
Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, report Brunelle et al. The study will be published online October 26, 2009 and in the November 2, 2009 print issue of the Journal of Cell Biology (JCB). view more (2009-10-26)
What is the function of NOD2 in colonic epithelial cells?
NOD2 is a cytosolic pattern recognition receptor similar in structure and function to Toll like receptors (TLRs). It can recognize and respond to a component found in the cell wall of bacteria, muramyl dipeptide (MDP), and has been shown to play an important role in the innate immune response of macrophages to bacterial infections. view more (2008-10-23)
Antioxidants could provide all-purpose radiation protection
Two common dietary molecules found in legumes and bran could protect DNA from the harmful effects of radiation, researchers from the University of Maryland report. Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in... view more... (2007-11-05)
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