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Commonly used ulcer drugs may offer treatment potential in Alzheimer's disease
In a new study, published in the May issue of Elsevier's Experimental Neurology, scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug. view more (2009-04-22)
Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer. view more (2009-10-29)
Specific Genotype Could Increase Resistance To HIV Drug Therapy (p 383)
A specific mutation of a gene which influences the expression of a glycoprotein transporter protein involved in the body's resistance to drugs and other toxins is detailed in a research letter in this week's issue of THE LANCET. Results of the study suggest that drug therapies used in treating HIV-1 infection (notably protease inhibitors ) may not... view more... (2001-08-01)
New study re-evaluates cardiovascular risks of anti-inflammatory drugs
High doses of some traditional non-steroidal anti-inflammatory drugs (NSAIDS) are associated with similar cardiovascular risks as the new generation of anti-inflammatory drugs known as COX 2 inhibitors (like Vioxx ®), finds a study in this week's BMJ. view more (2006-06-02)
Ace Inhibitors Could Slow Muscle Decline (p 926)
Angiotensin-converting enzyme (ACE) inhibitors, a class of drugs used to lower blood pressure, could also be protective against the decline in muscle strength in elderly women suggest authors of a study in this week's issue of THE LANCET. ACE inhibitors are known to prevent the decline in physical function in patients with congestive heart failure... view more... (2002-03-13)
Future therapies for stroke may block cell death
A new therapy to re-activate silenced genes in patients who suffer from neurodegenerative diseases or stroke is being developed by researchers at the University of Illinois at Chicago and Cornell University. view more (2007-06-14)
First trimester use of ACE inhibitors implicated in birth defects
The Food and Drug Administration is examining study data from Vanderbilt University Medical Center researchers, published this week in the New England Journal of Medicine, to determine if new warnings should be placed on common blood pressure medications indicating an increased risk of birth defects for babies whose mothers take these medications... view more... (2006-06-08)
Massey researchers induce cell death in leukemia
Researchers from the Virginia Commonwealth University Massey Cancer Center today presented preclinical research at the American Association of Cancer Research's annual meeting suggesting the potential of a new combination treatment for chronic lymphocytic leukemia (CLL). view more (2007-04-17)
Leading cancer doctor calls for new guidelines to control early reporting from clinical trials
Hamburg, Germany: A leading breast cancer doctor is urging researchers to consider changing the guidelines that govern whether clinical trials should be stopped prematurely, as she believes that current practice could be damaging research efforts. Dr Martine Piccart, head of the chemotherapy unit at the Institut Jules Bordet, Brussels, Belgium, is... view more... (2004-03-16)
Different anticoagulant regimens yield equal results
Patients with acute coronary syndromes (ACS) receiving early invasive treatment including angiography and percutaneous coronary intervention (PCI) have comparable results at 1 year in terms of mortality and ischemic outcomes no matter which of three different anticoagulant regimens they are on. view more (2007-12-05)
Curacyte scientists discover new anti-tumour agents
Curacyte AG, a Munich-based drug development company focused on novel treatments of inflammatory diseases, thrombotic disorders and cancer has announced today that its scientists have discovered a series of novel small molecule inhibitors of matriptase, a trypsin-like serine protease. Matriptase is an important mediator in the degradation of the... view more... (2003-06-17)
Gene-regulating enzyme is also a target for anti-depressive drugs
In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells. view more (2006-06-26)
Women well-informed about breast cancer, yet lacking knowledge about current treatments
According to a new GfK Roper Public Affairs survey sponsored by CancerCare, a national nonprofit cancer support organization, while the majority (76 percent) of women surveyed said they know at least a fair amount about breast cancer, many remain unaware of the important recent progress made in treatment. view more (2007-06-12)
UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. view more (2005-11-16)
Angiotensin inhibitors and receptor blockers linked to lower risk of nonmelanoma skin cancer
The use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) was associated with a reduced risk of basal cell or squamous cell skin cancers in U.S. veterans, researchers report in the August 26 online issue of the Journal of the National Cancer Institute. view more (2008-08-27)
Developing cancer treatments directed at critical developmental pathway
Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is not universally essential for the maintenance of stem cells. view more (2008-04-11)
Gentech breakthough for ecological Chrysanthemums
Researchers at Plant Research International in the Netherlands have achieved a breakthrough in the development of chrysanthemums with resistance to thrips, bringing the ecological cultivation of chrysanthemums a step closer. This is the conclusion of the thesis with which Seetharam Annadana, a Plant Research International guest member of staff... view more... (2001-12-13)
Blood pressure drugs associated with reduced risk of esophageal, pancreatic and colon cancers
Thousands of individuals currently taking angiotension converting enzyme (ACE) inhibitors, a type of medication commonly used to lower blood pressure, may be doing more than treating their hypertension. view more (2006-05-24)
Uterine cells produce their own estrogen during pregnancy
For decades, scientists assumed that the ovary alone produced steroid hormones during pregnancy. view more (2009-07-21)
Cholinesterase inhibitors reduce aggression, wandering and paranoia in Alzheimer's disease
Cholinesterase inhibitors, used to treat cognitive symptoms of Alzheimer's disease, are also a safe and effective alternative therapy for the behavioral and psychological symptoms of dementia, according to a study that appears in the December 2008 edition of Clinical Interventions in Aging. view more (2008-12-10)
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