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The good and bad side of anti-cancer compounds
Compounds known as "HDAC inhibitors" exhibit cancer-killing activities in cultured cells. While they are currently being tested as anti-cancer agents in clinical trials, just how they execute their effects is unclear. view more (2008-04-11)
Enzyme inhibitors block replication Of SARS virus
Researchers have known since 2003 that a site on the virus is responsible for mediating proteases that allow the virus to replicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional cells in the body. view more (2006-03-28)
COX-2 inhibitors delay pancreatic cancer precursors in mice
Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA. view more (2007-08-02)
Study reveals how some molecules inhibit growth of lung cancer cells
By mapping the interlocking structures of small molecules and mutated protein "receptors" in non-small cell lung cancer (NSCLC) cells, scientists at Dana-Farber Cancer Institute and their colleagues have energized efforts to design molecules that mesh with these receptors, potentially interfering with cancer cell growth and survival. view more (2007-03-13)
Compounds could be new class of cancer drugs
A team of Vanderbilt University Medical Center investigators has developed a group of chemical compounds that could represent a new class of drugs for treating cancer. view more (2009-02-04)
Study identifies potential drug target for Huntington's disease
An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels. view more (2006-07-31)
Switching immunosuppressants reduces cancer risk in kidney
Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA. view more (2009-11-02)
Safety of antithrombotic treatment in acute coronary syndromes
The management of acute coronary syndromes (with or without ST segment elevation) requires the use of anticoagulants, antiplatelet agents (aspirin, clopidogrel and/or glycoprotein (GP) IIb/IIIa inhibitors), beta-blockers, thrombolytics in some cases, and revascularization / reperfusion. view more (2008-09-03)
U of I scientist develops enzyme inhibitor that may slow cancer growth
University of Illinois scientist Tim Garrow, in collaboration with Jiri Jiracek of the Czech Academy of Sciences, has applied for a provisional patent on a class of chemicals that has future therapeutic uses in medicine, specifically cancer treatment. view more (2006-07-07)
Homing in on blood pressure genes may lead to targeted therapy
For the first time, researchers have mapped a genetic location that explains why certain blood pressure-lowering drugs aren't effective for some people, according to researchers at the 2005 American Heart Association High Blood Pressure Research meeting. view more (2005-09-26)
Leeches provide source for cardiovascular drugs
The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases. view more (2005-10-26)
MUHC study reveals Vioxx related heart attacks can occur within the first two weeks of use
A quarter of patients who suffered a heart attack while taking Vioxx did so within the first two weeks of taking the drug, a new study published by MUHC investigators reveals. view more (2006-05-03)
Johns Hopkins scientists discover what drives the development of a fatal form of malaria
Platelets - those tiny, unassuming cells that cause blood to clot and scabs to form when you cut yourself - play an important early role in promoting cerebral malaria, an often lethal complication that occurs mostly in children. view more (2008-08-19)
DRUG TREATMENT HOPE FOR DEMENTIA (pp 2024, 2031)
The drug rivastigmine may significantly alleviate the symptoms of a common form of dementia, concludes research published in this week's issue of THE LANCET. Dementia with Lewy bodies (DLB) is a common form of dementia in older people, affecting between 15 and 25% of all cases. It is characterised by fluctuating cognitive impairment, attention... view more... (2000-12-13)
Drugs to bulk up muscles may make injuries more likely
Block the action of a protein that normally regulates muscle mass, and watch your muscles grow. view more (2008-01-23)
NEW THERAPEUTIC APPROACH TO CORONARY STENTING (p 2037)
Patients given stent implantation to treat coronary heart disease could benefit from a new therapeutic approach with the platelet glycoprotein IIb/IIIa inhibitor eptifibatide, concludes research published in this week's issue of THE LANCET. The platelet glycoprotein IIb/IIIa inhibitors are potent inhibitors of blood clotting. They have previously... view more... (2000-12-13)
The unknown risks of arthritis
Arthritis, in particular rheumatoid arthritis (RA), has devastating effects on the body, causing many debilitating effects and leaving many patients immobile or able to function normally. view more (2006-06-26)
Aspirin and similar drugs may be associated with brain microbleeds in older adults
Individuals who take aspirin or other medications that prevent blood clotting by inhibiting the accumulation of platelets appear more likely to have tiny, asymptomatic areas of bleeding in the brain. view more (2009-04-14)
Molds for Molecules
Molecular imprints in polymers as reaction vessels for pharmaceuticals research Materials with the tiniest of cavities, which can take up other molecules as "guests", play a meaningful role in science and technology. A particularly interesting process for the synthesis of materials with precisely fitted cavities is known as molecular imprinting.... view more... (2002-11-28)
Food peptides activate bitter taste receptors
Researchers from the Monell Center and Tokyo University of Agriculture have used a novel molecular method to identify chemical compounds from common foods that activate human bitter taste receptors. view more (2008-01-23)
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