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Wistar researchers invigorate 'exhausted' immune cells
In battles against chronic infections, the body's key immune cells often become exhausted and ineffective. Researchers at The Wistar Institute have found a way to restore vigor to these killer T cells by blocking a key receptor on their surface, findings that may advance the development of new therapies for diseases such as HIV, hepatitis B and C,... view more... (2008-09-16)
USC researchers discover novel way to develop tumor vaccines
Researchers at the University of Southern California (USC) have uncovered a new way to develop more effective tumor vaccines by turning off the suppression function of regulatory T cells. view more (2008-03-03)
New research shows how chronic stress worsens neurodegenerative disease course
The evidence is accumulating on how bad stress is for health. Chronic stress can intensify inflammation and increase a person's risk for developing central nervous system infections, neurodegenerative diseases, like multiple sclerosis (MS), and other inflammatory diseases. view more (2007-08-20)
Flick of a protein switches immune response
A single protein can turn on and off a key component of the immune system by changing partners in an elegant genomic dance, said researchers at the University of Southern California and Harvard Medical School. view more (2006-07-28)
Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue. view more (2007-12-11)
Researchers map of genetic variations implicated in disease
Sequence differences in less than 0.2% of the 3-billion-base human genome play a vital role in a bewildering variety of human disease. view more (2006-01-27)
Breakthrough developments in rheumatoid arthritis reported
Peter K. Gregersen, MD, stares at x-rays of hands, searching out the telltale signs of inflamed joints and wrists from his research subjects with rheumatoid arthritis. view more (2007-06-11)
A protein in the eye may prevent immune response and protect eyes from disease
Scientists at The Schepens Eye Research Institute have discovered that a protein known as F4/80 found on immune cells in the eye and other parts of the body may have a function in the regulation of the body's immune response and protect delicate tissues that cannot survive the "inflammation" inherent in full-blown immunity. view more (2005-06-22)
Yale study explains complex infection fighting mechanism
Yale School of Medicine researchers report in Nature Immunology how infection fighting mechanisms in the body can distinguish between a virus and the healthy body, shedding new light on auto immune disorders. view more (2006-01-11)
Strategy for mismatched stem cell transplants triggers protection against graft-vs.-host disease
A new technique being tested in stem-cell transplants from imperfectly matched donors has revealed a striking, unforeseen response that can suppress graft-versus-host disease, a common and dangerous complication of mismatched transplants, report scientists from Dana-Farber Cancer Institute. view more (2009-10-08)
Genes in the interferon system important in SLE
Two genes with very strong associations with the disease SLE have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University. The findings are being published today on the Web page of the highly prestigious American Journal of Human Genetics. "These findings are probably the... view more... (2005-01-19)
New origin found for a critical immune response
An immune system response that is critical to the first stages of fighting off viruses and harmful bacteria comes from an entirely different direction than most scientists had thought, according to a finding by researchers at the Duke University Medical Center. view more (2009-03-02)
Resetting epigenetic code could aid lupus patients
Researchers at Wake Forest University School of Medicine and the University of Virginia hope to reset part of the "epigenetic code" in lupus patients and thus improve treatment. view more (2005-11-08)
Scripps research scientists find new genetic mutation that halts the development of lupus
The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease. view more (2008-01-18)
Scientists Exploring Inflammation in Rheumatoid Arthritis Make Unexpected Discovery That One Day May Lead to New Treatments
What makes joints in people with rheumatoid arthritis, and related conditions like Lyme disease or lupus, so susceptible to attack by the body's immune system, leading to painful flare-ups and deterioration? The answer may surprise you. view more (2006-02-16)
SLU researchers show how to stop muscle weakness caused by myasthenia gravis
Severe muscle weakness caused by myasthenia gravis - a highly debilitating autoimmune disorder - can be prevented or reversed by blocking a key step in the immune response that brings on the disease, researchers at the Saint Louis University School of Medicine have found. view more (2007-12-21)
Long term relief from arthritis could evolve from B-cell targeted treatments
Long term relief for arthritis sufferers could be one step closer, thanks to a study of B-cell targeted therapy published today. The study from UCL reveals a major but hitherto poorly acknowledged role for B-cells in the most common and severe form of arthritis to affect younger people. By targeting B-cells, which are part of the body's immune... view more... (2004-06-14)
Dynamic duo: Combination therapy reverses type 1 diabetes
Researchers have now carefully crafted a combination therapy that reverses recent-onset type 1 diabetes in 2 animal models of disease. view more (2006-04-21)
A protein fragment called 12.5 kda cystatin may generate first simple test for multiple sclerosis
Johns Hopkins scientists report the discovery of a protein found only in cerebrospinal fluid that they say might be useful in identifying a subgroup of patients with multiple sclerosis (MS) or identifying those at risk for the debilitating autoimmune disorder. view more (2006-03-03)
Infection-fighting protein could be key to autoimmune disease, say U-M scientists
Scientists at the University of Michigan Medical School have discovered that a protein called cryopyrin responds to invading bacteria by triggering the activation of a powerful inflammatory molecule called IL-1beta, which signals the immune system to attack pathogens and induces fever to protect the body against infection. view more (2006-01-12)
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