Regulatory T cells require WASp if they are to prevent self-destruction
In humans, mutation of the gene encoding a protein known as WASp leads to susceptibility to infections and systemic autoimmunity. view more (2007-01-12)
... susceptibility to infections and systemic autoimmunity. Most studies have focused on understanding the defects in T ... body's own tissues and causing autoimmunity, are also impaired in the absence of WASp.
In the study, ... in their ability to control autoimmunity. Consistent with this, the peripheral blood of a WASp-deficient patient ... to contribute to the systemic autoimmunity from which individuals lacking WASp suffer. ...
The genetic basis for autoimmunity discovered
Researchers from the Basque University have discovered the relationship between E2F2 gene and autoimmunity. The Science Faculty team, leaded by Ana Zubiaga has published the results of its researches in the fifteenth issue of the Immunity magazine. The team began analysing E2F2 gene and its family. This gene family is responsible for the cell... view more... (2002-03-01)
... relationship between E2F2 gene and autoimmunity. The Science Faculty team, leaded by Ana Zubiaga has published ... could be the key of autoimmunity diseases. Autoimmunity diseasesAutoimmunity diseases are the consequence of the wrong function of our ... foreing ones. However, when an autoimmunity defficiency is detected the system is not able to distinguish ... cells, more exactly, to control autoimmunity. Now the same ...
Scientists Develop Method to Track Immune System Enzyme in Live Animals
Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health have created two mouse strains that will permit researchers to trace, in a live animal, the activity of an enzyme believed to play a crucial role both in the normal immune response as well as autoimmunity... view more... (2007-05-18)
... immune response as well as autoimmunity and B cell tumor development. Their report appears in the ... to unwanted results such as autoimmunity and development of B cell tumors, as in the case ... well as in tumorigenesis and autoimmunity," says Casellas. The problem with understanding how AID is regulated ... predisposed to B-cell tumors or autoimmunity to see differences in enzyme expression ...
Omega fatty acid balance can alter immunity and gene expression
For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). view more (2009-06-01)
... risk of inflammation (associated with autoimmunity and allergy), and now using a controlled diet study with ... (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key ... signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune ...
Protein may be linked to melanoma recurrence
Higher levels of a protein called S-100 in patients with melanoma may correlate with a higher risk of having the disease return. view more (2007-06-04)
... response to treatment with interferon. Autoimmunity is an immune response against the body's own tissues.
"With ... patients more likely to develop autoimmunity and to further examine the role of S-100 as a ... potential biomarker for melanoma. ...
'Autoantibodies' may be created in response to bacterial DNA
Autoimmune diseases have long been regarded as illnesses in which the immune system creates autoantibodies to attack the body itself. view more (2009-04-28)
... researchers at the California non-profit Autoimmunity Research Foundation (ARF) explain that the antibodies observed in autoimmune ... disease.
In a paper published in Autoimmunity Reviews, the ARF team, under the guidance of Professor Trevor ... Marshall of Murdoch University, Western Australia, has explained how Homo sapiens must now be viewed as a superorganism in which a plethora of bacterial genomes - a metagenome ...
Common bacteria activating natural killer T cells may cause autoimmune liver disease
A bacteria commonly found in soil and water triggered autoimmune symptoms in mice similar to those found in an incurable liver disease called Primary Biliary Cirrhosis (PBC). view more (2008-05-15)
... and molecular processes to cause autoimmunity remains unknown, as does the cause of PBC. PBC results ... of the liver.
"Our study of autoimmunity in PBC showed that NKT cells react to glycosphingolipid antigens, ... for understanding immunological tolerance and autoimmunity."
Previous research has shown that patients with PBC have a buildup ... in patients. This triggered chronic autoimmunity that damaged small bile ducts in ...
Genetic study confirms the immune system's role in narcolepsy
Scientists funded by the National Institutes of Health have identified a gene associated with narcolepsy, a disorder that causes disabling daytime sleepiness, sleep attacks, irresistible bouts of sleep that can strike at any time, and disturbed sleep at night. view more (2009-05-04)
... system, which strongly suggests that autoimmunity, in which the immune system turns against the body's own ... disorder.
"The link between narcolepsy and autoimmunity was proposed decades ago, but efforts to verify it have ... findings leave little doubt that autoimmunity plays a role," says Merrill Mitler, Ph.D., a program director ... now, the best evidence for autoimmunity as a cause of the disorder ...
New scientific knowledge on juvenile diabetes
Finnish scientists have reported a breakthrough in the attempts to understand the development of type 1 diabetes. They discovered disturbances in lipid and amino acid metabolism in children who later progressed to type 1 diabetes, also known as juvenile diabetes. view more (2008-12-18)
... has been the development of autoimmunity to pancreatic beta cells in the measurable form of islet ... of islet autoantibodies. Although the autoimmunity usually precedes the clinical disease by months to years, its ... lysophosphatidylcholines several months prior to autoimmunity to pancreatic beta cells. The metabolic profile was partially normalized ... following the autoimmune response, suggesting autoimmunity may be a relatively late physiological ...
Worm parasite may hold clues in bid for illness and allergy cures
Tiny worms that can trick the body's natural defences could hold the key to new treatments for a range of conditions, including diabetes, asthma and hay fever. view more (2005-11-08)
... own proteins (a process called autoimmunity) and also prevent it from attacking harmless environmental molecules. It ... to the one that prevents autoimmunity), which tricks the body into switching off the response that ... would otherwise kill the parasites. If that is the case, then infections could be cured, not by vaccination or drug treatment, but by reactivating the immune system. It ...
Vitamin D may exacerbate autoimmune disease
Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate autoimmune disease. view more (2009-04-09)
... but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients ... researchers at the California-based non-profit Autoimmunity Research Foundation, the paper goes on to point out that ... molecular biologists have long known that the form of vitamin D derived from food and supplements, 25-hydroxyvitamin D (25-D), is a secosteroid rather than a vitamin. Like corticosteroid ...
Scripps research scientists find new genetic mutation that halts the development of lupus
The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease. view more (2008-01-18)
... a major role in modulating autoimmunity in transgenic mice. The cloned version of the Lmb3 mutation ... to study these genes for autoimmunity."
Because the actin cytoskeleton is essential for many crucial cellular functions ... all the genes that block autoimmunity one way or another. Finding these suppressing genes may be ... important in identifying future therapeutic targets." ...
Strengthening the tumor-fighting ability of T cells
When faced with cancer, the immune system dispatches cells, called T cells, to kill the tumor. But these killer cells often fail to completely eliminate the tumor because they're deactivated by a distinct population of T cells known as regulatory T cells. view more (2008-03-25)
... attack the body's own tissues (autoimmunity). The mice in the study, however, showed no signs of autoimmune disease, suggesting that OX40 may be a promising target for anti-cancer therapy. ... ...
Don't be a stranger to yourself
One of the most important tasks of the immune system is to identify what is foreign and what is self. If this distinction fails, then the body's own structures will be attacked, the result of which could be an autoimmune disease such as diabetes mellitus type 1 or multiple sclerosis. view more (2009-03-16)
... peripheral organs - and trigger autoimmunity."
In light of the crucial role these cells play, it is ... logical question as to how autoimmunity can be triggered at all without dendritic cells. After all, ... it is the dendritic cells that undertake certain critical tasks during an immune response. "Among other things, they are specialized in presenting antigens to T cells, which is ...
Study Tests Oral Insulin to Prevent Type 1 Diabetes
Researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in at-risk people, the National Institutes of Health (NIH) announced today. view more (2007-02-01)
... In the early stages of autoimmunity, up to 10 years before diabetes is diagnosed, autoantibodies may ... can slow or arrest the autoimmunity of type 1 diabetes. This study has recruited the needed ... that prevent development of the autoimmunity that leads to type 1 diabetes. The NIP study is ... being conducted in:
- babies less than 5 months old who have ... |
