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Stem cell research uncovers mechanism for type 2 diabetes
Taking clues from their stem cell research, investigators at the University of California San Diego (UC San Diego) and Burnham Institute for Medical Research (Burnham) have discovered that a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. view more (2009-02-13)
How does a zebrafish grow a new tail?
If a zebrafish loses a chunk of its tail fin, it'll grow back within a week. Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of cells and is a very intricate structure. It is the fish version of an arm or leg. view more (2006-12-27)
From lung to gut - the Wnt signaling pathway transforms cell fate
Researchers have uncovered a cellular mechanism that can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead. The findings, which are published this week in the top-tier Open Access journal, Journal of Biology, could help researchers hoping to use adult stem cells for therapeutic purposes.... view more... (2004-06-03)
A Novel Strategy for Combating Aids-Related Fungal Infections
Research at the Sir William Dunn School of Pathology has identified Dectin-1 as the beta-glucan receptor on immune cells. This finding may be of use in the prophylactic prevention of a variety of infections, especially in surgical patients, and in the treatment of cancer. The identification of Dectin-1 as the beta-glucan receptor may also provide... view more... (2004-10-08)
Government money for multiple sclerosis patients could be better spent
The National Institute for Clinical Excellence (NICE) has announced that neither interferon beta nor glatiramer can be recommended for multiple sclerosis in the NHS. However, the UK government plans to make these drugs available through a risk sharing scheme, despite limited evidence of clinical and cost effectiveness. Researchers in this week's... view more... (2003-02-12)
Detection Of Antibodies Could Identify MS Patients Who Do Not Respond Well To Interferon Beta (P1184)
Danish research published in this week's issue of THE LANCET highlights how the detection of antibodies to interferon beta-the first choice treatment for multiple sclerosis patients-could be important in identifying patients who do not respond well to interferon beta, with implications for the provision of alternative drug therapy. Interferon beta... view more... (2003-10-08)
Anaemia Treatment Could Worsen Cancer Prognosis (p1255)
Results of a European study in this week's issue of THE LANCET cast doubt over the value of treating anaemia with erythropoietin (epoetin beta) among patients who have cancer. Results of the study show that anaemic patients fare better in terms of reduced cancer progression and increased survival if their anaemia is not treated around the time of... view more... (2003-10-15)
BUDGET FOR INTERFERON BETA FOR MS SUFFERERS WOULD BE BETTER SPENT ON IMPROVED SUPPORTIVE CARE
Dr Raeburn Forbes from Ninewells Hospital and Medical School in Dundee along with colleagues from Argyll and Clyde Health Board and the Scottish Health Purchasing Information Centre studied 132 people with secondary progressive multiple sclerosis and the estimated effect of treating them with interferon beta-1b against existing best practice... view more... (1999-12-08)
Is transforming growth factor-beta involved in intestinal wound healing?
Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation of cell migration, cell differentiation, extracellular matrix deposition, and immune responses. view more (2009-03-31)
Anticancer drugs might be of benefit to sickle-cell patients
Sickle cell disease (SCD) is an inherited blood disorder caused by a genetic mutation that leads to the generation of a mutant form of the beta-globin chain of hemoglobin (Hb). view more (2007-12-07)
Researchers discover mechanism of insulin production that can lead to better treatment for diabetes
How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities. view more (2009-11-13)
Interferons For Treatment Of SARS? (p 293)
Authors of a research letter in this week's issue of THE LANCET suggest that recombinant interferons - synthetic versions of naturally occurring compounds of the immune system - could be a an effective treatment for Severe Acute Respiratory Syndrome (SARS). Although antivirals are probably essential for the treatment of SARS-CoV infection, the... view more... (2003-07-23)
Location, location, location: Transcriptional activity and nuclear position
Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. view more (2006-05-18)
Researchers challenge previous findings regarding widely used asthma treatment
A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown. view more (2008-01-11)
The right messenger for a healthy immune response
Researchers from the Molecular Immunology group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now shown that Beta-Interferon also plays a crucial role during an immune response: without Beta-Interferon immune cells are unable to show "wanted posters" of pathogens to other cells. view more (2009-07-20)
Treatment-induced growth factor causes cancer progression
In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment. view more (2007-04-06)
Human beta-cell line offers hope for type 1 diabetes breakthrough
Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy has been hampered by a severe shortage of donor beta-cells, which are obtained from decreased human donors. view more (2005-09-27)
Glucose levels trigger compensation for type 2 diabetics
Many individuals with type 2 diabetes are diabetic because the cells of their body no longer respond to the hormone insulin, which is crucial for lowering blood sugar levels (blood glucose levels). view more (2007-01-03)
Further Evidence That Vitamin Supplements Do Not Protect Against Cardiovascular Disease (p 2017)
A meta-analysis of randomised trials in this week's issue of THE LANCET provides further evidence that antioxidant vitamins are not effective in reducing the risk of cardiovascular disease. Supplements containing vitamin A compounds could actually contribute to an increase in cardiovascular death and all-cause mortality. Some previous studies have... view more... (2003-06-11)
Carvedilol shown to have unique characteristics among beta blockers
In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity. view more (2009-11-23)
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