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Is endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C?
It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others.   view more (2009-08-27)

Exclusion of common bile duct stones prior to gallstone operations
CBDS occur in 7-20% of all patients undergoing a gallstone operation and may complicate the course of surgery. Although intraoperative x-ray investigation was routinely performed to diagnose CBDS in the pre-laparoscopic era, its use during the laparoscopic era has been debated.   view more (2007-10-31)

TraDIS technique tackles typhoid
For the first time, researchers are able to look at the need for every gene in a bacterial cell in a single experiment. The new method will transform the study of gene activity and the search for weaknesses in bacterial armouries.   view more (2009-10-16)

A new method of pancreaticojejunostomy?
A soft pancreatic texture with a narrow pancreatic ductal size creates a high risk for the development of a pancreatic fistula after pancreaticoduodenectomy, often leading to death. Several methods have been advocated to reduce the occurrence of leakage, but the best technique is still a subject of debate.   view more (2008-03-18)

Researchers find gene that spurs development of the epididymis
Human sperm cells travel up to 6 meters in their transit from testes to penis, and most of that journey occurs in the epididymis, a tightly coiled tube that primes the cells for their ultimate task: fertilization.   view more (2007-06-28)

U of I study: exercise to avoid gallstones!
A new University of Illinois study shows that exercise-trained mice get far fewer gallstones than sedentary mice and identifies potential mechanisms to explain why this occurs.   view more (2008-02-14)

Tissue stiffness drives tumor formation
The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness.   view more (2005-09-23)

Serum bile acid profiling for inflammatory bowel disease characterization
Based on serum bank material, BA profiling was applied in IBD patients and healthy controls which showed that most but not all BA species were decreased to a different extent in CD and UC.   view more (2009-07-16)

Egg whites solve the 3-D problem
The real world is three-dimensional. That's true even in the laboratory, where scientists have to grow cells to study how they develop and what happens when their growth is abnormal.   view more (2008-10-08)

Study looks at off-label use of biliary stents
Although approved by the U.S. Food and Drug Administration as a palliative treatment for cancer patients who have developed bile-duct obstructions, biliary stents are sometimes used "off-label" for the treatment of peripheral vascular disease (PVD).   view more (2008-01-21)

Penn study points to new direction for pancreas cell regeneration
Replacing faulty or missing cells with new insulin-making cells has been the object of diabetes research for the last decade. Past studies in tissue culture have suggested that one type of pancreas cell could be coaxed to transform into insulin-producing islet cells.   view more (2007-04-04)

Subtle changes in normal genes implicated in breast cancer
Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.   view more (2005-07-14)

A case of post-gastrectomy acute pancreatitis
Gastrectomy is commonly performed for both benign and malignant lesions. Although the incidence of post-gastrectomy acute pancreatitis (PGAP) is low compared to other well-recognized post-operative complications, it has been reported to be associated with a high mortality rate.   view more (2009-10-16)

Jefferson Scientists Uncover Lethal Gene Mutation Key to Blocking Cholesterol Processing
When Jefferson Medical College researcher Shiu-Ying Ho, Ph.D., and her colleagues first created a mutation that limited the absorption of lipids and cholesterol into the bloodstream in zebrafish, the possibilities seemed endless.   view more (2006-04-20)

Probiotics affect metabolism, says new study
Probiotics, such as yoghurt drinks containing live bacteria, have a tangible effect on the metabolism, according to the results of a new study published today (Tuesday 15 January) in the journal Molecular Systems Biology.   view more (2008-01-15)

Gene chip discovery may lead to individualized treatment for 5 hereditary liver diseases
Researchers at Cincinnati Children's Hospital Medical Center have developed the first gene chip to use in the early diagnosis of at least five hereditary liver diseases, to detect genetic causes of jaundice in children and adults, and potentially to lead to personalized treatment options.   view more (2006-12-26)

Research team discovers gallstone gene
Scientists at the University of Bonn, together with colleagues from Romania, have discovered a gene variant that significantly increases the risk of developing gallstones (Hepatology No. 46, 11 July 2007, DOI 10.1002/hep.21847).   view more (2007-07-11)

Gallbladder removed without external incisions
In April of last year, surgeons at NewYork-Presbyterian Hospital/Columbia University Medical Center made headlines by removing a women's gallbladder through her uterus using a flexible endoscope, aided by several external incisions for added visibility. Now, they have performed the same procedure without a single external incision in what surgeons... view more... (2008-07-29)

Method shows promise for early detection of pancreatic cancer
Optical technology developed by a Northwestern University biomedical engineer shown to be effective in the early detection of colon cancer now appears promising for detecting pancreatic cancer, the fourth most common cause of cancer deaths in the United States.   view more (2007-08-01)

Mapping the genetic locus for triglycerides
Researchers have mapped out a region on human chromosome 1 that contributes to genetically elevated blood triglyceride levels, a major risk factor for heart disease.   view more (2008-04-28)
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