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How Bacteria get into Brains to Cause Meningitis
An international collaboration between medical researchers may have identified how meningitis causing bacteria cross from the blood into the brain, paving the way for new strategies to prevent this fatal disease, the Society for General Microbiology's Spring Meeting in Edinburgh heard today, Tuesday 8 April 2003. "Almost every known bacteria... view more... (2003-04-02)
Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
A compound that kills cancer can sneak past the blood brain barrier, which protects the brain from foreign substances, to do its work in fighting a particularly invasive brain cancer. view more (2005-08-23)
Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study
In a study using laboratory animals, researchers found that medications commonly prescribed for erectile dysfunction opened a mechanism called the blood-brain tumor barrier and increased delivery of cancer-fighting drugs to malignant brain tumors. view more (2008-07-29)
Genes found to play a role in breast cancer's spread to the brain
New research led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) identifies three genes that specifically mediate the metastasis, or spread, of breast cancer to the brain and illuminates the mechanisms by which this spread occurs. The study was published online today in Nature. view more (2009-05-07)
Kimmel Cancer Center at Jefferson Immunology Researchers Show Blood-Brain Barrier Damage Could Affect MS Severity
Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system's protective blood-brain barrier - in essence, opening it - almost always correlates to the severity of the disease. view more (2007-04-06)
International scientists tackle obstacles to treating brain disorders
A research team led by scientists at the University of Minnesota Medical School and Oregon Health & Science University have outlined the challenges and made suggestions on how to advance research and improve treatments for brain disorders. view more (2007-12-21)
A coffee with your doughnut could protect against Alzheimer's disease
A daily dose of caffeine blocks the disruptive effects of high cholesterol that scientists have linked to Alzheimer's disease. A study in the open access publication, Journal of Neuroinflammation revealed that caffeine equivalent to just one cup of coffee a day could protect the blood-brain barrier (BBB) from damage that occurred with a high-fat... view more... (2008-04-03)
Cerebrospinal fluid used to deliver therapeutics for Lou Gehrig's disease to brain
Researchers from the University of California, San Diego have shown that instead of trying to deliver therapeutic agents for neurodegenerative diseases across the highly impermeable blood-brain barrier via the blood, therapeutic molecules known as antisense oligonucleotides can be delivered to the brain and spinal cord through the cerebrospinal... view more... (2006-07-28)
Hormone shows promise in reversing Alzheimer's disease and stroke
Saint Louis University researchers have identified a novel way of getting a potential treatment for Alzheimer's disease and stroke into the brain where it can do its work. view more (2008-11-12)
Building the blood-brain barrier
Construction of the brain's border fence is supervised by Wnt/b-catenin signaling, report Liebner et al. in The Journal of Cell Biology. view more (2008-10-27)
Alcoholism research reveals promising new approach to treating Alzheimer's disease
Saint Louis University research shows a new class of drugs may hold promise in treating brain chemical problems such as Alzheimer's disease, says the principal investigator of research published in an early on-line version of Peptides. view more (2005-10-26)
Nanoparticles cross blood-brain barrier to enable 'brain tumor painting'
Brain cancer is among the deadliest of cancers. It's also one of the hardest to treat. view more (2009-08-04)
Alzheimer disease and the blood brain barrier: Is Abeta transport the key?
Increased production of the amyloid-beta (Abeta) peptide can lead to Abeta aggregation and buildup in the brain and rare familial forms of early onset Alzheimer disease (AD). view more (2005-10-21)
Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest
The anti-inflammatory drug indomethacin could hold promise as a treatment for Alzheimer's disease, says a Saint Louis University doctor and researcher. view more (2009-07-09)
GEN reports on strategies to overcome blood-brain barrier
The blood-brain barrier (BBB) remains a major obstacle to the successful delivery of drugs to treat central nervous system (CNS) disorders, reports Genetic Engineering and Biotechnology News (GEN). view more (2009-02-06)
Brain study may lead to improved epilepsy treatments
Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain. view more (2008-04-15)
University of Iowa scientists use blood-brain barrier as therapy delivery system
The blood brain barrier is generally considered an obstacle to delivering therapies from the bloodstream to the brain. However, University of Iowa researchers have discovered a way to turn the blood vessels surrounding brain cells into a production and delivery system for getting therapeutic molecules directly into brain cells. view more (2009-09-22)
Some blood pressure drugs may help protect against dementia, study shows
A particular class of medication used to treat high blood pressure could protect older adults against memory decline and other impairments in cognitive function, according to a newly published study from Wake Forest University School of Medicine. view more (2009-07-23)
How meningitis bacteria attack the brain
A specific protein on the surface of a common bacterial pathogen allows the bacteria to leave the bloodstream and enter the brain, initiating the deadly infection known as meningitis. view more (2009-08-19)
Leukemia drug could save lives of stroke patients
The drug tPA is the most effective treatment currently available for stroke patients, but its safety is limited to use within the first three hours following the onset of symptoms. view more (2008-06-23)
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