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Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
Effector T cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population.   view more (2006-06-16)

Triple Risk For Smokers With Faulty Gene
Smokers who inherit a particular genetic trait could triple their chances of getting lung cancer according to a report in the British Journal of Cancer.* While tobacco is the biggest cause of lung cancer. the risk of developing it varies. This has led scientists to believe that genetics may have a... view more (2002-07-09)

Jefferson scientists explain cancer cell metabolism changes
Scientists at Jefferson Medical College and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have found how a gene can dim the power production in the cell and in turn scale up its cancer-producing activities.   view more (2006-08-29)

Stem cell indicator for bowel cancer should lead to better survival rates
Stem cell scientists have developed a more accurate way of identifying aggressive forms of bowel cancer, which should eventually lead to better treatment and survival rates. Bowel cancer is the third most common cancer in the UK.   view more (2008-08-20)

Cancer drug extends cognitive function in patients with brain metastases
he drug Xcytrin®, based on a molecule developed by chemists at The University of Texas at Austin, shows significant promise in prolonging cognitive function in patients with non-small cell lung cancer that has metastasized to the brain.   view more (2006-06-06)

Drug fends off kidney cancer progression
New data from an international, multicenter Phase III clinical trial has found that the experimental targeted therapy everolimus (RAD001) significantly delays cancer progression in patients with metastatic kidney cancer whose disease had worsened on other treatments.   view more (2008-05-19)

Study reveals how some molecules inhibit growth of lung cancer cells
By mapping the interlocking structures of small molecules and mutated protein "receptors" in non-small cell lung cancer (NSCLC) cells, scientists at Dana-Farber Cancer Institute and their colleagues have energized efforts to design molecules that mesh with these receptors, potentially... view more (2007-03-13)

Increased hepcidin expression: A novel oncogenic signalling mechanism
Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss. Previous studies have elegantly shown that the anti-microbial peptide hepcidin can also induce anaemia as a consequence of infection and or inflammation.   view more (2008-03-19)

Lung cancer survival rates may be linked to access to care
New research suggests that the lower survival rates of blacks with lung cancer may be explained by access to care.   view more (2006-02-06)

Dual-drug therapy targets one colon cancer gene
Johns Hopkins Kimmel Cancer Center scientists have found that interferon, used for 30 years to treat blood cancers, multiple sclerosis and hepatitis, selectively kills colon cancer cells when combined with another standard chemotherapy agent.   view more (2005-08-18)

MRI drug may improve cancer-killing ability of chemotherapy, study says
A contrast agent currently used in magnetic resonance imaging (MRI), called mangafodipir, may increase the cancer-killing ability of some chemotherapy drugs while protecting normal cells.   view more (2006-02-15)

Inflammatory biomarker helps identify progressive precancerous lesions in the lung
C-reactive protein (CRP), a biomarker for inflammation in the blood, can help to identify individuals whose abnormal precancerous lesions will advance closer to invasive lung cancer.   view more (2006-03-01)

Scientists stop colon cancer growth in mice by blocking just one enzyme
In cell culture experiments, scientists from the University of Texas Medical Branch at Galveston (UTMB) and the University of Texas at Arlington determined that stopping the activity of a single enzyme called aldose reductase could shut down the toxic network of biochemical signals that promotes... view more (2006-10-02)

Discovery suggests why stem cells run through stop signs
Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point... view more (2005-06-13)

Mayo discovers protein as potential tactic to prevent tumors
Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication.   view more (2006-10-13)

FDG-PET Imaging Clearly Predicts Lung Cancer Patients' Response to Chemotherapy
An earlier indication of whether chemotherapy benefits non-small cell lung cancer patients—provided by positron emission tomography (PET) imaging—can guide doctors in offering them better care, according to researchers in the May Journal of Nuclear Medicine.   view more (2007-05-10)

'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers
More than 30 years ago, Alfred Knudson Jr., M.D., Ph.D., revolutionized the field of cancer genetics by showing that a person must lose both their paternal and maternal copies of a particular class of cancer-inhibiting genes, called tumor-suppressor genes, in order to develop cancer.   view more (2008-09-15)

Evolution and the workaround
Living things are resourceful, which is a comforting thought unless the living thing in question is a pathogen or a cancer cell. Noxious cells excel at developing drug resistance, outwitting immune systems, and evading cellular controls.   view more (2006-12-11)

A search for biomarkers for early detection of colorectal cancer
Researchers at the Zhejiang University, Hangzhou have discovered that mimecan and Thioredoxin Domain-Containing Protein 5 (TXNDC5) were differentially expressed in colorectal adenoma.   view more (2007-09-25)

Protein protects anti-cancer gene from chemical shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced.   view more (2007-07-20)

Promising cell protein may play role in infection and dry eye
Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye.   view more (2006-05-17)

Preliminary study shows promise for treatment of renal cell cancer
A new study suggests that sunitinib is a promising agent for treatment of metastatic renal cell cancer, currently a disease without highly effective treatment options.   view more (2006-06-07)

Pioneering study looks at p53's role in tumor-stroma interactions
Researchers at Emory University's Winship Cancer Institute have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development.   view more (2006-10-26)

Vitamin D and calcium influence cell death in the colon, researchers find
Researchers at Emory University are learning how vitamins and minerals in the diet can stimulate or prevent the appearance of colon cancer.   view more (2008-04-14)

Basis created for directing and filming blood vessels
A new method of filming blood-vessel cells that move in accordance with targeted signals has been developed by researchers at Uppsala University in collaboration with researchers at the University of California. The method can also be used to study how migration of cancer cells and nerves can be... view more (2008-03-27)
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