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Cancer Gene Current Events | Cancer Gene News | 6

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Case Western Reserve University researchers identify colorectal cancer gene
Case Western Reserve University School of Medicine researchers published a study in the March 7th issue of The American Journal of Human Genetics identifying the hereditary components of colorectal cancer (CRC.) "Identification of Susceptibility Genes for Cancer in a Genome-wide Scan: Results from the Colon Neoplasia Sibling Study" is... view more... (2008-03-10)

Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread.   view more (2008-01-18)

High risk of breast cancer associated with genetic variation in leptin and its receptor
Individuals with either of two genetic variations that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others.   view more (2006-02-21)

A new gene for familial cancer was found
A research group at the University of Helsinki, Finland, has found a gene defect that causes hereditary colorectal cancer and defects in dentition. The finding was published online on March 23 in the American Journal of Human Genetics. The groups led by professors Sinikka Pirinen and Irma Thesleff at the Institute of Dentistry and Institute of... view more... (2004-03-26)

Mayo Clinic Cancer Center finds possible genetic link to pancreatic cancer
Mayo Clinic researchers have found the risk of developing pancreatic cancer at a young age (under 60) to be twice as high for people who carry a mutation of the gene that causes cystic fibrosis, compared to noncarriers.   view more (2005-10-21)

Fish cancer gene linked to pigment pattern that attracts mates
Though skin cancer is deadly to male fish, it also has one perk: The black melanoma splotches arise from attractive natural markings that lure female mates. A new study published in the Proceedings of the National Academy of Sciences this week shows that the melanoma gene can be conserved in swordtail fish because of its beneficial role in sexual... view more... (2008-08-19)

Whole genome promoter mapping - Human Genome Project v2.0?
nvestigators from the University California, San Diego (UCSD) Branch of the Ludwig Institute for Cancer Research (LICR) and NimbleGen Systems have developed an efficient method to identify thousands of regulatory sequences in the human genome, according to a study published today in Nature.   view more (2005-06-30)

Defective genes increase breast cancer risk in young women to a greater extent than previously estimated
A joint study between St Mary's Hospital, the Paterson Institute, Christie Hospital, The University of Manchester, Guys Hospital in London, and Cambridge University researching breast cancer has found that women with defects in certain genes have a higher chance of developing breast cancer when they are young than previous estimates. The report... view more... (2003-04-02)

Core needle biopsy gives an accurate picture of gene expression in whole tumor
The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour.   view more (2006-08-21)

Poor prognosis linked to BRCA1 mutations - but may be improved by chemotherapy
Breast cancer patients have a lower chance of long-term survival if they carry an inherited mutation in the BRCA1 gene, according to research published in Breast Cancer Research this week. However, the poor prognosis associated with the mutated gene is mitigated by chemotherapy. The breast cancer susceptibility genes, BRCA1 and BRCA2, were... view more... (2003-10-20)

Researchers identify cancer-causing gene in many colon cancers
Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer.   view more (2008-09-15)

Fox Chase Researchers Uncover One Force Behind the MYC Oncogene in Many Cancers
DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center.    view more (2009-07-29)

Key to lung cancer chemo resistance revealed
Scientists at Johns Hopkins have discovered how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer.   view more (2006-10-11)

Study examines association between type of genetic characteristics and cancer
Persons with a certain type of homozygosity (having two identical copies of the same gene, one inherited from each parent), may have a greater predisposition to cancer, according to a study in the March 26 issue of JAMA.   view more (2008-03-26)

A gene for metastasis
Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver.   view more (2007-08-28)

Penn researchers discover genetic risk factor for testicular cancer
Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer.   view more (2009-06-01)

Gene dose affects tumor growth
Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model.   view more (2008-01-04)

Study finds 231 new genes associated with head and neck cancer
A Henry Ford Hospital study has identified 231 new genes associated with head and neck cancer, one of the most deadly cancers responsible for 2.1 percent of all cancer deaths in the United States.   view more (2009-10-05)

New molecules discovered that block cancer cells from modifying cell DNA
Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells.   view more (2007-10-12)

Study demonstrates how gene variant may contribute to cancer development
A relatively common cancer susceptibility gene appears to be frequently acquired in metastatic lesions from colorectal cancer, and give cancer cells a growth advantage, according to a study in the October 5 issue of JAMA.   view more (2005-10-05)
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