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Cancer Gene Current Events | Cancer Gene News | 7
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Researchers identify gene set linked to breast cancer's spread to lungs
In a potential advance for the treatment of aggressive breast cancer, scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have identified a set of genes in breast tumors that appear to predict if the disease will spread to the lungs and, once there, how virulent it will become.   view more (2005-07-28)

Breast cancer risk amplified by additional genes in combo with BRCA mutation
Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published this month in the American Journal of Human Genetics.   view more (2008-04-17)

Resistance to chemotherapy in lung cancer, optimizing flu vaccination strategies
Lung cancer is the most common cause of cancer-related death worldwide, in part because these tumors often are or become resistant to chemotherapy.   view more (2006-10-03)

Unique role for blood formation gene identified
All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found.   view more (2007-09-13)

Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers
There is a broad variation in the risk of developing breast cancer among people who carry the BRCA1 and BRCA2 gene mutation, according to a study in the January 9/16 issue of JAMA.   view more (2008-01-09)

Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat.   view more (2008-05-19)

Study shows liver an excellent target for cancer gene therapy using viral vectors
A featured paper in the February 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells.   view more (2007-02-15)

Jefferson Scientists Identify Gene Mutation Potentially Involved in Breast Cancer Initiation
Researchers at Jefferson Medical College and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia and at the Albert Einstein College of Medicine in New York have found evidence suggesting that a mutation in a gene that normally helps block the formation of breast tumors could... view more (2006-06-01)

Cells united against cancer
Sheets of highly organized epithelial cells line all the cavities and free surfaces of the body, forming barriers that control the movement of liquids and cells in the body organs.   view more (2007-08-28)

Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of Texas M. D. Anderson Cancer Center reported in the current issue of the... view more (2008-05-23)

Inventory of Genes
Scientists at DKFZ screen fruit fly genome for cancer-relevant genes Dr. Michael Boutros of the Deutsches Krebsforschungszentrum (German Cancer Research Center, DKFZ) and an international team of collaborators have been the first to screen an almost complete genome for genes that could play a role... view more (2004-02-09)

Tissue engineering technique does not cause tumor growth
A gene therapy approach used in creating new arteries for older patients does not appear to cause cancer, according to a pilot study by Yale School of Medicine researchers reported in the Proceedings of the National Academy of Sciences.   view more (2006-03-01)

Potential new target for cancer found
By bypassing a well-known gene implicated in almost one-third of all cancers and instead focusing on the protein activated by the gene, Duke University Medical Center researchers believe they may have found a new target for anti-cancer drugs.   view more (2007-07-16)

Tumor genome analysis unveils new insights into lung cancer
An international consortium of scientists today in an advanced online publication in the journal Nature revealed a comprehensive view of the altered genetic background of the type of lung cancer that is the most common cause of cancer deaths in humans.   view more (2007-11-05)

Suppression of FOXO1a gene might kill resistant ARMS tumors
The loss of function of a gene called FOXO1a plays an important role in the development of the most common cancer of soft tissues in children, and restoring the function of that gene in cancer cells suppresses that cancer.   view more (2005-09-22)

Chemical genomic screening identifies novel therapeutic strategies for cancer
A sophisticated new chemical genetic screening strategy that serves as a tool for identifying anticancer compounds may significantly enhance the drug discovery process.   view more (2006-09-29)

Study uncovers mechanism of drug resistance in form of lung cancer
Dana-Farber Cancer Institute researchers and their colleagues have demonstrated that a genetic error so scarce it can't be detected with some standard screening equipment is often responsible for the loss of effectiveness of front-line drugs against non-small cell lung cancer.   view more (2006-09-07)

Study raises questions about prostate cancer therapies targeting IGF-1
Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators... view more (2008-05-01)

New gene discovery that stops skin cancer in its tracks
Tumour Suppressor Genes (TSGs) are important in controlling the growth of cells. Cancer is caused when cells multiply uncontrollably, so the TSGs play a vital role in stopping healthy cells from becoming cancerous. Experts already know that one particular TSG called P16 is able to stop the growth... view more (1999-02-22)

New test offers hope of easy and affordable screening for hereditary breast cancer genes
Researchers at the Nottingham Breast Unit in the UK have developed an easy and affordable way of screening families for underlying hereditary genetic mutations which predispose them to developing breast cancer, the 3rd European Breast Cancer Conference in Barcelona heard today (Wednesday 20 March).... view more (2002-03-18)

UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer.   view more (2005-11-16)

UNC study questions FDA genetic-screening guidelines for cancer drug
Not everyone needs a genetic test before taking the cancer drug irinotecan, and the U.S. Food and Drug Administration should modify its prescription guidelines to say so, according to researchers at the University of North Carolina at Chapel Hill.   view more (2007-08-29)

Gene loss accelerates aging
Researchers have discovered that the loss of a gene called p63 accelerates aging in mice. Similar versions of the gene are present in many organisms, including humans. Therefore, the p63 gene is likely to play a fundamental biological role in aging-related processes.   view more (2005-08-17)

Cancer-killing viruses influence tumor blood-vessel growth
Viruses genetically designed to kill cancer cells offer a promising strategy for treating incurable brain tumors such as glioblastoma, but the body's natural defenses often eliminate the viruses before they can eliminate the tumor.   view more (2008-06-11)

Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.   view more (2007-04-30)
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