Cell Death Current Events | Cell Death News | 11
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Targeting leukemic stem cells by Bcl-2 inhibition
Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemia (AML) blast, progenitor and even stem cells that are often resistant to standard chemotherapy treatment. view more (2006-11-20)
Antibody retards growth and induces death in liver cancer cells
Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics. view more (2007-07-12)
Link between stress and heart disease may be premature
It has often been claimed that psychological stress is an important cause of heart disease, but a study in this week's BMJ shows that previous research may have been misleading. Researchers measured self-assessed stress amongst middle-aged Scottish men working in and around Glasgow in the early 1970s. These men were then followed for more than... view more... (2002-05-22)
New research findings may enable earlier diagnosis of uterine cancer
Cancer is a genetic disease. It occurs when changes take place in the genes that regulate cell division, cell growth, cell death, cell signalling and blood vessel formation - either due to mutations caused by external factors such as smoking or radiation - or due to inherited changes. view more (2009-01-28)
Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
Extensive death of nerve cells leads to severe dementia in patients with Alzheimer's disease. Until now, it has only been possible to investigate the neuronal devastation in post mortem animal models, and by using complicated methods. view more (2009-04-15)
Homeless people are more likely to die early
Homeless people staying in hostels are four times more likely to die early than people in the general population, claim researchers in this week's BMJ. The study involved over 750 people staying in two hostels for the homeless in Copenhagen in 1991. Some were interviewed about several aspects of their lives including upbringing, family background,... view more... (2003-07-09)
Different forms of amyloid beta in Alzheimer's disease harm neurons in different ways
Researchers at UC Irvine have shown that different forms of amyloid beta lead to neural damage in different ways, leading to an increasingly complex view of amyloid toxicity in the Alzheimer brain. view more (2006-06-01)
Progression of retinal disease linked to cell starvation
Rods and cones coexist peacefully in healthy retinas. Both types of cells occupy the same layer of tissue and send signals when they detect light, which is the first step in vision. view more (2008-12-08)
Mounting a multi-layered attack on fungal infections
Unravelling a microbe's multilayer defence mechanisms could lead to effective new treatments for potentially lethal fungal infections in cancer patients and others whose natural immunity is weakened. view more (2009-09-08)
Retinoid cream associated with death in clinical trial, but relationship does not appear causal
Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result. view more (2009-01-20)
HIV conquers immune system faster than previously realized
New research into the earliest events occurring immediately upon infection with HIV-I shows that the virus deals a stunning blow to the immune system earlier than was previously understood. view more (2008-07-21)
Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
A protein long thought to provide only mechanical support for keeping cells and tissues from literally falling apart turns out to have much wider utility. view more (2006-05-18)
Blocking one protein helps cancer cells die of natural causes
Researchers have identified a protein fragment that keeps at least one major tumor suppressor gene from preventing cancer like it should. The fragment belongs to a class of proteins known as apoptotic enhancers (ASPP), named for their ability to stimulate programmed cell death, or apoptosis, by the p53 gene. But a study published in Nature... view more... (2003-01-08)
Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
Blocking signals from a key molecular receptor that normally switches on the intestine's immune response but instead becomes too intense in the presence of stress and toxins may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature newborns. view more (2007-12-03)
Kaposi sarcoma arises independently from multiple cells
Kaposi sarcoma is unique among cancers because most tumors grow from a small number of different cells, whereas nearly all other cancers arise from a single cell. view more (2007-07-11)
Cellular discovery may lead to targeted treatment for rare form of anemia
University of Cincinnati (UC) researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, their discoveries could result in drastic changes to current thinking about treatment for this disease and may lead to... view more... (2009-03-16)
Alzheimer's: New findings resolve long dispute about how the disease might kill brain cells
For a decade, Alzheimer's disease researchers have been entrenched in debate about one of the mechanisms believed to be responsible for brain cell death and memory loss in the illness. view more (2009-04-16)
Researchers find predictor of mortality in cardiac patients
Researchers at SUNY Downstate Medical Center in Brooklyn have determined that low levels of a protein in the blood is a predictor of cardiac death in patients with coronary artery disease. view more (2007-02-21)
Being overweight just as risky to health as being a smoker
Obese adolescents have the same risk of premature death in adulthood as people who smoke more than 10 cigarettes a day, while those who are overweight have the same risk as less heavy smokers, according to research published on bmj.com today. view more (2009-02-25)
Fish oil may help protect against retinal degenerative diseases
A invited paper published in Trends in Neuroscience this week by Nicolas G. Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center in New Orleans, reports on the role that the omega-3 fatty acids in fish oil play in protecting cells in the retina from degenerative diseases like retinitis... view more... (2006-04-06)
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