Cell Death Current Events | Cell Death News | 2
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Drug compound leads to death of ovarian cancer cells resistant to chemotherapy In a discovery that may be useful for maintaining remission in chemo-resistant ovarian cancer, Yale scientists report that pre-clinical studies have shown the drug compound NV-128 can induce the death of ovarian cancer cells by halting the activation of a protein pathway called mTOR. view more (2008-04-18)
Network model predicts risk of death in sickle cell disease Researchers from Boston University School of Medicine (BUSM) and Boston University School of Public Health (BUSPH) have developed a method to estimate sickle cell disease severity and predict the risk of death in people with this disease. view more (2007-07-12)
Breakthrough in understanding of blood vessel inflammation Medical scientists at the University of Leicester have announced a breakthrough in their understanding of blood vessel inflammation - a serious condition which underlies health problems like organ failure in sepsis, the ability to recover from burns, and transplant rejection. The team in the Department of Cardiovascular Sciences at the University... view more... (2004-01-19)
What is the role of reactive oxygen species in ethanol-mediated cell death of polarized hepatic cells? Liver disease that results as a consequence of alcohol abuse is a major medical problem worldwide. Ethanol consumption leads to a variety of liver alterations including the accumulation of fat, inflammation of the liver, as well as the presence of scar tissue. view more (2009-06-15)
New understanding about mechanism for cell death after stroke leads to possible therapy Scientists at the Brain Research Centre, a partnership of the University of British Columbia Faculty of Medicine and Vancouver Coastal Health Research Institute, have uncovered new information about the mechanism by which brain cells die following a stroke, as well as a possible way to mitigate that damage. view more (2009-11-23)
Elevated testosterone kills nerve cells A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells. view more (2006-09-27)
Critical link in cell death pathway revealed The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions. view more (2009-07-23)
Scientists explain how 'death receptors' designed to kill our cells may make them stronger It turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger. view more (2009-06-02)
Hemangioma arteriovenous malformations or how endothelial cells escape apoptosis (programmed cell death). Hemangiomas included several types of vascular abnormalities. The first classification of vascular abnormalities was proposed in 1982. Since angiography is becoming a common investigation, a better identification of the vascular abnormalities was possible. Hemangiomas are frequent in children and are present in 10 to 12 new born babies.... view more... (1999-09-14)
A new jump start for aging blood vessels Recent studies show promise for significantly reducing vascular aging by inactivating TNFa, which has been linked to blood vessel dysfunction and cell death. The related report by Csiszar et al., "Vasculoprotective effects of anti-TNFa treatment in aging," appears in the January issue of The American Journal of Pathology. view more (2006-12-28)
Unfolded proteins may protect cells from dying When cells get stressed, their proteins go unfolded. It's a reaction with a straightforward name: the unfolded protein response. Now, new research from Rockefeller University shows that this phenomenon actually serves a protective role; rather than a sign that the cell has given up, it may be a mechanism by which the cells cope with adversity. view more (2006-12-27)
By amplifying cell death signals, scientists make precancerous cells self-destruct When a cell begins to multiply in a dangerously abnormal way, a series of death signals trigger it to self-destruct before it turns cancerous. Now, in research to appear in the August 15 issue of Genes & Development, Rockefeller University scientists have figured out a way in mice to amplify the signals that tell these precancerous cells to... view more... (2008-08-18)
Heart attack in a laboratory dish NWO researchers at Utrecht University have given heart muscle cells a heart attack in the laboratory. This allowed them to observe clearly the change that takes place in the cell membrane during an attack and how the change sometimes leads to the death of the cell. In a healthy cell, one of the components of the membrane, the phospholipids, are... view more... (2001-05-08)
Scientists find a key culprit in stroke brain cell damage Researchers have identified a key player in the killing of brain cells after a stroke or a seizure. The protein asparagine endopeptidase (AEP) unleashes enzymes that break down brain cells' DNA, scientists at Emory University School of Medicine have found. view more (2008-03-28)
How do infections and toxins launch a cell's self-destruct and alarm system? Cells are coded with several programs for self-destruction. Many cells die peacefully. Others cause a ruckus on their way out. view more (2008-03-11)
Cell's split personality is a major discovery into neurological diseases Researchers at the Université de Montreal (UdeM) and the Montreal Neurological Institute (MNI), McGill University have discovered that cells which normally support nerve cell (neuron) survival also play an active and major role in the death of neurons in the eye. view more (2009-05-08)
Protein That Promotes Cancer Cell Growth Identified Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. view more (2009-07-27)
Wellcome Trust grant to investigate degenerative brain diseases known as `tauopathies` Dr Julian Thorpe, head of the Electron Microscopy Lab at the University of Sussex, will be working towards a better understanding of degenerative brain diseases thanks to a £247,000 grant from the Wellcome Trust. He is taking a very close look at a possible contributory cause of nerve cell death in a group of conditions related to... view more... (2002-04-17)
Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat. view more (2008-05-19)
What are protective effects of anti-ricin A-chain aptamer? Ricin, a lectin from the castor bean plant Ricinus communis is considered one of the most potent plant toxins. Ricin poisoning can cause severe tissue damage and inflammation and can result in death. view more (2008-12-29)
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