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Paradigm shift: Switch for programmed cell death promotes spread of glioblastoma
Malignant tumors have usually lost their ability to destroy themselves by programmed cell death, or apoptosis. Therefore, tumors are often resistant to chemotherapy or radiation therapy, whose effect is based on forcing tumor cells to commit suicide. view more (2008-03-12)
Wide variation by ambulance crews of when to stop resuscitating patients
The point at which crews are allowed to recognise that a patient has died or that life-saving resuscitation attempts are no longer warranted, varies widely among UK ambulance services, reveals research in Emergency Medicine Journal. This is despite the publication of national, validated guidelines in 1996, which apply to all adults who have not... view more... (2002-07-08)
Finnish study identifies factors that increase death in stroke patients ages 15 to 49
Heavy drinking, being 45 to 49 years old, type 1 diabetes or having a preceding infection are associated with more than twice the risk of death in stroke patients 15 to 49 years old, according to a Finnish study. view more (2009-07-10)
Preventing spinal cord injury during aortic surgery
Surgery to repair aortic aneurysms often comes with a high price: neurological deficits, but new research points to a possible defense against spinal cord injury during aortic surgery. view more (2006-06-22)
Pathogen virulence proteins suppress plant immunity
Researchers from the Virginia Bioinformatics Institute (VBI) at Virginia Tech and their colleagues have identified a key function of a large family of virulence proteins that play an important role in the production of infectious disease by the plant pathogen Phytophthora sojae. view more (2008-04-22)
Potential New Therapeutic Molecular Target to Fight Cancer
Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer. view more (2007-11-02)
'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Tumor cells living in the cross hairs of radiation or chemotherapy may be able to escape death because their self-destruct mechanisms are jammed, say University of Florida scientists writing in a recent issue of Developmental Cell. view more (2008-05-01)
Improving understanding of cell behaviour in breast cancer
The invasion and spread of cancer cells to other parts of the body, known as metastasis, is a principal cause of death in patients diagnosed with breast cancer. view more (2008-07-16)
Immunisation is not linked to sudden infant death
Vaccination against diphtheria, tetanus and pertussis is now given at ages 2, 3 and 4 months in the UK, which coincides with the peak age for the sudden infant death syndrome (SIDS). However, a study in this week's BMJ finds that immunisation is not linked to sudden unexpected death in infancy and may even protect against it. All sudden unexpected... view more... (2001-04-03)
When preventing pre-eclampsia, a little carbon monoxide goes a long way
Researchers have shown that carbon monoxide may prevent the placental cell death caused by oxidative stress injury, possibly averting the risks of pre-eclampsia. view more (2006-09-05)
Retinol for combating leukemia cells
Vitamin A, also known as retinol, is present in milk, liver, egg yolk, butter and other foodstuffs and as carotene in vegetables that have a yellow-orange colour, such as carrots and pumpkins. view more (2006-01-09)
Fatigue is an important factor in serious road crashes
Fatigue, especially when combined with alcohol, presents a particularly high risk of road crashes resulting in death or serious injury, finds a study in this week's BMJ. Data from the French Ministry of Transport was used to investigate the role of fatigue in serious, single-vehicle crashes during 1994-8. About 10% of the crashes were related to... view more... (2001-04-03)
Increased Parental Mortality After Death Of A Child (p 363)
Danish authors of a study in this week's issue of THE LANCET provide strong evidence for the first time that experiencing the death of a child increases the mortality rate of parents-with mothers being far more likely to die early than fathers. There has been no clear evidence to suggest that the death of a child is associated... view more... (2003-01-29)
Very young babies vulnerable to sudden death while seated
Very young babies are vulnerable to sudden death, when seated, warns a study published ahead of print in the Archives of Disease in Childhood. view more (2007-07-19)
Natural protein may halt colorectal cancer's spread
Medical College of Wisconsin Cancer Center researchers in Milwaukee have learned that a protein, CXCL12, that normally controls intestinal cell movement, has the potential to halt colorectal cancer spreading. view more (2009-04-21)
Treating HIV earlier to decrease the risk of death
Begin treatment as early as possible: this general common sense rule seems to apply to most diseases except HIV-AIDS, which is only treated once a certain number of immune cells called "CD4+" cells have disappeared. view more (2009-04-15)
New therapeutic target for melanoma identified
A protein called Mcl-1 plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis, according to research published this week in Molecular Cancer Research. view more (2009-04-16)
Chemosensitivity of cancer cells depends on their protein dependency
Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, report Brunelle et al. The study will be published online October 26, 2009 and in the November 2, 2009 print issue of the Journal of Cell Biology (JCB). view more (2009-10-26)
Timely Antiretroviral Therapy Essential For Best Prognosis In People With HIV-1 Infection (p 119)
Authors of an international study in this week's issue of THE LANCET highlight how timely treatment with highly-active antiretroviral therapy (HAART) can substantially improve the three-year prognosis for people with HIV-1 infection. HAART became widespread in more-developed countries in 1996. However, there is insufficient data from individual... view more... (2002-07-10)
Anesthesia and Alzheimer's
In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein. view more (2008-04-28)
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