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Targeting the more lethal form of the cancer rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). view more (2009-05-26)
Joslin-led study reveals findings on how insulin-producing beta cells grow and function
Joslin-led study reveals findings on how insulin-producing beta cells grow and function view more (2006-04-24)
A new focus for the mechanism of nerve growth
Researchers at Yale shed new light on the mechanism of nerve cell growth by identifying novel functions for a molecular "motor" protein, myosin-II, according to an article in the March issue of Nature Cell Biology. view more (2006-03-20)
New compound 'highly efficacious' at reducing human tumour growth
Innsbruck, Austria: Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr Gerhard Siemeister of Schering AG, Corporate Research, Berlin speaking at the 18th meeting of the European Association of Cancer... view more... (2004-07-06)
Joslin-led study uncovers role of appetite hormone MCH in insulin production
A new Joslin Diabetes Center-led study has shown conclusively that a neuropeptide, melanin concentrating hormone (MCH), found in the brain and known for its role in increasing appetite in people, plays a role in the growth of insulin-producing beta cells and the secretion of insulin. view more (2007-01-29)
Big and fast growing infants at greater risk of later obesity
Large infants, and those who grow rapidly during the first two years of life, are at increased risk of obesity in childhood and adulthood, a study published online by the BMJ today (14 October 2005) has found. view more (2005-10-14)
Hormone clue to root growth
Plant roots provide the crops we eat with water, nutrients and anchorage. Understanding how roots grow and how hormones control that growth is crucial to improving crop yields, which will be necessary to address food security and produce better biofuels. view more (2009-07-08)
Omega-6 fats cause prostate tumors to grow twice as fast
Omega-6 fatty acids-such as those found in corn oil-caused human prostate tumors in cell culture to grow twice as quickly as tumors to which omega-6 fats had not been added, according to a study conducted at the San Francisco VA Medical Center. view more (2006-02-01)
Master regulator found for regenerating nerve fibers in live animals
Researchers at Children's Hospital Boston report that an enzyme known as Mst3b, previously identified in their lab, is essential for regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral and central nervous systems. view more (2009-10-26)
Growth factors given with chemotherapy associated with increased risk of blood diseases
Women with breast cancer who receive compounds that stimulate white blood cell production to help their bodies better tolerate chemotherapy are at an increased risk of developing a type of leukemia or a condition called myelodysplastic syndrome. view more (2007-02-07)
Glypican-3 gene function in regulating body size helps inform novel cancer treatments
In a leading study that has implications for the development of novel therapies for a number of breast, lung and ovarian cancers that have lost the expression of a gene called glypican-3 (GPC3), Sunnybrook researchers have discovered how the loss of the GPC3 gene induces overgrowth through certain growth factors such as Sonic Hedgehog which... view more... (2008-05-13)
Protein shown to play a key role in normal development of nervous system
A protein that enables nerve cells to communicate with each other plays a key role in controlling the developing nervous system. view more (2008-10-08)
New paper sheds light on bacterial cell wall recycling
A new paper by a team of researchers led by Shahriar Mobashery, Navari Family Professor of Life Sciences at the University of Notre Dame, provides important new insights into the process by which bacteria recycle their cell wall. view more (2008-09-09)
Model tissue system reveals cellular communication via amino acids
A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather than by known protein signaling agents such as growth factors or cytokines. view more (2009-04-06)
Roles of S100A2 and p63 in the carcinogenesis of esophageal squamous cell carcinoma
As a member of the S100 family, S100A2 is considered a candidate tumor-suppressor gene. Recently, p63 gene, a new member of the p53 gene family, has been studied in the fields of tumorigenesis, cell apoptosis and tissue growth. view more (2009-09-17)
How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
Many hepatocellular carcinoma (HCC) patients in China may be treated with Traditional Chinese medicine (TCM). Some say it works, others doubt its effectiveness. These stated that a research group in China had found TCM can down-regulate the expression of PTEN in HCC, which may suppress tumor cell growth and regulate tumor cell invasion and... view more... (2008-01-17)
New method to inhibit growth of tumor cells
A new and promising way to inhibit the growth of tumor cells is the result of a collaborative effort between researchers Lars-Ã"¦ke Fransson and Mattias Belting at Lund University and a team in La Jolla, USA, led by cancer researcher Jeffrey Esko. Their work involves hampering the production of two substances that help tumor cells to grow... view more... (2001-12-21)
Mayo researchers discover mechanism of cell type-specific signaling in tumor development
Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development - factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell. view more (2009-04-08)
Scientists stop colon cancer growth in mice by blocking just one enzyme
In cell culture experiments, scientists from the University of Texas Medical Branch at Galveston (UTMB) and the University of Texas at Arlington determined that stopping the activity of a single enzyme called aldose reductase could shut down the toxic network of biochemical signals that promotes inflammation and colon cancer cell growth. view more (2006-10-02)
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors
Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have been tested in clinical trials for the treatment of... view more... (2008-08-22)
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