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Novel virus entry mechanism could lead to new drugs against poxviruses
Research published in the Proceedings of the National Academy of Sciences on 11 April describes how the Imperial College London team discovered the mechanism allowing Vaccinia virus to shed its outer lipid membrane and enter cells. The mechanism is unique in virology and paves the way for... view more (2006-04-12)

Elastic interactions of membrane proteins
Cellular survival relies crucially on the ability to receive and communicate signals from and to the outside world. A major part of this regulation and communication is performed by proteins within the membrane of a cell.   view more (2007-05-04)

Heart attack in a laboratory dish
NWO researchers at Utrecht University have given heart muscle cells a heart attack in the laboratory. This allowed them to observe clearly the change that takes place in the cell membrane during an attack and how the change sometimes leads to the death of the cell. In a healthy cell, one of the... view more (2001-05-08)

Budding viral hijackers may co-opt cell machinery for the getaway
When retroviruses, like HIV, infect cells, they take over the cell's machinery to manufacture new copies of themselves. Research published this week in the top-tier open access journal, Journal of Biology, shows that to escape from cells, retroviruses may once again hijack cellular components, in... view more (2003-12-02)

Scientists at VTT and the University of Florida take immunotechnology to a new level
Scientists at VTT and the University of Florida take immunotechnology to a new level Mimicking the cell walls transport system by biocoated nanotubes opens novel possibilities for numerous applications Living cells transport selectively molecules in and out through their cell walls. This process... view more (2002-07-04)

Rong Li Lab demonstrates the process of mammalian egg maturation
he Rong Li lab team has answered an important question about how mammalian eggs undergo maturation through an intricate process of asymmetric cell division. The team discovered a novel pathway by which chromatin exerts command on the cell membrane to produce a specialized machinery used for cell... view more (2007-02-06)

Feeling up Cells
Locally resolved detection of cell signals with microelectrodes No matter how small, a living cell does not have a uniform structure. Instead, it has „organs“, called organelles, which are assigned various tasks. Even the „shell“ of the cell, its membrane, is not uniform.... view more (2001-03-01)

Gatekeeping: Penn researchers find new way to open ion channels in cell membranes
Using an enzyme found in the venom of the brown recluse spider, researchers at the University of Pennsylvania School of Medicine have discovered a new way to open molecular pores, called ion channels, in the membrane of cells.   view more (2006-07-18)

Methane bacteria possess pressure valve
Microbiologists from the University of Nijmegen have discovered that a methane-forming archaeabacterium sometimes deliberately allows hydrogen ions to leak out of its cell. At high hydrogen concentrations in particular, the cell membrane works as a sort of pressure valve. The waste of energy seems... view more (2002-10-24)

Prions link cholesterol to neurodegeneration
Prion infection of neurons increases the free cholesterol content in cell membranes. A new study published in the online open access journal BMC Biology suggests that disturbances in membrane cholesterol may be the mechanism by which prions cause neurodegeneration and could point to a role for... view more (2008-02-12)

Findings could improve fuel cell efficiency
A new type of membrane based on tiny iron particles appears to address one of the major limitations exhibited by current power-generating fuel cell technology.   view more (2008-03-20)

Targeted drug delivery now possible with 'pHLIP' peptide
Scientists at Yale and the University of Rhode Island report the development of a peptide that can specifically and directly deliver molecules to the inside of cells like a nanosyringe, creating a new tool for drug delivery, gene control and imaging of diseased tissues.   view more (2006-04-12)

Jefferson scientists uncover new clues to how crucial molecular gatekeepers work
One of the biggest mysteries in molecular biology is exactly how ion channels - tiny protein pores through which molecules such as calcium and potassium flow in and out of cells - operate.   view more (2005-10-12)

Molecular motors may speed nutrient processing
Matthew Tyska, Ph.D., recalls being intrigued, from the first day of his postdoctoral fellowship in 1999, with a nearly 30-year-old photograph. It was an electron micrograph that showed the internal structures of an intestinal cell microvillus, a finger-like protrusion on the cell surface.... view more (2007-05-31)

Researchers solve mystery of how nuclear pores duplicate before cell division
Researchers have long wondered how nuclear pores - the all-important channels that control the flow of information in and out of a cell's nucleus - double in number to prepare for the split to come when a cell divides.   view more (2006-04-21)

Protein that provides innate defense against HIV could lead to new treatments
By identifying a protein that restricts the release of HIV-1 virus from human cells, scientists believe they may be closer to identifying new approaches to treatment. The research is published in the advance online edition of Nature Medicine.   view more (2008-05-27)

£11.5m for new structural proteomics research programmes
BBSRC has announced two new research programmes that together will receive £11.5m under the Structural Proteomics of Rational Targets Initiative (SPoRT). The Membrane Protein Structure Initiative (MPSI), a consortium of experienced membrane research groups at universities and institutes... view more (2004-06-17)

Crystal structure enables tailoring of pharmaceuticals against asthma
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein - LTC4 synthase - which has a major influence on the development of asthma.   view more (2007-07-17)

Saving Cells - Safer Method for Filtering Sensitive Biological Products
For many years, engineers have worked to efficiently filter valuable bio-process products on an industrial economic scale. The challenge has been to push rates up without incurring high shear rates and resultant cell lysis, which would cause loss of yield. High shear can destroy delicate and... view more (2004-07-23)

NIST membrane model may unlock secrets of early-stage Alzheimer's
Researchers at the National Institute of Standards and Technology (NIST) and three collaborating institutions are using a new laboratory model of the membrane surrounding neurons in the brain to study how a protein long suspected of a role in early-stage Alzheimer's disease actually impairs a... view more (2008-07-24)

A balancing act between the sexes
Recent research at the European Molecular Biology Laboratory (EMBL) reveals new insights into how cells achieve equality between the sexes.   view more (2006-03-17)

Researchers reveal HIV peptide's possible pathway into the cell
Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing... view more (2008-01-18)

Semiconductor membrane mimics biological behavior of ion channels
A semiconductor membrane designed by researchers at the University of Illinois could offer more flexibility and better electrical performance than biological membranes.   view more (2007-07-13)

Researchers discover how compounds prevent viruses from entering cells
Compounds called defensins-known to prevent viruses from entering cells-appear to do so by preventing the virus from merging to cells' outer membrane.   view more (2005-09-16)

Artificial membranes can reveal biological weapons
Today there is a great need for portable equipment that can quickly detect chemical and biological weapons such as nerve gases, viruses, bacteria, and toxins.   In a new dissertation the Swedish researcher Inga Gustafsson shows that artificial membranes can be used for this purpose... view more (2004-01-16)
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