Checkpoint Gene Current Events | Checkpoint Gene News
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Protein protects anti-cancer gene from chemical shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced. view more (2007-07-20)
Researchers identify gene as protector of DNA, enemy of tumors
A single gene plays a pivotal role launching two DNA damage detection and repair pathways in the human genome, suggesting that it functions as a previously unidentified tumor suppressor gene. view more (2006-08-07)
A breakthrough in gastric carcinogenesis
Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. view more (2009-06-12)
MIT sheds light on how tumor cells form
MIT cancer researchers have discovered a process that may explain how some tumor cells form, a discovery that could one day lead to new therapies that prevent defective cells from growing and spreading. view more (2006-06-22)
Worms hold clue to link between cancer and ageing in humans
A type of protein linked to cancer prevention in humans may also play a role in ageing, according to findings published in the journal Science tomorrow. view more (2006-06-02)
A new cellular pathway linked to cancer is identified by NYU researchers
In the life of a cell, the response to DNA damage determines whether the cell is fated to pause and repair itself, commit suicide, or grow uncontrollably, a route leading to cancer. view more (2008-07-25)
Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans. view more (2005-10-17)
New research suggests a potentially damaging effect of extremely low frequency electromagnetic fields
The effect of extremely low frequency electromagnetic fields (ELF-EMF), such as those emitted around high-voltage transmission lines on human health, is controversial. Some studies suggest an association between exposure to ELF-EMF and incidence of leukaemia, although little direct evidence exists that exposure causes damage to biological... view more... (2002-07-16)
A potential approach to treatment of hepatitis B virus infection
Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. view more (2008-09-10)
Scripps research team unravels new cellular repair mechanism
The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. view more (2008-08-07)
Chromatin remodeling complex connected to DNA damage control
When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell. view more (2007-08-10)
New research finds possible genetic link to cause of pregnancy loss and disorders
Scientists at the University of Tennessee, Knoxville, and Lawrence Berkeley National Laboratory (LBNL) have published new findings about a cause of a condition at the root of genetic disorders such as Down Syndrome, pregnancy loss and infertility. view more (2009-07-22)
Chemotherapy resistance: Checkpoint protein provides armor against cancer drugs
Cell cycle checkpoints act like molecular tripwires for damaged cells, forcing them to pause and take stock. view more (2009-08-28)
Cancer stem cells linked to radiation resistance
Certain types of brain cancer cells, called cancer stem cells, help brain tumors to buffer themselves against radiation treatment by activating a "repair switch" that enables them to continue to grow unchecked. view more (2006-10-19)
Study supports DNA repair-blocker research in cancer therapy
Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves. view more (2009-08-18)
Novel connection found between biological clock and cancer
Dartmouth Medical School geneticists have discovered that DNA damage resets the cellular circadian clock, suggesting links among circadian timing, the cycle of cell division, and the propensity for cancer. view more (2006-06-30)
Research sheds light on cause of Down syndrome and other genetic disorders
Scientists have a better understanding of what causes an abnormal number of chromosomes in offspring, a condition called aneuploidy that encompasses the most common genetic disorders in humans, such as Down syndrome, and is a leading cause of pregnancy loss. view more (2009-07-20)
Researchers find how a common genetic mutation makes cancer radiation resistant
Many cancerous tumors possess a genetic mutation that disables a tumor suppressor called PTEN. Now researchers at Washington University School of Medicine in St. Louis have shown why inactivation of PTEN allows tumors to resist radiation therapy. view more (2009-06-10)
Columbia University Medical Center researchers discover potential mechanism for tumor growth
Researchers at Columbia University Medical Center have identified an inherent feature of stem and progenitor cells that may promote initiation and progression of cancerous tumors. view more (2005-12-16)
Gene-transcription machinery seen poised for action, held in check until needed
For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes. view more (2007-07-26)
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