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Rong Li Lab demonstrates the process of mammalian egg maturation
he Rong Li lab team has answered an important question about how mammalian eggs undergo maturation through an intricate process of asymmetric cell division. The team discovered a novel pathway by which chromatin exerts command on the cell membrane to produce a specialized machinery used for cell division. view more (2007-02-06)
Chromatin remodeling complex connected to DNA damage control
When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell. view more (2007-08-10)
BRIT1 allows DNA repair teams access to damaged sites
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access. view more (2009-06-22)
Mapping dynamic Polycomb group proteins during Drosophila development
The developmental passage from a ball of cells to a fruit-fly is a very complicated process involving both temporal and spatial regulation of genes and pathways. view more (2006-04-20)
Selfing DNA prevents genomes from mixing
Genomes of multicellular organisms are one of the greatest mysteries of biology. The more is discovered about them, the more questions are to be answered. One of such questions is connected with the size of a genome. As is known since the middle of the 20th century, the level of organization of an organism does not depend on the genome size, i.e.,... view more... (2002-10-11)
Roles of DNA packaging protein revealed by Einstein scientists
Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a class of chromatin proteins is crucial for maintaining the structure and function of chromosomes and the normal development of eukaryotic organisms. view more (2009-02-13)
Raising the alarm when DNA goes bad
Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. view more (2009-08-14)
New technique yields more detailed picture of chromatin structure
University of Illinois researchers have developed a technique for imaging cells under an electron microscope that yields a sharper image of the structure of chromatin, the tightly wound bundle of genetic material and proteins that makes up the chromosomes. view more (2008-04-17)
UVa-led team uncovers important secret in gene replication
A team of researchers led by University of Virginia Health System geneticists has uncovered a major secret in the mystery of how the DNA helix replicates itself time after time. view more (2007-06-14)
SUMO protein guides chromatin remodeler to suppress genes
In an in vitro study, led by Grace Gill, PhD, Tufts University School of Medicine, researchers discovered how a protein called SUMO (Small Ubiquitin-related Modifier) guides an enzyme complex that alters the structure of chromatin to regulate expression of genes. view more (2009-04-28)
Once suspect protein found to promote DNA repair, prevent cancer
An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science. view more (2008-07-22)
Opening and closing the genome
At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. view more (2007-02-26)
Genomatix integrates genome-wide open chromatin from next generation sequencing
Genomatix Software GmbH, a Systems Biology company focussed on high quality annotation and the understanding of gene regulation, has begun showcasing its abilities in the analysis of data generated by Next Generation Sequencing (NGS) technology. view more (2008-02-26)
LincRNAs serve as genetic air-traffic controllers
Earlier this year, a scientific team from Beth Israel Deaconess Medical Center (BIDMC) and the Broad Institute identified a class of RNA genes known as large intervening non-coding RNAs or "lincRNAs," a discovery that has pushed the field forward in understanding the roles of these molecules in many biological processes, including stem... view more... (2009-07-15)
Novel molecular 'signature' marks DNA of embryonic stem cells
A team of scientists announced today a critical step on the path of realizing the promise of embryonic stem (ES) cells for medicine. view more (2006-04-21)
Ali Shilatifard and Colleagues Aim to Clarify the Definition of "Epigenetics"
Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" - a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence. view more (2009-04-02)
'Insulator' helps silence genes in dormant herpes virus
By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. view more (2007-05-03)
Breast cancer : Discovery of a new tumor marker
At the Curie Institute in Paris, CNRS researchers have discovered a new proliferation marker : the CAF-1 complex. Since deregulated cell proliferation is one of the most characteristic features of tumor cells, this discovery represents a breakthrough in the cancer field. The researchers from the Curie Institute have already validated the use of... view more... (2004-03-30)
HIRA, a new factor in the genome's 3D organizational assembly chain
At the heart of every cell, vital information is "written" on the DNA, a long molecular ribbon almost one meter long bundled inside the nucleus of the cell. For the DNA to fit inside this small space, it is rolled up like a ball of yarn in a highly organized structure called chromatin. Beyond its purely structural role, the spatial... view more... (2002-06-05)
Gerton Lab determines the composition of centromeric chromatin
The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell. view more (2009-09-29)
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