Chromatin Current Events | Chromatin News | 2
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MIT-led team IDs gene key to Alzheimer's-like reversal
A team led by researchers at MIT's Picower Institute for Learning and Memory has now pinpointed the exact gene responsible for a 2007 breakthrough in which mice with symptoms of Alzheimer's disease regained long-term memories and the ability to learn. view more (2009-05-07)
Delving deeper into the machinery of cocaine addiction
Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery. view more (2005-10-20)
CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments
The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end. A genome of this size can squeeze into a cell's tiny nucleus because it is compressed into highly condensed chromatin fibers by proteins called histones. view more (2009-04-10)
Conaway Lab Identifies Novel Mechanism for Regulation of Gene Expression
The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell. view more (2008-09-29)
Conaway Lab uncovers function of potential cancer-causing gene product
The Stowers Institute's Conaway Lab has uncovered a previously unknown function of a gene product called Amplified in Liver Cancer 1 (Alc1), which may play a role in the onset of cancer. view more (2009-08-10)
Molecular partners required for appropriate neuronal gene repression
In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems. view more (2005-08-04)
How embryonic stem cells maintain their identity
Two studies in the April 21, 2006 Cell report new details of the "genetic program" that affords embryonic stem cells the flexibility to give rise to any cell type in the body. view more (2006-04-21)
Brain DNA 'remodeled' in alcoholism
Reshaping of the DNA scaffolding that supports and controls the expression of genes in the brain may play a major role in the alcohol withdrawal symptoms, particularly anxiety, that make it so difficult for alcoholics to stop using alcohol. view more (2008-04-02)
Cold Spring Harbor Protocols features methods for visualizing protein dynamics
This month's release of Cold Spring Harbor Protocols highlights methods that permit scientists to observe protein dynamics in chromosomes and embryos. view more (2008-01-03)
University of Washington researchers play leading role in major study of human genome function
Scientists at the University of Washington and other members of an international consortium have completed a multi-year research effort that dramatically boosts understanding of how the human genome functions. view more (2007-06-14)
Conaway Lab Demonstrates Mechanism by which Transcription Factor Controls Gene Expression
The Conaway Lab - led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators - has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression. Yong Cai, Ph.D., Research Specialist I, and Jingji Jin, Ph.D., Senior Research Associate, are the paper's coequal first authors. view more (2007-08-28)
Gene packaging tells story of cancer development
To decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging. view more (2008-12-05)
Computation to unravel how genes are regulated and shed light on how cells become different
A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression. view more (2008-04-11)
Effects of aging in stem cells
There is little disagreement that the body's maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why. view more (2007-07-24)
Proteasome inhibition affects epigenetic mechanisms
Alcohol consumption causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunoresponse defect, and fibrosis. view more (2009-02-19)
EuroDYNA takes lid off the genome
European researchers have made significant progress unravelling how genes are governed and why this sometimes goes wrong in disease. view more (2008-06-16)
'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Tumor cells living in the cross hairs of radiation or chemotherapy may be able to escape death because their self-destruct mechanisms are jammed, say University of Florida scientists writing in a recent issue of Developmental Cell. view more (2008-05-01)
Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm
In higher order animals, genetic information is passed from parents to offspring via sperm or eggs, also known as gametes. In some single-celled organisms, such as yeast, the genes can be passed to the next generation in spores. view more (2006-09-18)
Controlling embryonic fate by association
Association determines fate in embryonic stem cells, said Baylor College of Medicine researchers in a report that appears in the current issue of the journal Nature Cell Biology. view more (2008-05-05)
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex
The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell. view more (2008-12-08)
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