Chromosomal Instability Current Events | Chromosomal Instability News
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'Signature' of chromosome instability predicts cancer outcomes
Microscopic examination of tumor specimens cannot always predict a cancer's aggressiveness, leading to increased interest in molecular approaches to diagnosis. view more (2006-08-21)
Chromosomes tell tale of patient's risk for new, future cancer
Hodgkin's disease survivors who have greater genetic instability in their white blood cells are two-and-a-half times more likely to develop another type of cancer. view more (2007-04-17)
Proximity To Landfill Sites Linked To Increased Risk Of Congenital Chromosomal Abnormalities (p 320)
New data from a 1998 study to assess the potential risks of chromosomal abnormalities of residents living near landfill sites is detailed in a research letter in this week's issue of THE LANCET. The findings suggest that the increased risk of chromosomal abnormalities is of a similar magnitude to the increased risk of non-chromosomal abnormalities... view more... (2002-01-23)
Researchers identify gene as protector of DNA, enemy of tumors
A single gene plays a pivotal role launching two DNA damage detection and repair pathways in the human genome, suggesting that it functions as a previously unidentified tumor suppressor gene. view more (2006-08-07)
The downside to diversification
Dr. Dale Ramsden and colleagues at UNC-Chapel Hill report in the June 15th issue of G&D on the potential contribution of V(D)J recombination to genomic instability and cancer formation. view more (2006-06-15)
Chromosomal problems affect nearly all human embryos
For the first time, scientists have shown that chromosomal abnormalities are present in more than 90% of IVF embryos, even those produced by young, fertile couples. view more (2009-07-01)
Link unraveled between chromosomal instability and centrosome defects in cancer cells
In a new study, Dana-Farber Cancer Institute scientists disprove a century-old theory about why cancer cells often have too many or too few chromosomes, and show that the actual reason may hold the key to a novel approach to cancer therapy. view more (2009-06-08)
Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening
Embryos that are selected out as abnormal can undergo chromosomal modifications, a scientist will tell the annual conference of the European Society of Human Genetics today. view more (2007-06-19)
Chromosomal microarray analysis proves accurate
Two years and more than 2,000 samples after researchers at Baylor College of Medicine started to use a new gene-chip technology called chromosomal microarray analysis to look for potential genetic abnormalities in children, they find that it is remarkably sensitive in detecting abnormalities in individual chromosomes. view more (2007-03-30)
Discovery may result in new test to determine predisposition to cancer
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed an assay that may be used to help identify new genes that can predict a predisposition to cancer. view more (2009-03-25)
New gene associated with Fanconi anemia 'explains' hallmark chromosomal instability
Surprising findings from just five patients has led to the first proof of how the rare disorder Fanconi anemia causes chromosomal instability. view more (2005-08-22)
Little known DNA repair enzyme may be a tumor suppressor gene
The DNA in our cells is constantly being bombarded by environmental, chemical and cellular insults. Fortunately, our cells contain many enzymes devoted strictly to detecting and repairing any damage caused by these insults. view more (2006-01-04)
Baumann Lab demonstrates role of protein in distinguishing chromosome ends from DNA breaks
The Stowers Institute's Baumann Lab has demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. view more (2009-09-18)
Caesar researchers discover a mechanism in the pathogenesis of breast cancer
New approaches in breast cancer therapy view more (2005-05-17)
MicroRNAs as tumor suppressors
In the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro. view more (2007-04-16)
Bacteria change 'fingerprints' and baffle detectives
Tracing the source of a campylobacter food poisoning outbreak can be very difficult even with modern DNA fingerprinting methods. There is now evidence that campylobacters can rearrange their DNA, disguising their fingerprint, and confusing such detective work, scientists heard today (Tuesday 09 April 2002) at the spring meeting of the Society for... view more... (2002-04-02)
Mathematics reveals genetic pattern of tumor growth
Using mathematical theory, UC Irvine scientists have shed light on one of cancer's most troubling puzzles - how cancer cells can alter their own genetic makeup to accelerate tumor growth. view more (2007-06-25)
Ultrasound Detection of Down Syndrome
New Method Shown to be Effective for Detecting Down Syndrome at Mid-Trimester Scan Looking at the nasal bones of fetuses at the mid-trimester scan could improve the detection of Down Syndrome during pregnancy, according to results to be published in the January 2003 issue of Ultrasound in Obstetrics & Gynecology, the official journal of the... view more... (2002-12-12)
USC researchers identify key mechanism that occurs at the inception point of many human lymphomas
Researchers at the Keck School of Medicine of the University of Southern California (USC) have explained how certain key mutations occur in human lymphomas-a process that has, until now, remained a mystery. view more (2008-12-12)
PGD could save women from the agony of repeated miscarriages
Women who suffer repeated unexplained miscarriages can be helped to have babies if preimplantation genetic diagnosis (PGD) is carried out on their embryos before they are placed in the womb. Ms Carmen Rubio told the European Society of Human Reproduction and Embryology annual conference in Vienna today (Monday 1 July) that her research showed that... view more... (2002-06-29)
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