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Temperature sensing by the circadian clock
In the September 1 issue of G&D, Dr. Michael Brunner and colleagues have uncovered the molecular mechanism whereby temperature affects circadian patterns in the fungus Neurospora.   view more (2005-08-17)

Scientists unravel the molecular basis of monarch butterfly migration
Since its discovery, the annual migration of eastern North American monarch butterfly has captivated the human imagination and spirit. That millions of butterflies annually fly up to 2000 miles to reach a cluster of pine groves in central Mexico comprising just 70 square miles is for many an awesome and mysterious occurrence.   view more (2008-01-09)

The food-energy cellular connection revealed
Our body's activity levels fall and rise to the beat of our internal drums-the 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the energy available to our cells.   view more (2009-10-16)

UNC study supports role of circadian clock in response to chemotherapy
For years, research has hinted that the time of day that cancer patients receive chemotherapy can impact their chances of survival. But the lack of a clear scientific explanation for this finding has kept clinicians from considering timing as a factor in treatment.   view more (2009-01-13)

A Biological Basis for the 8-Hour Workday?
The circadian clock coordinates physiological and behavioral processes on a 24-hour rhythm, allowing animals to anticipate changes in their environment and prepare accordingly. Scientists already know that some genes are controlled by the clock and are turned on only one time during each 24-hour cycle.   view more (2009-04-24)

Central and peripheral signals set the circadian liver clock
Anyone who has experienced jet lag will understand the importance of a smooth-running circadian clock. Crossing time zones decouples our biological rhythms from the natural cycle of light and dark we're used to.   view more (2007-01-30)

Light-induced hormone surge points to benefits of light therapy
A report in the November Cell Metabolism reveals powerful effects of light on the adrenal glands, a finding that might explain the broad benefits of bright light therapy for a variety of conditions, including sleep and depressive disorders, according to researchers.   view more (2005-11-09)

Scripps research scientists model 3D structures of proteins that control human clock
In an Early Edition issue of The Proceedings of the National Academy of Sciences (PNAS) on April 9, 2009, the researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surprisingly similar to two cryptochrome proteins that control the "master clock" in humans and other mammals.   view more (2009-04-13)

U-M discovery about biological clocks overturns long-held theory
University of Michigan mathematicians and their British colleagues say they have identified the signal that the brain sends to the rest of the body to control biological rhythms, a finding that overturns a long-held theory about our internal clock.   view more (2009-10-09)

Pain and stiffness intensity ebb and flow according to body clock in osteoarthritic patients
Levels of pain intensity and arthritic stiffness closely follow the rhythms of the body clock, reveals research in the Annals of the Rheumatic Diseases.   view more (2002-11-12)

Scientists reveal new pattern in our daily clock
The findings of a study published in Science today turn a long-held theory on circadian rhythms on its head and mean that we may now be able to develop new drugs and approaches to tune the daily clock to treat sleep disorders and to aid recovery from long-distance flights.   view more (2009-10-09)

Optical Atomic Clock: A long look at the captured atoms
Optical clocks might become the atomic clocks of the future. Their "pendulum", i.e. the regular oscillation process which each clock needs, is an oscillation in the range of the visible light.   view more (2008-02-06)

Cicardian system suffers and protects from prenatal cocaine exposure
Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.   view more (2007-07-11)

Travelers can avoid jet lag by resetting their body clocks
A simple, at-home treatment - a single light box and the over-the-counter drug melatonin - allows travelers to avoid jet lag by resetting their circadian body clock before crossing several time zones.   view more (2005-11-02)

Biologists find biological clock for smell in mice
Biologists at Washington University in St. Louis have discovered a large biological clock in the smelling center of mice brains and have revealed that the sense of smell for mice is stronger at night, peaking in evening hours and waning during day light hours.   view more (2006-12-19)

Gene that makes people 'early to bed and early to rise' demystified
The recent discovery that a mutant "clock" gene made some people "early to bed and early to rise," a condition known as familial advanced sleep phase syndrome (FASPS), offered one of the first glimpses into the genetic basis of sleep in humans.   view more (2007-01-12)

Protein shown to rally biological clock
A biologist at Washington University in St. Louis and his collaborators have identified the factor in mammalian brain cells that keeps cells in synchrony so that functions like the wake-sleep cycle, hormone secretion and loco motor behaviors are coordinated daily over a 24-hour period.   view more (2006-11-30)

New sleep gene discovery wakes up scientists
Proteins that regulate sleep and biological timing in the body work much differently than previously thought, meaning drug makers must change their approach to making drugs for sleep disorders and depression and other timing-related illnesses.   view more (2006-07-05)

Texas A&M researchers find new mechanism for circadian rhythm
Molecules that may hold the key to new ways to fight cancer and other diseases have been found to play an important role in regulating circadian rhythm, says Liheng Shi, a researcher in Texas A&M's Department of Veterinary Integrative Biosciences.   view more (2009-10-21)

WUSTL research finds individual cells isolated from the biological clock can keep daily time, but are unreliable
Alexis Webb enters a small room at Washington University in St. Louis with walls, floor and ceiling painted dark green, shuts the door, turns off the lights and bends over a microscope in a black box draped with black cloth. Through the microscope, she can see a single nerve cell on a glass cover slip glowing dimly.    view more (2009-09-10)
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