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Novel connection found between biological clock and cancer
Dartmouth Medical School geneticists have discovered that DNA damage resets the cellular circadian clock, suggesting links among circadian timing, the cycle of cell division, and the propensity for cancer. view more (2006-06-30)
Genes linked to daily flux in drug toxicity
New findings in the July, 2006, Cell Metabolism, published by Cell Press, may help to explain daily fluctuations in the ability to detoxify chemical substances, including chemotherapy drugs and sedatives. view more (2006-07-06)
Clock molecule's sensitivity to lithium sheds light on bipolar disorder
Researchers at the University of Pennsylvania School of Medicine discovered that a key receptor protein is a critical component of the internal molecular clock in mammals. What's more, this molecule -called Rev-erb- is sensitive to lithium and may help shed light on circadian rhythm disorders, including bipolar disorder. view more (2006-02-17)
Light-induced hormone surge points to benefits of light therapy
A report in the November Cell Metabolism reveals powerful effects of light on the adrenal glands, a finding that might explain the broad benefits of bright light therapy for a variety of conditions, including sleep and depressive disorders, according to researchers. view more (2005-11-09)
Missing or mutated 'clock' gene linked to vascular disease
The circadian clocks that set the rhythmic motion of our bodies for wakeful days and sleepy nights can also set us up for vascular disease when broken, Medical College of Georgia researchers say. view more (2009-03-26)
Better sleep may put Huntington's disease sufferers back on track
Mice carrying the genetic mutation that causes Huntington's Disease (HD) showed marked improvements in alertness and their ability to learn after they were given drugs that put them to sleep. view more (2007-07-18)
Simplest circadian clocks operate via orderly phosphate transfers
Researchers at Harvard University and the Howard Hughes Medical Institute have found that a simple circadian clock found in some bacteria operates by the rhythmic addition and subtraction of phosphate groups at two key locations on a single protein. view more (2007-10-05)
First molecular evidence of body's internal clock in controlling blood pressure
It has been known for decades that heart attacks and strokes occur most frequently in the early-morning hours. Now, researchers at the University of Pennsylvania School of Medicine have provided the first evidence for the role of our body's internal molecular clock in controlling blood pressure and a mechanism by which this occurs. view more (2007-02-20)
Keeping the body in sync — The stability of cellular clocks
A study in Switzerland uses the tools of physics to show how our circadian clocks manage to keep accurate time in the noisy cellular environment. view more (2007-03-13)
Melatonin improves mood in winter depression
Researchers at Oregon Health & Science University(OHSU) have found that melatonin, a naturally occurring brain substance, can relieve the doldrums of winter depression, also known as seasonal affective disorder, or SAD. view more (2006-05-02)
Chemotherapy for breast cancer is associated with disruption of sleep-wake rhythm in women
A study in the Sept.1 issue of the journal Sleep shows that the sleep-wake activity rhythms of breast cancer patients are impaired during the administration of chemotherapy. view more (2009-09-01)
Multitasking is hardest in the early morning
Multitasking seems to come easier for some and is virtually impossible for others, however new research shows that it is difficult for all in the late night and early morning. view more (2007-05-07)
Feeling sleepy is all in your genes
Genes responsible for our 24 hour body clock influence not only the timing of sleep, but also appear to be central to the actual restorative process of sleep, according to research published in the online open access journal BMC Neuroscience. view more (2007-10-18)
Mood Lighting: Penn Researchers Determine Role of Serotonin in Modulating Circadian Rhythm
Researchers at the University of Pennsylvania School of Medicine have determined how serotonin decreases the body's sensitivity to light and that exposure to constant darkness leads to a decrease in serotonin levels in the brain of fruit flies. view more (2005-07-11)
ESC Congress 2003: Spirolactone may normalize the circadian non-dipper blood pressure rhythm in salt-sensitive black hypertensives
IMPORTANT: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology ESC Congress 2003: We have shown that spironolactone (a drug that is able to antagonise the effects of... view more... (2003-09-02)
Prenatal alcohol exposure can alter circadian rhythms in offspring
Children with fetal alcohol spectrum disorders (FASD) suffer from a variety of behavioral alterations. For example, they may exhibit alterations in sleeping and eating patterns, which may indicate that their circadian systems - which control biological rhythms - have been affected by alcohol exposure during development. view more (2006-04-24)
Genetic pathway responsible for link between body clock disturbance and worsening arthritis
The genes that regulate human circadian rhythm, or 'the body clock', are significantly disturbed in individuals with arthritis. view more (2009-06-11)
NYU dental professor discovers biological clock
Why do rats live faster and die younger than humans? A newly discovered biological clock provides tantalizing clues. view more (2008-04-07)
New sleep gene discovery wakes up scientists
Proteins that regulate sleep and biological timing in the body work much differently than previously thought, meaning drug makers must change their approach to making drugs for sleep disorders and depression and other timing-related illnesses. view more (2006-07-05)
Phase of clock gene expression in human leukocytes correlates with habitual sleep timing
The phase of clock gene expression in leukocytes, assessed in the absence of the masking effects of light-dark and sleep-wake cycles, correlates with habitual sleep timing, according to a study published in the May 1 issue of the journal SLEEP. view more (2008-05-01)
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