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Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine
Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors (PPIs), did not lead to adverse events, as some prior studies had suggested. view more (2009-09-25)
How effective are opioids in chronic pain relief?
Fentanyl skin patches achieve better pain relief and an enhanced quality of life than sustained release oral morphine, say patients with chronic non-cancer pain in a study in this week's BMJ. Patients with chronic non-cancer pain, requiring continuous treatment with potent opioids, were randomly assigned to two groups to assess their treatment... view more... (2001-05-09)
Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues
The Ludwig Institute for Cancer Research (LICR) and Life Science Pharmaceuticals (LSP) today announced the results of the first clinical trial of monoclonal antibody (mAb) 806, which demonstrate that 806 specifically targets epidermal growth factor receptor (EGFR) on a wide range of tumor types but has no uptake by normal tissues. view more (2006-06-06)
New study challenges NICE guidelines on adolescent depression
Should adolescents with depression be prescribed antidepressants, and if so, should they be given only with a psychological therapy, as advocated by the National Institute for Health and Clinical Excellence (NICE)" view more (2007-07-20)
Clinical trial in China to test whether early blood pressure reduction improves stroke outcomes
A large clinical trial called INTERACT, launched in China this month, will determine the effects of early intensive blood pressure lowering on death and disability in stroke patients. view more (2005-11-01)
Children's national co-leads nationwide study of landmark sickle cell treatment
Children's National Medical Center immunologist and blood and marrow transplant physician Naynesh Kamani, MD, will serve as the study co-chair for a new national clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease. view more (2008-08-19)
Analysis shows that vidaza prolongs survival in patients with higher-risk myelodysplastic syndromes
The Myelodysplastic Syndromes (MDS) Foundation announced today that a subanalysis of the AZA-001 phase III international clinical trial shows that treatment with VIDAZA (azacitidine) can extend overall survival and reduce the risk of death in elderly higher-risk MDS patients. view more (2008-12-11)
Negative Newspaper Articles about Clinical Trials Decrease Public Willingness to Participate, Study Finds
A University of Missouri-Columbia study has found that newspapers' front page and section stories about clinical trials are overwhelmingly negative and that exposure to these stories may decrease people's willingness to participate in medical trials. view more (2007-03-21)
Multiple myeloma clinical trial closes early
Mayo Clinic Cancer Center announced today that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone. view more (2007-04-05)
Current Controlled Trials' numbering scheme is adopted by CHIR
Dr. Alan Bernstein, President of the Canadian Institutes of Health Research (CIHR), announced today a new randomized controlled trial policy that will require all CIHR funded clinical trials to register with an International Standard Randomised Controlled Trial Number (ISRCTN). The goal of the policy is to help ensure clinicians, researchers,... view more... (2004-07-23)
Second TroVax Phase I/II trial results presented at the 94th annual meeting of the American Association for Cancer Research
Oxford, UK: 14 July 2003 - Oxford BioMedica announced today that it is presenting new clinical data on the Company's lead cancer product, TroVax®, at the American Association for Cancer Research (AACR) Annual Meeting in Washington, DC. The results are being presented by Dr. Richard Harrop, Principal Scientist at Oxford BioMedica. Following on... view more... (2003-07-14)
Can an omega-3 fatty acid slow the progression of Alzheimer's disease?
Nutritionists have long endorsed fish as part of a heart-healthy diet, and now some studies suggest that omega-3 fatty acids found in the oil of certain fish may also benefit the brain by lowering the risk of Alzheimer's disease. view more (2007-05-11)
Chemotherapy trial proves the worth of including elderly patients in clinical trials
Doctors should be encouraged to include many more elderly people in clinical trials than they do at present, Dr Olavo Feher told the 3rd European Breast Cancer Conference in Barcelona today (Wednesday 20 March). Dr Feher, attending physician at the Hospital do Cancer in Sao Paulo, Brazil, said that the elderly were under-represented in clinical... view more... (2002-03-18)
Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia
An established second-line drug for chronic myelogenous leukemia has high response rates when given to newly diagnosed patients as their first therapy for the disease, according to early results from a Phase II clinical trial at The University of Texas M. D. Anderson Cancer Center. view more (2007-06-04)
New drug combination shows promise for African sleeping sickness
A small clinical trial in Uganda, conducted within a long-established Médecins Sans Frontières (MSF) treatment program for African sleeping sickness, has found that a new combination treatment using the drugs nifurtimox and eflornithine holds promise and deserves further evaluation. view more (2007-11-07)
National call for cancer clinical trial system to be more responsive to community needs
Addressing the nation's continuing poor performance in cancer clinical trial participation, particularly among racial and ethnic minorities and low income groups, will require meaningful public involvement in the design and implementation of clinical trials, according to a landmark report released today. view more (2008-11-11)
Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients
Previously untreated non-small cell lung cancer (NSCLC) patients over the age of 70 respond well to a combination of bevacizumab and erlotinib, Fox Chase Cancer Center researchers reported today at the annual meeting of the International Association for the Study of Lung Cancer. view more (2009-08-03)
Therapeutic vaccine for ovarian cancer in clinical trials
Prima BioMed (ASX: PRR) announced today at the "Thank You" Day celebration at Sydney Children's Hospital that it has completed initial recruitment of its Phase IIa clinical trial in ovarian cancer at the Austin Hospital. view more (2005-10-12)
No benefit to "nil by mouth" after surgery
There is no benefit in keeping patients "nil by mouth" (a period of starvation) after gastrointestinal surgery, suggests a study in this week's BMJ. These findings should challenge doctors to consider starting early feeding in these patients. Eleven trials comparing enteral (tube) feeding within 24 hours after surgery with nil by mouth... view more... (2001-10-03)
Clinical trial for diabetic macular edema
he Juvenile Diabetes Research Foundation, the world's largest charitable funder of type 1 diabetes research, announced that the Ranibizumab for Edema of the mAcula in Diabetes Phase 2 Study (READ 2) is now enrolling patients. view more (2007-03-27)
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