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Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer Mayo Clinic today reported promising interim results from a Phase II trial of a new combination therapy for patients with recurrent ovarian cancer that is resistant to platinum therapy. Thirty-three percent of study participants achieved either complete or partial tumor regression from the therapy, which combines flavopiridol and cisplatin. view more (2007-10-24)
ASTRO issues consensus statement on using APBI to treat breast cancer The American Society for Radiation Oncology has published a consensus statement outlining patient selection criteria and best practices for the use of accelerated partial breast irradiation (APBI) outside the context of a clinical trial. view more (2009-07-15)
UTMB researchers test new vaccine to fight multiple influenza strains A universal vaccine effective against several strains of influenza has passed its first phase of testing, according to Dr. Christine Turley of the University of Texas at Galveston. view more (2008-08-22)
Undisclosed payments to doctors recruiting trial patients is unethical Doctors are often paid to recruit patients to clinical trials sponsored by pharmaceutical companies, yet such payments are often not disclosed to the patients. Researchers in this week`s BMJ argue that this practice is unethical and damages efforts to involve patients more fully in clinical trials. Over the years, payments have soared to thousands... view more... (2002-07-03)
New form of intravenous iron treats anemia in chronic kidney disease patients on dialysis Ferumoxytol, a novel intravenous form of iron that permits rapid administration of large doses, has been shown to be effective for treating iron deficiency in chronic kidney disease (CKD) patients on dialysis, according to a clinical trial appearing in the February 2009 issue of the Clinical Journal of the American Society Nephrology (CJASN). view more (2009-01-28)
Vioxx trial data shows early cardiovascular risk Evidence of cardiovascular risks associated with taking Vioxx, the popular, nonsteroidal anti-inflammatory drug (rofecoxib), could have been identified nearly four years before its manufacturer, Merck & Co. Inc., voluntarily pulled the drug from the market. view more (2009-11-24)
Knowing doctor's financial interests doesn't deter clinical trial participants A patient's willingness to participate in a clinical trial may be unaffected by the disclosure of a researcher's financial interests in the study, unless the amount of money a researcher stands to earn depends on the results of the trial, according to a new study by researchers at the Duke Clinical Research Institute (DCRI), Wake Forest... view more... (2008-04-03)
Drug shows promise against advanced form of lung cancer Results of a multi-center clinical study of a drug currently approved for treatment of kidney cancer indicate that it may also be effective for people with recurrent and advanced lung cancer. view more (2006-06-05)
Breast tenderness during hormone replacement therapy linked to elevated cancer risk Women who developed new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy were at significantly higher risk for developing breast cancer than women on the combination therapy who didn't experience such tenderness, according to a new UCLA study. view more (2009-10-13)
First clinical trial of intravenous rViscumin under way in Germany and France Frankfurt, Germany: More than 30 patients in Germany and France with a variety of drug resistant cancers have so far been recruited to a phase I study of rViscumin, a recombinant E.coli-derived protein with a structural similarity to mistletoe lectin I - a component of natural mistletoe extracts from Viscum album. But, a news briefing (Thursday... view more... (2002-11-17)
Green tea extract shows promise in leukemia trials Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea. view more (2009-05-27)
Milestone for cannabinoid MS study The CUPID (Cannabinoid Use in Progressive Inflammatory brain Disease) study at the Peninsula Medical School in Plymouth has reached an important milestone with the news that the full cohort of 493 people with multiple sclerosis (MS) has been recruited to the study. view more (2008-07-22)
Adding ultrasound screening to mammography brings benefits, risks Adding a screening ultrasound examination to routine mammography reveals more breast cancers than mammography alone, according to results of a major new clinical trial. The trial, however, also found that adding an ultrasound exam also increases the rate of false positive findings and unnecessary biopsies. view more (2008-05-14)
Drug-eluting stents more effective, equally as safe as bare metal stents in clinical trial Late-breaking data from the HORIZONS AMI (Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction) trial reveal that after one year, use of a drug-eluting (paclitaxel) stent demonstrated significantly reduced rates of target lesion revascularization (TLR) and binary angiographic restenosis when compared to the use of... view more... (2008-10-16)
Widely-Used Treatment For Head Injuries Found To Be Harmful (pp 1291, 1321) The use of anti-inflammatory drugs to treat patients with severe head injuries-common practice worldwide for the past 30 years-is actually dangerous and associated with around a 20% increase in death within two weeks of hospital admission, conclude authors of an international study in this week's issue of THE LANCET. view more (2004-10-06)
Neonatal trials - asking the right questions Gaining consent from parents on behalf of their children for neonatal trials - where new treatments are tested on new-born, ill babies - is often asked for and given inappropriately, Leeds research has shown. Dr Su Mason from the clinical trials and research unit interviewed 200 parents from nine European countries and found that in two-thirds of... view more... (2004-02-23)
Greater transparency for clinical trials Launch of the first international clinical trial numbering scheme Current Controlled Trials Ltd today announced the launch of the International Standard Randomised Controlled Trial Number (ISRCTN) Register. The ISRCTN Register represents the first online service that provides unique numbers to randomised controlled trials in all areas of health... view more... (2003-05-16)
First human gets new antibody aimed at hepatitis C virus Building upon a series of successful preclinical studies, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed that can neutralize the Hepatitis C virus (HCV). view more (2009-08-07)
Ways to improve informed consent are testable, study says New ways to make sure people are adequately informed about the risks and benefits of taking part in a clinical trial can be field-tested for effectiveness as vigorously as new medical treatments themselves, a study led by a Johns Hopkins bioethicist suggests. view more (2008-01-14)
The Lancet publishes first clinical trial data of a fully bioabsorbable drug eluting stent Data published today in The Lancet from ABSORB, the world's first clinical trial of a fully bioabsorbable drug eluting stent for the treatment of coronary artery disease, demonstrated no stent thrombosis, no clinically driven target lesion revascularizations (re-treatment of a diseased lesion), and a low (3.3 percent) rate of major adverse cardiac... view more... (2008-03-14)
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