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New anti-blood-thinning drug not as safe as protamine
The results of an international clinical trial led by Duke University Medical Center researchers has shown that a new drug is not a suitable replacement for protamine, a drug that has been used for more than 40 years after coronary artery bypass surgery to return thinned blood to its normal state. view more (2005-08-01)
Cancer study finds adolescents don't get same access to latest treatments as younger patients
The overall survival rate from cancer now is lower in older adolescents and young adults with cancer than in younger children, in part because of a lack of access to clinical trials nationally for the older age group. view more (2008-01-16)
OBESITY DRUG COULD SUSTAIN WEIGHT LOSS (p 2119)
Results of a clinical trial published in this week's issue of THE LANCET suggest that the drug sibutramine is effective in sustaining weight loss in obese patients. However, questions remain about the drug's long-term safety. Sibutramine is a tertiary amine, originally developed as a potential antidepressant. It has been shown to induce... view more... (2000-12-21)
Lenalidomide safe as single therapy for elderly CLL patients
The oral medication lenalidomide is safe and well-tolerated for elderly patients with chronic lymphocytic leukemia, a group without a well-defined frontline therapy for their disease, researchers from The University of Texas M. D. Anderson Cancer Center reported today at the 50th annual meeting of the American Society of Hematology. view more (2008-12-08)
Pharmaceutical market fails pregnant women; and more
In a clinical trial published this week in PLoS Medicine, Charles Sawyers and colleagues looked at the safety of a drug called rapamycin in a selected group of patients who were undergoingsurgery after recurrence of glioblastoma (a highly malignant tumor of the brain). view more (2008-01-22)
Concerns raised over policy to add folic acid to flour
A UK Department of Health committee has now recommended universal fortification of flour with folic acid to reduce the level of neural tube defects. Yet researchers in this week's BMJ warn that we need to be cautious before introducing such a policy. Although the benefits of supplementation are clear, the possible harms of such a policy are not,... view more... (2001-11-20)
ESC Congress 2004: Antibiotic Treatment for Secondary Prevention of Coronary Events: Results of the Azithromycin and Coronary Events Study (ACES)
Results of large-scale clinical trial of antibiotic treatment to reduce heart attacks view more (2004-08-30)
New drugs boost for asbestos-related lung cancer sufferers
Clinical trials of a new anticancer drug combination carried out by researchers at Newcastle University show that it has potential to almost double the life expectancy of sufferers of Mesothelioma - a form of lung cancer which affects around 1,700 people in the UK every year - according to a report published in the Journal of Clinical Oncology.... view more... (2002-08-12)
Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer
Henry Ford Hospital is embarking on an expanded major clinical trial involving the use of gene therapy in combination with radiation therapy, to determine if the combined treatment is more effective than radiation therapy alone for patients with intermediate risk prostate cancer. view more (2008-02-07)
Analysis shows combining sorafenib with carboplatin/paclitaxel adds no benefit in lung cancer
A clinical trial evaluating the benefit of adding the drug sorafenib to the combination of carboplatin/paclitaxel chemotherapy for lung cancer patients has been stopped based on results from an interim analysis, after an independent data monitoring committee concluded that the study would not meet its primary endpoint of improved overall survival. view more (2008-04-28)
New therapy found to prevent heart failure
A landmark study has successfully demonstrated a 29 percent reduction in heart failure or death in patients with heart disease who received an implanted cardiac resynchronization therapy device with defibrillator (CRT-D) versus patients who received only an implanted cardiac defibrillator (ICD-only). view more (2009-06-24)
Urgent Surgery Is Not Always Necessary To Treat Stroke Caused By Brain Haemorrhage
The results of a major international Medical Research Council (MRC) trial, undertaken in collaboration with the Stroke Association, show that early surgery is not always the best treatment for one of the commonest and most lethal forms of stroke. The results of the trial, published in this week's edition of The Lancet, will help doctors decide the... view more... (2005-01-27)
Scientists move towards stem cell therapy trials to mend shattered bones
The UK Stem Cell Foundation, the Medical Research Council and Scottish Enterprise, in partnership with the Chief Scientist's Office, are funding a £1.4 million project to further the research at the University of Edinburgh with a view to setting up a clinical trial within two years. view more (2008-02-19)
Gleevec decreases cancer recurrence for patients with primary gastrointestinal stromal tumor
Preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary gastrointestinal stromal tumor (GIST), a type of tumor usually found in the stomach or small intestine, showed that patients who received imatinib mesylate (Gleevec ®) after complete removal of their tumor were significantly less likely to... view more... (2007-04-13)
All placebos not created alike
The debate about the existence of a placebo effect has heated up over the past year as more and more lab experiments are detecting immediate physiological responses to placebos. view more (2006-02-01)
Clinical trial supports better treatment for lupus nephritis
Treating lupus patients suffering from kidney inflammation with a medicine known as mycophenolate mofetil may be more effective in inducing remission than treating them with the standard regimen of intravenous cyclophosphamide (Cytoxan), a new clinical trial indicates. view more (2005-11-28)
Vitamin B3 reduces Alzheimer's symptoms, lesions
An over-the-counter vitamin in high doses prevented memory loss in mice with Alzheimer's disease, and UC Irvine scientists now are conducting a clinical trial to determine its effect in humans. view more (2008-11-05)
Anemic children with cancer benefit from erythropoietin
Children with cancer who develop anemia during chemotherapy can benefit from a weekly dose of erythropoietin (EPO), according to researchers at St. Jude Children's Research Hospital. view more (2006-07-28)
First human trial of antibacterial contact lens
Biotechnology company Biosignal Ltd and the Institute for Eye Research have received ethics approval for the first human clinical trial of an antibacterial extended-wear contact lens. view more (2006-06-29)
Molecular signature may identify cisplatin-sensitive breast tumors
Researchers at the Massachusetts General Hospital (MGH) Cancer Center have identified a subgroup of hard-to-treat breast cancers that may be sensitive to the drug cisplatin, rarely used in the treatment of breast tumors. view more (2007-04-20)
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