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Clinical trial volunteers mostly indifferent -- but not blind to -- researchers' financial conflicts
Unless a researcher has stock ownership in a company whose drug is being tested, telling potential research volunteers about an investigator's financial interests is unlikely to affect their willingness to volunteer, a new study shows. view more (2008-04-07)
Diabetes drug shows promise against multiple sclerosis
A drug currently FDA-approved for use in diabetes shows some protective effects in the brains of patients with relapsing remitting multiple sclerosis. view more (2009-05-27)
MGH initiates phase I diabetes trial
Scientists at the Massachusetts General Hospital (MGH) have initiated a phase 1 clinical trial to reverse type 1 diabetes. view more (2008-03-14)
World-first swine-flu vaccine trial reveals one dose provides 'strong immune response'
Results from the first swine-flu vaccine trials taking place in Leicester reveal a strong immune response after just one dose. view more (2009-09-04)
Penn study identifies patients most at-risk for secondary strokes
Among patients who have suffered a single stroke, researchers at the University of Pennsylvania School of Medicine, along with colleagues at other institutions, have found that severe stenosis, or narrowing, of the arteries in the head represents a major risk factor for the development of a subsequent stroke. view more (2006-01-30)
Mayo Clinic tests novel vaccine to treat aggressive brain tumors
A vaccine that has significantly increased life expectancy in early tests of patients with glioblastoma multiforme (GBM) − the most common, most aggressive form of brain cancer in adults − is now being offered through a clinical trial at Mayo Clinic in Jacksonville. view more (2007-10-23)
Early disclosure: post-operative radiotherapy improves progression-free survival in prostate cancer
Immediate post-operative radiotherapy following surgery to remove the prostate results in improved progression-free survival for prostate cancer patients, according to the results of a study presented here today (Tuesday 26th October 2004) by Prof Michel Bolla of CHU de Grenoble, Grenoble, France, at the 23rd Meeting of the European Society for... view more... (2004-10-26)
Initial Results Show Pregnant Women Mount Strong Immune Response To One Dose of 2009 H1N1 Flu Vaccine
Healthy pregnant women mount a robust immune response following just one dose of 2009 H1N1 influenza vaccine, according to initial results from an ongoing clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. view more (2009-11-03)
High-flux hemodialysis prolongs survival in many patients with CKD
High-flux hemodialysis (which removes large toxins) reduces the risk of premature death in many patients with chronic kidney disease (CKD), according to a study appearing in the March 2009 issue of the Journal of the American Society Nephrology (JASN). view more (2009-02-23)
Retinoid cream associated with death in clinical trial, but relationship does not appear causal
Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result. view more (2009-01-20)
Sirolimus-eluting Coronary Stent is cost effective vs. bypass surgery
An independent analysis of a clinical trial comparing the cost-effectiveness of the CYPHER® Sirolimus-eluting Coronary Stent vs. bypass surgery suggests that treatment with the CYPHER® Stent offers a potential cost-savings over bypass surgery. view more (2005-10-21)
Success of new treatment halts international blood pressure drug trial
An international trial comparing blood-pressure lowering treatments has been stopped early due to the significantly better performance of one of the treatments in the trial. view more (2004-12-08)
Northwestern researchers launch Avastin trial for pancreatic tumors
Avastin is designed to inhibit Vascular Endothelial Growth Factor (VEGF), a protein that plays an important role in tumor angiogenesis or blood vessel formation, and maintenance of existing tumor vessels. view more (2006-02-22)
New therapy reduces mortality in patients with severe COPD
Patients with severe COPD may benefit more from therapy that combines salmeterol and fluticasone [SFC] than treatment with tiotropium, according to results from a long-term, multi-center study, "Investigating New Standards for Prophylaxis in Reducing Exacerbations" (INSPIRE) that directly compared the two therapies. view more (2007-12-28)
India continues to progress in AIDS vaccine development efforts
A second Phase I AIDS vaccine clinical trial in India was successfully completed, the Indian Council of Medical Research, the National AIDS Control Organization and the International AIDS Vaccine Initiative announced. The results of the trial of an MVA-based AIDS vaccine candidate (TBC-M4), which was conducted in Chennai, indicated that the... view more... (2008-08-18)
"EuroVacc 02" HIV Vaccine trial begins
The European Vaccine Effort against HIV/AIDS, today announced that a phase I clinical trial of novel investigational vaccines comprising DNA-HIV-C and NYVAC-HIV-C for the prevention of HIV infection has started in Lausanne and London in February 2005. These vaccines are based on HIV subtype C, which is prevalent in China, India and sub-Saharan... view more... (2005-02-16)
U of Minnesota study finds thalidomide shows promise for treatment of recurrent ovarian cancer
Thalidomide, a drug blamed in the 1950s for causing birth defects, is now showing promise as a safe and effective treatment for women with recurrent ovarian cancer, according to a study led by a University of Minnesota Cancer Center researcher. view more (2008-02-28)
Study supports possible role of urate in slowing Parkinson's disease progression
By examining data from a 20-year-old clinical trial, a research team based at the MassGeneral Institute for Neurodegenerative Diseases (MGH-MIND) and Harvard School of Public Health (HSPH), has found evidence supporting the findings of their 2008 study - that elevated levels of the antioxidant urate may slow the progression of Parkinson's disease. view more (2009-10-13)
Autism Consortium members publish in PNAS: Mechanism, treatment for Rett syndrome -- top cause autism girls
The Autism Consortium, an innovative research, clinical and family collaboration dedicated to radically accelerating research and enhancing clinical care for autism spectrum disorders (ASDs), announced today that several Consortium members published a paper with significance for clinical trials in autism in the Proceedings of the National Academy... view more... (2009-02-10)
Liverpool to trial new pancreatic cancer therapy
Patients in Liverpool are to trial a new therapy for pancreatic cancer - a disease which sees most sufferers die within a year of diagnosis. view more (2007-03-16)
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