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Early results from clinical trials of 2009 H1N1 influenza vaccines in healthy adults
We are encouraged by reports that are now emerging from various clinical trials of 2009 H1N1 influenza vaccines, conducted by various vaccine manufacturers. view more (2009-09-14)
Pain relieving effects of acupuncture are limited
The pain relieving effects of acupuncture compared with placebo are small and seem to lack clinical relevance, according to a study published on bmj.com today. view more (2009-01-28)
Research Ethics Committees identify and correct problems in applications to do cancer trials
Researchers running cancer trials are often critical of the Research Ethics Committee (REC) process they have to go through to get their trials approved, complaining that it's too complex, burdensome and sometimes unreasonable. In the UK only 17% of research study applications are given immediate favourable opinion by RECs. view more (2008-08-29)
Reanalysis of controversial meta-analysis says writing off rosiglitazone may be premature
Rosiglitazone, a drug marketed by GlaxoSmithKline as Avandia® for the treatment of type 2 diabetes, came under fire after an article published online May 21 by the New England Journal of Medicine linked it to significantly increased risk of heart attack and cardiovascular death. view more (2007-08-10)
Chemotherapy trial proves the worth of including elderly patients in clinical trials
Doctors should be encouraged to include many more elderly people in clinical trials than they do at present, Dr Olavo Feher told the 3rd European Breast Cancer Conference in Barcelona today (Wednesday 20 March). Dr Feher, attending physician at the Hospital do Cancer in Sao Paulo, Brazil, said that the elderly were under-represented in clinical... view more... (2002-03-18)
Inert gas may help stop damaged nerve cells from dying
Scientists from Imperial College London have discovered that xenon gas could help in protecting damaged nerve cells. The research, published today in Anesthesiology, shows that xenon, an inert gas, acts as a neuroprotectant, helping to protect damaged nerve cells from dying. Based upon pre-clinical trials, researchers believe it could have human... view more... (2002-05-29)
Munich Biotech reports additional positive data from MBT- 0206 Phase I trial
Continued Tolerability, Quality of Life Improvement, Stabilization and Regression Seen in Cancer Patients on Extension Past Phase I Clinical Trials Munich, March 25th, 2004 - Munich Biotech AG has announced details of results presented during a recent congress of clinical investigators, reporting on results of Phase I trials of MBT-0206 in cancer... view more... (2004-03-25)
Choosing healthy embryos in IVF
A revolutionary method for detecting which human embryos are most likely to develop successfully to the stage at which they implant in the womb has been developed by scientists at the University of York and clinicians at Leeds General Infirmary. The research has been funded by the Medical Research Council. The discovery, if confirmed in clinical... view more... (2002-05-07)
Key to treating killer disease may be uncovered by UK team
UK researchers think they are close to finding the first effective treatment to fight one of the biggest killer diseases in the UK. Professor Peter Barnes will present the work at the British Endocrine Societies 2005 meeting in Harrogate. view more (2005-04-01)
Ways to improve informed consent are testable, study says
New ways to make sure people are adequately informed about the risks and benefits of taking part in a clinical trial can be field-tested for effectiveness as vigorously as new medical treatments themselves, a study led by a Johns Hopkins bioethicist suggests. view more (2008-01-14)
How effective are opioids in chronic pain relief?
Fentanyl skin patches achieve better pain relief and an enhanced quality of life than sustained release oral morphine, say patients with chronic non-cancer pain in a study in this week's BMJ. Patients with chronic non-cancer pain, requiring continuous treatment with potent opioids, were randomly assigned to two groups to assess their treatment... view more... (2001-05-09)
Tumor response may not be best measure of efficacy in non-small cell lung cancer treatment
Researchers typically evaluate the effectiveness of a new cancer treatment by looking at how tumors respond to it. But in the case of advanced non-small cell lung cancer, there may be a better way to assess effectiveness. view more (2006-06-06)
National call for cancer clinical trial system to be more responsive to community needs
Addressing the nation's continuing poor performance in cancer clinical trial participation, particularly among racial and ethnic minorities and low income groups, will require meaningful public involvement in the design and implementation of clinical trials, according to a landmark report released today. view more (2008-11-11)
Further Evidence That Vitamin Supplements Do Not Protect Against Cardiovascular Disease (p 2017)
A meta-analysis of randomised trials in this week's issue of THE LANCET provides further evidence that antioxidant vitamins are not effective in reducing the risk of cardiovascular disease. Supplements containing vitamin A compounds could actually contribute to an increase in cardiovascular death and all-cause mortality. Some previous studies have... view more... (2003-06-11)
Researchers: Few heart disease trials reporting sex-specific results
Heart disease differences in men and women continue to be poorly understood because women are included in clinical trials far less than men, and even when women are included, study results are not reported by sex. view more (2007-01-31)
Many clinicians unaware of federally funded research on alternative therapies
Approximately one in four practicing clinicians appear to be aware of two major federally funded clinical trials of alternative therapies, and many do not express confidence in their ability to interpret research results. view more (2009-04-14)
Moores UCSD Cancer Center studying novel leukemia vaccine for high-risk patients
Researchers at the Moores Cancer Center at the University of California, San Diego (UCSD) are conducting clinical trials of a novel therapy aimed at revving up the immune system to combat a particularly difficult-to-treat form of leukemia. view more (2008-11-04)
Penn researchers find treatment for MS also reduces vision loss in MS patients
According to a study that appears in the April 17 issue of Neurology, researchers at the University of Pennsylvania School of Medicine have found that natalizumab (TYSABRI®) - a drug that slows disability and reduces relapse rates in patients with multiple sclerosis (MS) - also reduces vision loss in patients with relapsing MS. view more (2007-04-17)
Viagra for women? Drug developed as antidepressant effective in treating low libido
Pooled results from three separate clinical trials of flibanserin, a drug originally created as an antidepressant, show it is effective in treating women with acquired hypoactive sexual desire disorder. These trials were the first ever to test a therapy that works at the level of the brain to enhance libido in women reporting low sexual desire. view more (2009-11-16)
Only two per cent of child drug trials have independent safety checks
Only two per cent of paediatric drug trials reported using independent safety monitoring committees that can help lead to the early detection of adverse drug reactions, according to a major review published in the journal Acta Paediatrica. view more (2008-03-19)
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