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Folic acid supplementation does not appear to reduce risk of cardiovascular diseases
An analysis of previous studies suggests that for people with a history of vascular disease, folic acid supplementation does not decrease the risk of coronary heart disease or stroke, as has been suggested in some research. view more (2006-12-13)
World-first swine-flu vaccine trial reveals one dose provides 'strong immune response'
Results from the first swine-flu vaccine trials taking place in Leicester reveal a strong immune response after just one dose. view more (2009-09-04)
World-class formula for fighting disease
One of the most exciting developments in clinical research in decades is taking place at the University of Leeds, led by our professor of cancer medicine Peter Selby in collaboration with the Medical Research Council. The creation of a new network for world-class researchers in subjects such as medicines for children, Alzheimer's, diabetes, mental... view more... (2005-01-27)
Participants in antidepressant drug trials are atypical patients, UT Southwestern researchers report
One reason antidepressant medication treatments do not work as well in real life as they do in clinical studies could be the limited type of study participants selected, researchers at UT Southwestern Medical Center have found. view more (2009-05-13)
Analysis confirms benefits of combining trastuzumab and chemotherapy
A recent meta-analysis of five major breast cancer trials has confirmed that combination treatment with the antibody trastuzumab and chemotherapy improves survival in women with operable HER-2 positive breast cancer. view more (2007-07-09)
Oxford BioMedica Describes the Manufacturing Process for Prosavin at Bio2003
Oxford, UK: 23 June 2003. Oxford BioMedica announced today the details of its novel manufacturing process for ProSavin®, for the treatment of Parkinson's disease, that will be presented at the BIO 2003 Annual Convention in Washington DC on 25 June. The new manufacturing process has the capacity to satisfy all of the Company's requirements up... view more... (2003-06-23)
The Statin Wars: Why AstraZeneca Must Retreat (p 1341)
On Thursday 23 October, AstraZeneca, one of the world's largest pharmaceutical companies, will announce its third-quarter financial results. This coincides with a robust editorial in this week's issue of THE LANCET which calls into question AstraZeneca's high-profile marketing of rosuvastatin, a drug launched into the global statin market last... view more... (2003-10-22)
Future Pill for Premature Ejaculation a Success in Trials
A new tablet could hold the key for men who suffer premature ejaculation, reports Marina Murphy in Chemistry & Industry Magazine. Trials by a US company have shown the pill, compound LI 301, to have an effect on everyone tested. Trials suggest the drug starts working within two hours, so it could be taken on an as-needed basis. Currently,... view more... (2004-02-17)
Trial success for diabetic nerve therapy
A potentially ground-breaking treatment for nerve damage caused by diabetes has shown promising results in preclinical and early patient trials. view more (2006-05-31)
Vitamin E supplementation shows no overall benefit for major cardiovascular events or cancer
In an article in the July 6 JAMA, I-Min Lee, M.B.B.S., Sc.D., of Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues analyzed data from the vitamin E component of the Women's Health Study, which tested whether vitamin E supplementation decreases the risk of cardiovascular disease and cancer among healthy women. view more (2005-07-06)
Children's cancer group recommends global evaluation system for neuroblastoma to improve treatment
An international coalition of pediatric cancer physicians and researchers has developed new systems to standardize studies of neuroblastomas across the world. view more (2008-12-09)
New links in the cystic fibrosis chain uncover potential therapeutics
Cystic fibrosis (CF) is an inherited disease caused by mutations in the CFTR gene. Each mutation has number of effects on the cells of the lungs. view more (2007-10-19)
Keeping ideology and bureaucracy out of science (p 501)
The current debate surrounding the ethics and accountability of scientific research is discussed in this week's editorial, with concern that well-meaning monitoring processes implemented in the wake of scandals like alderhay in the UK may have 'the potential to delay, impede, or halt research'. A recent call for the investigation of NIH-funded... view more... (2004-02-11)
Combination drug therapy could substantially improve symptoms of rheumatoid arthritis (pp 670, 675)
The combination of two drugs - both partly effective for rheumatoid arthritis patients when given individually - could be an important development in substantially reducing symptoms and joint destruction for people with rheumatoid arthritis, conclude authors of a study in this week's issue of THE LANCET. Rheumatoid arthritis affects around 1% of... view more... (2004-02-25)
Drug-eluting stents found safe, superior to bare metal stents
Drug-eluting stents were safe and superior to bare metal stents in preventing death and heart attacks among 262,700 "real-world" patients enrolled in a nationwide registry of cardiovascular disease, according to researchers from Duke University Medical Center. view more (2009-03-30)
Want a reason to love your lower belly fat? It's rich in stem cells
Fat removed from the lower abdomen and inner thigh through liposuction was found to be an excellent source of stem cells, with higher stem cell concentrations than other areas of the body. view more (2008-07-24)
Prostate cancer research may be faster with PSA endpoints
A new study from Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia, who are members of the Southwest Oncology Group (SWOG), suggests that certain changes in prostate-specific antigen (PSA) levels may serve as surrogate endpoints for prostate cancer survival. view more (2006-04-19)
Open letter: Implementation of EU Directive on clinical trials
Dear Colleagues, As you are aware, the EU Directive 2001/20/EC implementing Good Clinical Practice into clinical trials is currently being translated into the national legislation of EU member states (and will also be adopted by future EU countries). The deadline for application is the May1, 2004. This Directive poses a number of important... view more... (2004-02-25)
Alzheimer's drug based on Purdue-designed inhibitor begins clinical trials
A drug based on the design of a Purdue University researcher to treat Alzheimer's disease began the first phase of human clinical trials this week. view more (2007-06-25)
Avoiding wishful thinking over new drugs - more trials should be double-blinded say cancer experts
Italian researchers have urged that doctors should, wherever possible, be 'blinded' to which drug a patient is receiving in a trial when the endpoint involves subjective judgements by the investigators. They believe it would lessen the risk of wishful thinking - an unconscious tendency by doctors to expect new drugs to perform better than the... view more... (2002-03-11)
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