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Animal studies show promise for development of human SARS immunisation (pp 2102, 2122, 2139)
An article and research letter in this week's issue of THE LANCET provide evidence for the effectiveness of experimental SARS immunisation in animal studies. Although further research is required, these preliminary results show the potential for the development of human SARS immunisation. Alexander Bukreyev from the US National Institutes of... view more... (2004-06-23)
SARS antiviral drug discovered: traditional antimalarial drug works against SARS coronavirus infection
Virologists from the Katholieke Universiteit Leuven (K.U.Leuven) in Belgium report that chloroquine, a widely used antimalarial drug, exhibits antiviral activity against the SARS coronavirus. Chloroquine is an inexpensive and safe drug available worldwide. SARS (Severe Acute Respiratory Syndrome) is a respiratory illness which was first... view more... (2004-09-03)
Study Implicates Human Coronavirus As Main Cause Of SARS
Early online publication: Tuesday 8 April 2003 FOR IMMEDIATE RELEASE Research from Hong Kong fast-tracked for publication on THE LANCET's website--www.thelancet.com--provides evidence that a new virus belonging to the family Coronaviridae is likely to be the main cause of Severe Acute Respiratory Syndrome (SARS). Malik Peiris from the University... view more... (2003-04-08)
An unexpected link between coronavirus replication and protein secretion in infected cells
Coronavirus replication is critically linked to two factors within the early secretory pathway, according to new findings by a team of Dutch researchers that are published June 13th in the open-access journal PLoS Pathogens. view more (2008-06-13)
New study finds no link between Kawasaki disease and newly discovered coronavirus
A newly described virus is not a cause of Kawasaki disease, according to an article by a group of researchers in Denver, Colorado. view more (2006-11-21)
A Different Antiviral For Treating SARS (p 2045)
A preliminary study published as a fast-track research letter in this week's issue of THE LANCET suggests that the antiviral agent glycyrrhizin could be more effective than other antivirals in the treatment of severe acute respiratory syndrome (SARS). Ribavirin is the most commonly used antiviral for treating SARS infection, used in combination... view more... (2003-06-11)
Researchers find 'secret weapon' used by SARS virus
In 2003, the highly contagious and often-deadly mystery disease now called SARS emerged explosively out of Southern China. It eventually killed an estimated 916 people in Asia, Europe, and North and South America-nearly one in ten of those it infected. view more (2006-08-08)
Details of the life cycle of SARS coronavirus
A team of scientists studying Severe Acute Respiratory Syndrome (SARS) has, for the first time, described how the SARS virus manufactures several of the materials required for making copies of itself. "It is essential, when you are looking for ways to stop a disease, that you know exactly how viruses make copies of themselves and... view more... (2003-07-08)
Novel Coronavirus Confirmed As Causative Agent Of SARS
Leading scientists worldwide investigating the cause of Severe Acute Respiratory Syndrome (SARS) confirm that a novel coronavirus is the primary cause of the disease. The study is published on THE LANCET's website (www.thelancet.com) at 0001 H Tuesday 22 July UK time. SARS was first reported in China in November 2002, with over 8300 cases and 812... view more... (2003-07-18)
Animal model shows early promise for SARS vaccine (p 1895)
Embargoed 0001 h (London time) 5 December 2003. US authors of a research letter in this week's issue of THE LANCET highlight preliminary findings which could mark an important step in the development of a human vaccine for severe acute respiratory syndrome (SARS). A genetically engineered vaccine was found to be effective in triggering an immune... view more... (2003-12-03)
SARS Reviewed (p 1730)
Authors from WHO describe the emergence of severe acute respiratory syndrome (SARS) in a Public Health article in this week's issue of THE LANCET. SARS is a new disease in human beings, first recognised in late February, 2003, in Hanoi, Vietnam. The severity of the disease, combined with its rapid spread along international air-travel routes,... view more... (2003-05-14)
Casting a wide net to fight coronaviruses
Coronaviruses-the family of viruses that causes the common cold-gained widespread recognition when the deadly severe acute respiratory syndrome, familiarly known as SARS, killed at least 800 people in 2003. view more (2005-09-06)
New Study Shows SARS Can Infect Brain Tissue
Severe acute respiratory syndrome (SARS), by its very name, indicates a disease of the respiratory tract. view more (2005-09-15)
Synthetic virus supports a bat origin for SARS
SARS - severe acute respiratory syndrome - alarmed the world five years ago as the first global pandemic of the 21st century. The coronavirus (SARS-CoV) that sickened more than 8,000 people - and killed nearly 800 of them - may have originated in bats, but the actual animal source is not known. view more (2008-11-26)
Update on SARS at FEMS Congress
Severe Acute Respiratory Syndrome represents only one of a series of new diseases caused by organisms grouped under the general title 'emerging pathogens'. Others will also be described and discussed at the 1st FEMS Congress of European Microbiologists at Ljubljana, Slovenia, June 29 - July 3, 2003. Several new haemorrhagic fever viruses will be... view more... (2003-06-24)
Variants Of SARS Virus Gives Clues To Origin Of Infection
A genetic study of the SARS virus fast-tracked for publication on THE LANCET's website-www.thelancet.com-gives an insight into the molecular behaviour of the novel coronavirus responsible for SARS. Comparison of a virus isolate from Singapore with isolates from other countries where SARS has struck suggests that there are main components of the... view more... (2003-05-08)
Penn researchers discover key to how SARS virus infects cells
Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. SARS is caused by an emergent coronavirus. view more (2005-08-02)
SARS without pneumonia could be common in outbreak areas (p 841)
Results of research from Hong Kong in this week's issue of THE LANCET suggests that severe acute respiratory syndrome (SARS) without pneumonia could be common among populations affected by SARS outbreaks. SARS has now affected 30 countries in five continents, with more than 8400 cases and more than 910 deaths. A novel virus, the... view more... (2004-03-10)
Enzyme inhibitors block replication Of SARS virus
Researchers have known since 2003 that a site on the virus is responsible for mediating proteases that allow the virus to replicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional cells in the body. view more (2006-03-28)
Discovery may help defang viruses
Researchers may be able to tinker with a single amino acid of an enzyme that helps viruses multiply to render them harmless, according to molecular biologists who say the discovery could pave the way for a fast and cheap method of making vaccines. view more (2007-08-29)
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